Demographic profiles and risk factors for mortality in acute meningitis: A nationwide population‐based observational study
Abstract Aim Acute meningitis encompasses bacterial, viral (aseptic), fungal, tuberculous, and carcinomatous meningitis. The rate and risks of mortality in each type remain uncertain. This study aimed to elucidate these aspects in each type of meningitis. Methods This study utilized Japan's nat...
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| Format: | Article |
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Wiley
2024-01-01
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| Series: | Acute Medicine & Surgery |
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| Online Access: | https://doi.org/10.1002/ams2.920 |
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| author | Tetsuya Akaishi Kunio Tarasawa Kiyohide Fushimi Nobuo Yaegashi Masashi Aoki Kenji Fujimori |
| author_facet | Tetsuya Akaishi Kunio Tarasawa Kiyohide Fushimi Nobuo Yaegashi Masashi Aoki Kenji Fujimori |
| author_sort | Tetsuya Akaishi |
| collection | DOAJ |
| description | Abstract Aim Acute meningitis encompasses bacterial, viral (aseptic), fungal, tuberculous, and carcinomatous meningitis. The rate and risks of mortality in each type remain uncertain. This study aimed to elucidate these aspects in each type of meningitis. Methods This study utilized Japan's nationwide administrative Diagnosis Procedure Combination (DPC) database. Patients with acute meningitis, treated at 1132 DPC‐covered hospitals from 2016 to 2022, were enrolled. Results Among 47,366,222 cumulative hospitalized patients, 48,758 (0.10%) were hospitalized with acute meningitis. The types of meningitis were as follows: 10,338 with bacterial, 29,486 with viral/aseptic, 965 with fungal, 678 with tuberculous, and 3790 with carcinomatous meningitis. Bacterial and viral meningitis exhibited bimodal age distributions, with the first peak occurring at 0–9 years. The median onset age was below 50 years only in viral meningitis. The mortality rate was the highest in carcinomatous meningitis (39%), followed by fungal meningitis (21%), and the lowest in viral meningitis (0.61%). Mortality rates increased with age across all meningitis types, but this trend was less prominent in carcinomatous meningitis. The duration from admission to mortality was longer in fungal and tuberculous meningitis compared with other types. Staphylococcus aureus in bacterial meningitis (adjusted odds ratio 1.71; p = 0.0016) and herpes simplex virus in viral meningitis (adjusted odds ratio 1.53; p = 0.0467) exhibited elevated mortality rates. Conclusion Distinct demographic profiles and mortality rates were observed among different meningitis types. The high mortality rates in less common types of meningitis emphasize the necessity to further optimize the required diagnostic and treatment strategies. |
| format | Article |
| id | doaj-art-22fe8d5a4b264411937592ecdedab435 |
| institution | Kabale University |
| issn | 2052-8817 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Acute Medicine & Surgery |
| spelling | doaj-art-22fe8d5a4b264411937592ecdedab4352024-12-30T10:18:38ZengWileyAcute Medicine & Surgery2052-88172024-01-01111n/an/a10.1002/ams2.920Demographic profiles and risk factors for mortality in acute meningitis: A nationwide population‐based observational studyTetsuya Akaishi0Kunio Tarasawa1Kiyohide Fushimi2Nobuo Yaegashi3Masashi Aoki4Kenji Fujimori5Department of Neurology Tohoku University Graduate School of Medicine Sendai JapanDepartment of Health Administration and Policy Tohoku University Graduate School of Medicine Sendai JapanDepartment of Health Policy and Informatics Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Tokyo JapanDepartment of Obstetrics and Gynecology Tohoku University Graduate School of Medicine Sendai JapanDepartment of Neurology Tohoku University Graduate School of Medicine Sendai JapanDepartment of Health Administration and Policy Tohoku University Graduate School of Medicine Sendai JapanAbstract Aim Acute meningitis encompasses bacterial, viral (aseptic), fungal, tuberculous, and carcinomatous meningitis. The rate and risks of mortality in each type remain uncertain. This study aimed to elucidate these aspects in each type of meningitis. Methods This study utilized Japan's nationwide administrative Diagnosis Procedure Combination (DPC) database. Patients with acute meningitis, treated at 1132 DPC‐covered hospitals from 2016 to 2022, were enrolled. Results Among 47,366,222 cumulative hospitalized patients, 48,758 (0.10%) were hospitalized with acute meningitis. The types of meningitis were as follows: 10,338 with bacterial, 29,486 with viral/aseptic, 965 with fungal, 678 with tuberculous, and 3790 with carcinomatous meningitis. Bacterial and viral meningitis exhibited bimodal age distributions, with the first peak occurring at 0–9 years. The median onset age was below 50 years only in viral meningitis. The mortality rate was the highest in carcinomatous meningitis (39%), followed by fungal meningitis (21%), and the lowest in viral meningitis (0.61%). Mortality rates increased with age across all meningitis types, but this trend was less prominent in carcinomatous meningitis. The duration from admission to mortality was longer in fungal and tuberculous meningitis compared with other types. Staphylococcus aureus in bacterial meningitis (adjusted odds ratio 1.71; p = 0.0016) and herpes simplex virus in viral meningitis (adjusted odds ratio 1.53; p = 0.0467) exhibited elevated mortality rates. Conclusion Distinct demographic profiles and mortality rates were observed among different meningitis types. The high mortality rates in less common types of meningitis emphasize the necessity to further optimize the required diagnostic and treatment strategies.https://doi.org/10.1002/ams2.920carcinomatous meningitisdemographicsfungal meningitismortalitytuberculous meningitis |
| spellingShingle | Tetsuya Akaishi Kunio Tarasawa Kiyohide Fushimi Nobuo Yaegashi Masashi Aoki Kenji Fujimori Demographic profiles and risk factors for mortality in acute meningitis: A nationwide population‐based observational study Acute Medicine & Surgery carcinomatous meningitis demographics fungal meningitis mortality tuberculous meningitis |
| title | Demographic profiles and risk factors for mortality in acute meningitis: A nationwide population‐based observational study |
| title_full | Demographic profiles and risk factors for mortality in acute meningitis: A nationwide population‐based observational study |
| title_fullStr | Demographic profiles and risk factors for mortality in acute meningitis: A nationwide population‐based observational study |
| title_full_unstemmed | Demographic profiles and risk factors for mortality in acute meningitis: A nationwide population‐based observational study |
| title_short | Demographic profiles and risk factors for mortality in acute meningitis: A nationwide population‐based observational study |
| title_sort | demographic profiles and risk factors for mortality in acute meningitis a nationwide population based observational study |
| topic | carcinomatous meningitis demographics fungal meningitis mortality tuberculous meningitis |
| url | https://doi.org/10.1002/ams2.920 |
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