Reconnoitering the role of Lipid Metabolites in Ferroptosis
Ferroptosis is a distinct form of regulated cell death driven by iron-dependent lipid peroxidation. It is different from other cell death forms like apoptosis, necrosis, and autophagy. Unlike apoptosis, ferroptosis is induced by the accumulation of reactive lipid peroxides and lacks the typical feat...
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Elsevier
2025-03-01
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| Series: | Advances in Redox Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667137924000249 |
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| author | Manikandan Vani Raju Meenakshi Kaniyur Chandrasekaran Rathi Muthaiyan Ahalliya Gopalakrishnan Velliyur Kanniappan |
| author_facet | Manikandan Vani Raju Meenakshi Kaniyur Chandrasekaran Rathi Muthaiyan Ahalliya Gopalakrishnan Velliyur Kanniappan |
| author_sort | Manikandan Vani Raju |
| collection | DOAJ |
| description | Ferroptosis is a distinct form of regulated cell death driven by iron-dependent lipid peroxidation. It is different from other cell death forms like apoptosis, necrosis, and autophagy. Unlike apoptosis, ferroptosis is induced by the accumulation of reactive lipid peroxides and lacks the typical features of cell lysis. Ferroptosis is regulated through mechanisms involving iron accumulation and lipid peroxidation, primarily driven by lipoxygenases. Glutathione Peroxidase 4 (GPX4) plays a critical role by mitigating lipid hydroperoxide accumulation. The incorporation of polyunsaturated fatty acids into cellular membranes, facilitated by enzymes such as ACSL4 and LPCAT3, enhances susceptibility to ferroptosis. Ferroptosis is implicated in various pathological conditions, including cancer, neurodegenerative diseases, and ischemic injuries. This review explores the potential of lipid metabolites as ferroptosis inducers for cancer therapy. By synthesizing recent findings on the interplay between ferroptosis and lipid metabolism, this study highlights new research directions and therapeutic strategies across diverse diseases. |
| format | Article |
| id | doaj-art-22fa1c51e3aa4f2a9c4e6672ce20b929 |
| institution | OA Journals |
| issn | 2667-1379 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advances in Redox Research |
| spelling | doaj-art-22fa1c51e3aa4f2a9c4e6672ce20b9292025-08-20T02:05:13ZengElsevierAdvances in Redox Research2667-13792025-03-011410011710.1016/j.arres.2024.100117Reconnoitering the role of Lipid Metabolites in FerroptosisManikandan Vani Raju0Meenakshi Kaniyur Chandrasekaran1Rathi Muthaiyan Ahalliya2Gopalakrishnan Velliyur Kanniappan3Department of Biochemistry, Karpagam Academy of Higher Education, Coimbatore 641021, Tamil Nadu, IndiaDepartment of Biochemistry, Karpagam Academy of Higher Education, Coimbatore 641021, Tamil Nadu, IndiaDepartment of Biochemistry, Karpagam Academy of Higher Education, Coimbatore 641021, Tamil Nadu, India; Corresponding author at: Department of Biochemistry, Karpagam Academy of Higher Education, Coimbatore, Tamilnadu 641 021, IndiaCentre for Global Health Research, Saveetha Medical College & Hospitals,Saveetha Institute of Medical and Technical Sciences (SIMATS) Chennai 602105, IndiaFerroptosis is a distinct form of regulated cell death driven by iron-dependent lipid peroxidation. It is different from other cell death forms like apoptosis, necrosis, and autophagy. Unlike apoptosis, ferroptosis is induced by the accumulation of reactive lipid peroxides and lacks the typical features of cell lysis. Ferroptosis is regulated through mechanisms involving iron accumulation and lipid peroxidation, primarily driven by lipoxygenases. Glutathione Peroxidase 4 (GPX4) plays a critical role by mitigating lipid hydroperoxide accumulation. The incorporation of polyunsaturated fatty acids into cellular membranes, facilitated by enzymes such as ACSL4 and LPCAT3, enhances susceptibility to ferroptosis. Ferroptosis is implicated in various pathological conditions, including cancer, neurodegenerative diseases, and ischemic injuries. This review explores the potential of lipid metabolites as ferroptosis inducers for cancer therapy. By synthesizing recent findings on the interplay between ferroptosis and lipid metabolism, this study highlights new research directions and therapeutic strategies across diverse diseases.http://www.sciencedirect.com/science/article/pii/S2667137924000249FerroptosisLipid metabolitesLipid peroxidationLipoxygenasesIron metabolismReactive oxygen Species |
| spellingShingle | Manikandan Vani Raju Meenakshi Kaniyur Chandrasekaran Rathi Muthaiyan Ahalliya Gopalakrishnan Velliyur Kanniappan Reconnoitering the role of Lipid Metabolites in Ferroptosis Advances in Redox Research Ferroptosis Lipid metabolites Lipid peroxidation Lipoxygenases Iron metabolism Reactive oxygen Species |
| title | Reconnoitering the role of Lipid Metabolites in Ferroptosis |
| title_full | Reconnoitering the role of Lipid Metabolites in Ferroptosis |
| title_fullStr | Reconnoitering the role of Lipid Metabolites in Ferroptosis |
| title_full_unstemmed | Reconnoitering the role of Lipid Metabolites in Ferroptosis |
| title_short | Reconnoitering the role of Lipid Metabolites in Ferroptosis |
| title_sort | reconnoitering the role of lipid metabolites in ferroptosis |
| topic | Ferroptosis Lipid metabolites Lipid peroxidation Lipoxygenases Iron metabolism Reactive oxygen Species |
| url | http://www.sciencedirect.com/science/article/pii/S2667137924000249 |
| work_keys_str_mv | AT manikandanvaniraju reconnoiteringtheroleoflipidmetabolitesinferroptosis AT meenakshikaniyurchandrasekaran reconnoiteringtheroleoflipidmetabolitesinferroptosis AT rathimuthaiyanahalliya reconnoiteringtheroleoflipidmetabolitesinferroptosis AT gopalakrishnanvelliyurkanniappan reconnoiteringtheroleoflipidmetabolitesinferroptosis |