mGem: Sepsis and antimicrobial resistance in the context of advanced HIV disease
ABSTRACT Sepsis triggered by bloodstream infections (BSI) is a significant driver of HIV-related mortality, particularly among in-patients with advanced HIV disease (AHD). Currently, the incidence, etiology, and outcomes of BSI in this population are poorly defined. We review the existing evidence,...
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| Language: | English |
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American Society for Microbiology
2025-05-01
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| Series: | mBio |
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| Online Access: | https://journals.asm.org/doi/10.1128/mbio.00769-24 |
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| author | Rachel M. Wake Nelesh P. Govender |
| author_facet | Rachel M. Wake Nelesh P. Govender |
| author_sort | Rachel M. Wake |
| collection | DOAJ |
| description | ABSTRACT Sepsis triggered by bloodstream infections (BSI) is a significant driver of HIV-related mortality, particularly among in-patients with advanced HIV disease (AHD). Currently, the incidence, etiology, and outcomes of BSI in this population are poorly defined. We review the existing evidence, which shows an increased risk of BSI, particularly with antimicrobial-resistant (AMR) organisms, and higher BSI-associated mortality in patients with AHD. Causative bacterial and fungal pathogens are often unknown, but when identified, limited data show etiology has shifted probably owing to increasing coverage of antiretroviral treatment, antimicrobial prophylaxis, and rising global AMR trends. Further research is crucial to design and refine interventions before, during, and after hospital admission to reduce sepsis-related mortality in patients with AHD. |
| format | Article |
| id | doaj-art-22ff879a850d441bbffe8b41d5ff0e9a |
| institution | OA Journals |
| issn | 2150-7511 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj-art-22ff879a850d441bbffe8b41d5ff0e9a2025-08-20T02:24:54ZengAmerican Society for MicrobiologymBio2150-75112025-05-0116510.1128/mbio.00769-24mGem: Sepsis and antimicrobial resistance in the context of advanced HIV diseaseRachel M. Wake0Nelesh P. Govender1Wits Mycology Division, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, Gauteng, South AfricaWits Mycology Division, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, Gauteng, South AfricaABSTRACT Sepsis triggered by bloodstream infections (BSI) is a significant driver of HIV-related mortality, particularly among in-patients with advanced HIV disease (AHD). Currently, the incidence, etiology, and outcomes of BSI in this population are poorly defined. We review the existing evidence, which shows an increased risk of BSI, particularly with antimicrobial-resistant (AMR) organisms, and higher BSI-associated mortality in patients with AHD. Causative bacterial and fungal pathogens are often unknown, but when identified, limited data show etiology has shifted probably owing to increasing coverage of antiretroviral treatment, antimicrobial prophylaxis, and rising global AMR trends. Further research is crucial to design and refine interventions before, during, and after hospital admission to reduce sepsis-related mortality in patients with AHD.https://journals.asm.org/doi/10.1128/mbio.00769-24human immunodeficiency virusAIDSsepsisbloodstream infectionsantimicrobial resistance |
| spellingShingle | Rachel M. Wake Nelesh P. Govender mGem: Sepsis and antimicrobial resistance in the context of advanced HIV disease mBio human immunodeficiency virus AIDS sepsis bloodstream infections antimicrobial resistance |
| title | mGem: Sepsis and antimicrobial resistance in the context of advanced HIV disease |
| title_full | mGem: Sepsis and antimicrobial resistance in the context of advanced HIV disease |
| title_fullStr | mGem: Sepsis and antimicrobial resistance in the context of advanced HIV disease |
| title_full_unstemmed | mGem: Sepsis and antimicrobial resistance in the context of advanced HIV disease |
| title_short | mGem: Sepsis and antimicrobial resistance in the context of advanced HIV disease |
| title_sort | mgem sepsis and antimicrobial resistance in the context of advanced hiv disease |
| topic | human immunodeficiency virus AIDS sepsis bloodstream infections antimicrobial resistance |
| url | https://journals.asm.org/doi/10.1128/mbio.00769-24 |
| work_keys_str_mv | AT rachelmwake mgemsepsisandantimicrobialresistanceinthecontextofadvancedhivdisease AT neleshpgovender mgemsepsisandantimicrobialresistanceinthecontextofadvancedhivdisease |