Hyperglycemic effect of n- methylglucamine antimonite (glucantime) in mice
N- methylglucamine antimonite (Glucantime) was injected intramuscularly to ten albino mice iri a dose of 15- 30 mg/kg for the first three days and then 60 mg/kg for twelve days. Glucantime was also injected in the same manner but in double doses to another teri mice. No drug was administred to ten m...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=899 |
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| Summary: | N- methylglucamine antimonite (Glucantime) was injected
intramuscularly to ten albino mice iri a dose of 15- 30 mg/kg for
the first three days and then 60 mg/kg for twelve days. Glucantime was
also injected in the same manner but in double doses to another teri mice.
No drug was administred to ten mice that were used as a control group.
In the sixteenth day, there were hyperglyce~ia, parenchymatous and
vacuolar degeneration, hepatocellular necrosis and inflammation in the
livers of the experimental mice which were marked asa double dose group.
The frequent monitoring of blood glucose of the patie:nts with Kala-azar
receiving Glucantime was suggested. |
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| ISSN: | 1309-6958 2146-1953 |