HER2 mutations in pulmonary adenocarcinoma presenting with ground-glass nodules
Abstract Background Human epidermal growth factor receptor 2 (HER2) mutations have been identified as oncogenic drivers and therapeutic targets in Non-small cell lung cancers (NSCLCs). The role of HER2 mutation in lung adenocarcinoma presented as sub-solid nodules (SSNs) have not been distinctly def...
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| Format: | Article |
| Language: | English |
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BMC
2025-07-01
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| Series: | World Journal of Surgical Oncology |
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| Online Access: | https://doi.org/10.1186/s12957-025-03955-3 |
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| author | Jiacheng Yin Shuhua Huo Zhencong Chen Yu Shi Qihai Sui Qun Wang Jiangjiang Xu Wei Jiang |
| author_facet | Jiacheng Yin Shuhua Huo Zhencong Chen Yu Shi Qihai Sui Qun Wang Jiangjiang Xu Wei Jiang |
| author_sort | Jiacheng Yin |
| collection | DOAJ |
| description | Abstract Background Human epidermal growth factor receptor 2 (HER2) mutations have been identified as oncogenic drivers and therapeutic targets in Non-small cell lung cancers (NSCLCs). The role of HER2 mutation in lung adenocarcinoma presented as sub-solid nodules (SSNs) have not been distinctly defined. This study comprehensively investigated the clinicopathological characteristics of HER2 mutation in patients with pulmonary SSNs. Methods In total, 717 patients with completely resected NSCLCs presented as SSNs were examined for HER2 mutation from January 2016 to December 2018. Age, sex, smoking history, radiologic features, operative procedure, pleural invasion, histologic subtypes and tumor-node-metastasis stage were collected. Kaplan-Meier method was used to estimate DFS, Log-rank test was used to compare the survival data. Logistic regression model was used to identify the predictors for HER2 mutation and the predictive nomogram was built. Results In this study, 47(6.6%) SSNs carried HER2 mutations. HER2 mutations were more frequent in subjects with younger age (P < 0.001) and smaller tumor size (P < 0.001), and were prone to occur in AIS and MIA (P < 0.001). The 5- year DFS rates for HER2 mutation and HER2 wild-type groups were similar (P = 0.509). According to the logistic regression analysis, age and maximum tumor size were independent variables correlated with HER2 mutation. A predictive nomogram model was constructed with a concordance statistic of 0.79 (0.71–0.87). Conclusions HER2 mutation was not uncommon in pulmonary SSNs. Younger age and smaller tumor size were associated with increased odds of HER2 mutation. Graphical abstract |
| format | Article |
| id | doaj-art-22ee72b187b84cc6937e2c0339400d34 |
| institution | DOAJ |
| issn | 1477-7819 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj-art-22ee72b187b84cc6937e2c0339400d342025-08-20T03:05:21ZengBMCWorld Journal of Surgical Oncology1477-78192025-07-012311910.1186/s12957-025-03955-3HER2 mutations in pulmonary adenocarcinoma presenting with ground-glass nodulesJiacheng Yin0Shuhua Huo1Zhencong Chen2Yu Shi3Qihai Sui4Qun Wang5Jiangjiang Xu6Wei Jiang7Department of Thoracic Surgery, Zhongshan Hospital of Fudan UniversityDepartment of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical UniversityDepartment of Thoracic Surgery, Zhongshan Hospital of Fudan UniversityDepartment of Thoracic Surgery, Zhongshan Hospital of Fudan UniversityDepartment of Thoracic Surgery, Zhongshan Hospital of Fudan UniversityDepartment of Thoracic Surgery, Zhongshan Hospital of Fudan UniversityDepartment of Thoracic Surgery, Fuding Hospital, Fujian University of Traditional Chinese MedicineDepartment of Thoracic Surgery, Zhongshan Hospital of Fudan UniversityAbstract Background Human epidermal growth factor receptor 2 (HER2) mutations have been identified as oncogenic drivers and therapeutic targets in Non-small cell lung cancers (NSCLCs). The role of HER2 mutation in lung adenocarcinoma presented as sub-solid nodules (SSNs) have not been distinctly defined. This study comprehensively investigated the clinicopathological characteristics of HER2 mutation in patients with pulmonary SSNs. Methods In total, 717 patients with completely resected NSCLCs presented as SSNs were examined for HER2 mutation from January 2016 to December 2018. Age, sex, smoking history, radiologic features, operative procedure, pleural invasion, histologic subtypes and tumor-node-metastasis stage were collected. Kaplan-Meier method was used to estimate DFS, Log-rank test was used to compare the survival data. Logistic regression model was used to identify the predictors for HER2 mutation and the predictive nomogram was built. Results In this study, 47(6.6%) SSNs carried HER2 mutations. HER2 mutations were more frequent in subjects with younger age (P < 0.001) and smaller tumor size (P < 0.001), and were prone to occur in AIS and MIA (P < 0.001). The 5- year DFS rates for HER2 mutation and HER2 wild-type groups were similar (P = 0.509). According to the logistic regression analysis, age and maximum tumor size were independent variables correlated with HER2 mutation. A predictive nomogram model was constructed with a concordance statistic of 0.79 (0.71–0.87). Conclusions HER2 mutation was not uncommon in pulmonary SSNs. Younger age and smaller tumor size were associated with increased odds of HER2 mutation. Graphical abstracthttps://doi.org/10.1186/s12957-025-03955-3HER2 mutationLung cancerSub-solid nodule |
| spellingShingle | Jiacheng Yin Shuhua Huo Zhencong Chen Yu Shi Qihai Sui Qun Wang Jiangjiang Xu Wei Jiang HER2 mutations in pulmonary adenocarcinoma presenting with ground-glass nodules World Journal of Surgical Oncology HER2 mutation Lung cancer Sub-solid nodule |
| title | HER2 mutations in pulmonary adenocarcinoma presenting with ground-glass nodules |
| title_full | HER2 mutations in pulmonary adenocarcinoma presenting with ground-glass nodules |
| title_fullStr | HER2 mutations in pulmonary adenocarcinoma presenting with ground-glass nodules |
| title_full_unstemmed | HER2 mutations in pulmonary adenocarcinoma presenting with ground-glass nodules |
| title_short | HER2 mutations in pulmonary adenocarcinoma presenting with ground-glass nodules |
| title_sort | her2 mutations in pulmonary adenocarcinoma presenting with ground glass nodules |
| topic | HER2 mutation Lung cancer Sub-solid nodule |
| url | https://doi.org/10.1186/s12957-025-03955-3 |
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