HiCLR: Knowledge-Induced Hierarchical Contrastive Learning with Retrosynthesis Prediction Yields a Reaction Foundation Model

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Main Authors: Jialu Wu, Yiheng Zhu, Xiaorui Wang, Yitong Li, Mingze Yin, Tianyue Wang, Yuqiang Han, Yu Kang, Yafeng Deng, Jian Wu, Chang-Yu Hsieh, Tingjun Hou
Format: Article
Language:English
Published: American Chemical Society 2025-06-01
Series:JACS Au
Online Access:https://doi.org/10.1021/jacsau.5c00289
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author Jialu Wu
Yiheng Zhu
Xiaorui Wang
Yitong Li
Mingze Yin
Tianyue Wang
Yuqiang Han
Yu Kang
Yafeng Deng
Jian Wu
Chang-Yu Hsieh
Tingjun Hou
author_facet Jialu Wu
Yiheng Zhu
Xiaorui Wang
Yitong Li
Mingze Yin
Tianyue Wang
Yuqiang Han
Yu Kang
Yafeng Deng
Jian Wu
Chang-Yu Hsieh
Tingjun Hou
author_sort Jialu Wu
collection DOAJ
format Article
id doaj-art-22fb3e646f2b486a97ac0694e39dc4ac
institution DOAJ
issn 2691-3704
language English
publishDate 2025-06-01
publisher American Chemical Society
record_format Article
series JACS Au
spelling doaj-art-22fb3e646f2b486a97ac0694e39dc4ac2025-08-20T03:09:00ZengAmerican Chemical SocietyJACS Au2691-37042025-06-01573140315510.1021/jacsau.5c00289HiCLR: Knowledge-Induced Hierarchical Contrastive Learning with Retrosynthesis Prediction Yields a Reaction Foundation ModelJialu Wu0Yiheng Zhu1Xiaorui Wang2Yitong Li3Mingze Yin4Tianyue Wang5Yuqiang Han6Yu Kang7Yafeng Deng8Jian Wu9Chang-Yu Hsieh10Tingjun Hou11College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, ChinaCollege of Computer Science and Technology, Zhejiang University, Hangzhou, Zhejiang, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao, ChinaCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, ChinaCollege of Computer Science and Technology, Zhejiang University, Hangzhou, Zhejiang, ChinaCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, ChinaCollege of Computer Science and Technology, Zhejiang University, Hangzhou, Zhejiang, ChinaCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, ChinaCarbonSilicon AI Technology Co., Ltd., Hangzhou, Zhejiang, ChinaSchool of Public Health, Zhejiang University, Hangzhou, Zhejiang, ChinaCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, ChinaCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, Chinahttps://doi.org/10.1021/jacsau.5c00289
spellingShingle Jialu Wu
Yiheng Zhu
Xiaorui Wang
Yitong Li
Mingze Yin
Tianyue Wang
Yuqiang Han
Yu Kang
Yafeng Deng
Jian Wu
Chang-Yu Hsieh
Tingjun Hou
HiCLR: Knowledge-Induced Hierarchical Contrastive Learning with Retrosynthesis Prediction Yields a Reaction Foundation Model
JACS Au
title HiCLR: Knowledge-Induced Hierarchical Contrastive Learning with Retrosynthesis Prediction Yields a Reaction Foundation Model
title_full HiCLR: Knowledge-Induced Hierarchical Contrastive Learning with Retrosynthesis Prediction Yields a Reaction Foundation Model
title_fullStr HiCLR: Knowledge-Induced Hierarchical Contrastive Learning with Retrosynthesis Prediction Yields a Reaction Foundation Model
title_full_unstemmed HiCLR: Knowledge-Induced Hierarchical Contrastive Learning with Retrosynthesis Prediction Yields a Reaction Foundation Model
title_short HiCLR: Knowledge-Induced Hierarchical Contrastive Learning with Retrosynthesis Prediction Yields a Reaction Foundation Model
title_sort hiclr knowledge induced hierarchical contrastive learning with retrosynthesis prediction yields a reaction foundation model
url https://doi.org/10.1021/jacsau.5c00289
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