Prophylaxis of Cytomegalovirus in Renal Transplant Recipients

The incidence and outcome of cytomegalovirus (CMV) infection and disease is compared in renal transplant recipients in relation lo the use of prophylaxis wiU1 high titre anti-CMV immunoglobulin. Seventy-three CMV-negative recipients (R-) who received kidneys from CMV-posilive donors (D+) were given...

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Main Authors: Allan S MacDonald, David L Nicol, Philip Belitsky, Spencer Lee
Format: Article
Language:English
Published: Wiley 1993-01-01
Series:Canadian Journal of Infectious Diseases
Online Access:http://dx.doi.org/10.1155/1993/916208
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author Allan S MacDonald
David L Nicol
Philip Belitsky
Spencer Lee
author_facet Allan S MacDonald
David L Nicol
Philip Belitsky
Spencer Lee
author_sort Allan S MacDonald
collection DOAJ
description The incidence and outcome of cytomegalovirus (CMV) infection and disease is compared in renal transplant recipients in relation lo the use of prophylaxis wiU1 high titre anti-CMV immunoglobulin. Seventy-three CMV-negative recipients (R-) who received kidneys from CMV-posilive donors (D+) were given prophylactic CMV hyperimmune globulin inlravenously al three-week intervals lo six monilis. They also received Lhree months of oral low dose acyclovir as did the remaining 288 patients who did nol receive hyperimmune globulin. There was a low incidence of CMV disease which did not differ between groups (D+R-, 10%: D+R+, 5 .5%, D- R+, 7%: D- R-, 0.8%). The major risk factor was the use of OKT3 to treat rejection. CMV disease was seen in 22% of this group (11 of 50) . compared with only 2% (seven of 311) of those not requiring OKT3. There was only one CMV-related death. but palients with CMV disease had a reduced graft survival rate (62% versus 90%). CMV hyperimmune globulin added lo acyclovir appears to reduce the incidence of CMV disease in high risk renal recipients (D+R-) in the lower risk groups.
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series Canadian Journal of Infectious Diseases
spelling doaj-art-22f6586b91014714b2b98a46da7a88402025-02-03T01:25:02ZengWileyCanadian Journal of Infectious Diseases1180-23321993-01-014Suppl C515710.1155/1993/916208Prophylaxis of Cytomegalovirus in Renal Transplant RecipientsAllan S MacDonaldDavid L NicolPhilip BelitskySpencer LeeThe incidence and outcome of cytomegalovirus (CMV) infection and disease is compared in renal transplant recipients in relation lo the use of prophylaxis wiU1 high titre anti-CMV immunoglobulin. Seventy-three CMV-negative recipients (R-) who received kidneys from CMV-posilive donors (D+) were given prophylactic CMV hyperimmune globulin inlravenously al three-week intervals lo six monilis. They also received Lhree months of oral low dose acyclovir as did the remaining 288 patients who did nol receive hyperimmune globulin. There was a low incidence of CMV disease which did not differ between groups (D+R-, 10%: D+R+, 5 .5%, D- R+, 7%: D- R-, 0.8%). The major risk factor was the use of OKT3 to treat rejection. CMV disease was seen in 22% of this group (11 of 50) . compared with only 2% (seven of 311) of those not requiring OKT3. There was only one CMV-related death. but palients with CMV disease had a reduced graft survival rate (62% versus 90%). CMV hyperimmune globulin added lo acyclovir appears to reduce the incidence of CMV disease in high risk renal recipients (D+R-) in the lower risk groups.http://dx.doi.org/10.1155/1993/916208
spellingShingle Allan S MacDonald
David L Nicol
Philip Belitsky
Spencer Lee
Prophylaxis of Cytomegalovirus in Renal Transplant Recipients
Canadian Journal of Infectious Diseases
title Prophylaxis of Cytomegalovirus in Renal Transplant Recipients
title_full Prophylaxis of Cytomegalovirus in Renal Transplant Recipients
title_fullStr Prophylaxis of Cytomegalovirus in Renal Transplant Recipients
title_full_unstemmed Prophylaxis of Cytomegalovirus in Renal Transplant Recipients
title_short Prophylaxis of Cytomegalovirus in Renal Transplant Recipients
title_sort prophylaxis of cytomegalovirus in renal transplant recipients
url http://dx.doi.org/10.1155/1993/916208
work_keys_str_mv AT allansmacdonald prophylaxisofcytomegalovirusinrenaltransplantrecipients
AT davidlnicol prophylaxisofcytomegalovirusinrenaltransplantrecipients
AT philipbelitsky prophylaxisofcytomegalovirusinrenaltransplantrecipients
AT spencerlee prophylaxisofcytomegalovirusinrenaltransplantrecipients