Neferine alleviates intervertebral disc degeneration through KEAP1/NRF2/GPX4 and NF-κB signaling pathways

Neferine alleviates intervertebral disc degeneration through KEAP1/NRF2/GPX4 and NF-κB signaling pathways

Objective·To investigate the therapeutic effects of neferine (Nef) on intervertebral disc degeneration (IDD) and the underlying regulatory pathways.Methods·The effects of Nef on the viability and proliferation of nucleus pulposus cells were assessed using the cell counting kit-8 (CCK-8) assay. Molec...

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Bibliographic Details
Main Authors: WAN Hongjin, HU Yibin, WANG Xin, ZHANG Kai, QIN An, MA Peixiang, MA Hui, ZHAO Jie
Format: Article
Language:zho
Published: Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science) 2025-03-01
Series:Shanghai Jiaotong Daxue xuebao. Yixue ban
Subjects:
neferine
intervertebral disc degeneration
keap1/nrf2 signaling pathway
ferroptosis
nf-κb signaling pathway
inflammation
Online Access:https://xuebao.shsmu.edu.cn/CN/10.3969/j.issn.1674-8115.2025.03.002
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