IL-31 and IL-8 in Cutaneous T-Cell Lymphoma: Looking for Their Role in Itch
The itch associated with cutaneous T-cell lymphoma (CTCL), including Mycosis Fungoides (MF) and Sézary syndrome (SS), is often severe and poorly responsive to treatment with antihistamines. Recent studies have highlighted the possible role of interleukins in nonhistaminergic itch. We investigated th...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2021/5582581 |
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| author | Maria Abreu Marta Miranda Mafalda Castro Iolanda Fernandes Renata Cabral Ana Helena Santos Sónia Fonseca João Rodrigues Magdalena Leander Catarina Lau Inês Freitas Susana Coimbra Alice Santos-Silva Margarida Lima |
| author_facet | Maria Abreu Marta Miranda Mafalda Castro Iolanda Fernandes Renata Cabral Ana Helena Santos Sónia Fonseca João Rodrigues Magdalena Leander Catarina Lau Inês Freitas Susana Coimbra Alice Santos-Silva Margarida Lima |
| author_sort | Maria Abreu |
| collection | DOAJ |
| description | The itch associated with cutaneous T-cell lymphoma (CTCL), including Mycosis Fungoides (MF) and Sézary syndrome (SS), is often severe and poorly responsive to treatment with antihistamines. Recent studies have highlighted the possible role of interleukins in nonhistaminergic itch. We investigated the role of IL-31 and IL-8 in CTCL, concerning disease severity and associated itch. Serum samples of 27 patients with CTCL (17 MF and 10 SS) and 29 controls (blood donors) were analyzed for interleukin- (IL-) 31 and IL-8; correlations with disease and itch severity were evaluated. IL-31 serum levels were higher in CTCL patients than in controls and higher in SS than in MF. Also, serum IL-31 levels were higher in patients with advanced disease compared to those with early disease, and they correlated positively with lactate dehydrogenase and beta 2-microglobulin levels, as well as with the Sézary cell count. Itch affected 67% of CTCL patients (MF: 47%; SS: 100%). Serum IL-31 levels were higher in itching patients than in controls and in patients without itching. There was no association between serum IL-8 and disease severity, nor with itching. Serum IL-8 levels correlated positively with peripheral blood leukocyte and neutrophil counts in CTCL patients. Our study suggests a role for IL-31 in CTCL-associated itch, especially in advanced disease and SS, offering a rational target for new therapeutic approaches. Increased serum IL-8 observed in some patients may be related to concomitant infections, and its role in exacerbating itch by recruiting neutrophils and promoting the release of neutrophil proteases deserves further investigation. |
| format | Article |
| id | doaj-art-22e6a02009734d449af015cce94075c5 |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-22e6a02009734d449af015cce94075c52025-02-03T01:24:51ZengWileyAdvances in Hematology1687-91041687-91122021-01-01202110.1155/2021/55825815582581IL-31 and IL-8 in Cutaneous T-Cell Lymphoma: Looking for Their Role in ItchMaria Abreu0Marta Miranda1Mafalda Castro2Iolanda Fernandes3Renata Cabral4Ana Helena Santos5Sónia Fonseca6João Rodrigues7Magdalena Leander8Catarina Lau9Inês Freitas10Susana Coimbra11Alice Santos-Silva12Margarida Lima13Centro Hospitalar Universitário do Porto (CHUP), Porto, PortugalFaculdade de Farmácia, Universidade do Porto (FFUP), Porto, PortugalServiço de Hematologia Clínica, Centro Hospitalar Universitário do Porto (CHUP), Porto, PortugalCentro Hospitalar Universitário do Porto (CHUP), Porto, PortugalCentro Hospitalar Universitário do Porto (CHUP), Porto, PortugalCentro Hospitalar Universitário do Porto (CHUP), Porto, PortugalCentro Hospitalar Universitário do Porto (CHUP), Porto, PortugalCentro Hospitalar Universitário do Porto (CHUP), Porto, PortugalCentro Hospitalar Universitário do Porto (CHUP), Porto, PortugalCentro Hospitalar Universitário do Porto (CHUP), Porto, PortugalCentro Hospitalar Universitário do Porto (CHUP), Porto, PortugalCooperativa de Ensino Superior Politécnico e Universitário (CESPU), Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde (IINFACTS), Gandra, Paredes, PortugalFaculdade de Farmácia, Universidade do Porto (FFUP), Porto, PortugalCentro Hospitalar Universitário do Porto (CHUP), Porto, PortugalThe itch associated with cutaneous T-cell lymphoma (CTCL), including Mycosis Fungoides (MF) and Sézary syndrome (SS), is often severe and poorly responsive to treatment with antihistamines. Recent studies have highlighted the possible role of interleukins in nonhistaminergic itch. We investigated the role of IL-31 and IL-8 in CTCL, concerning disease severity and associated itch. Serum samples of 27 patients with CTCL (17 MF and 10 SS) and 29 controls (blood donors) were analyzed for interleukin- (IL-) 31 and IL-8; correlations with disease and itch severity were evaluated. IL-31 serum levels were higher in CTCL patients than in controls and higher in SS than in MF. Also, serum IL-31 levels were higher in patients with advanced disease compared to those with early disease, and they correlated positively with lactate dehydrogenase and beta 2-microglobulin levels, as well as with the Sézary cell count. Itch affected 67% of CTCL patients (MF: 47%; SS: 100%). Serum IL-31 levels were higher in itching patients than in controls and in patients without itching. There was no association between serum IL-8 and disease severity, nor with itching. Serum IL-8 levels correlated positively with peripheral blood leukocyte and neutrophil counts in CTCL patients. Our study suggests a role for IL-31 in CTCL-associated itch, especially in advanced disease and SS, offering a rational target for new therapeutic approaches. Increased serum IL-8 observed in some patients may be related to concomitant infections, and its role in exacerbating itch by recruiting neutrophils and promoting the release of neutrophil proteases deserves further investigation.http://dx.doi.org/10.1155/2021/5582581 |
| spellingShingle | Maria Abreu Marta Miranda Mafalda Castro Iolanda Fernandes Renata Cabral Ana Helena Santos Sónia Fonseca João Rodrigues Magdalena Leander Catarina Lau Inês Freitas Susana Coimbra Alice Santos-Silva Margarida Lima IL-31 and IL-8 in Cutaneous T-Cell Lymphoma: Looking for Their Role in Itch Advances in Hematology |
| title | IL-31 and IL-8 in Cutaneous T-Cell Lymphoma: Looking for Their Role in Itch |
| title_full | IL-31 and IL-8 in Cutaneous T-Cell Lymphoma: Looking for Their Role in Itch |
| title_fullStr | IL-31 and IL-8 in Cutaneous T-Cell Lymphoma: Looking for Their Role in Itch |
| title_full_unstemmed | IL-31 and IL-8 in Cutaneous T-Cell Lymphoma: Looking for Their Role in Itch |
| title_short | IL-31 and IL-8 in Cutaneous T-Cell Lymphoma: Looking for Their Role in Itch |
| title_sort | il 31 and il 8 in cutaneous t cell lymphoma looking for their role in itch |
| url | http://dx.doi.org/10.1155/2021/5582581 |
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