Field evaluation of the Bioline Malaria Ag P.f/Pan rapid diagnostic test: causes of microscopy discordance and performance in Uganda

Field evaluation of the Bioline Malaria Ag P.f/Pan rapid diagnostic test: causes of microscopy discordance and performance in Uganda

Abstract Background Histidine Rich Protein 2 (HRP2)/pan-Lactate Dehydrogenase (pLDH) combination rapid diagnostic tests (RDTs) may address the shortcomings of RDTs that detect HRP2 alone. However, the relative contribution of the possible causes of discordant results (RDT-negative and microscopy-pos...

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Main Authors: Kisakye Diana Kabbale, Bienvenu Nsengimaana, Francis D. Semakuba, Brian A. Kagurusi, Caroline Mwubaha, Innocent Wiringilimaana, Thomas Katairo, Shahiid Kiyaga, Monica Mbabazi, Samuel Gonahasa, Moses R. Kamya, Stephen Tukwasibwe, Sam L. Nsobya, Victor Asua, Daudi Jjingo, Bosco Agaba, Catherine Maiteki-Sebuguzi, Jimmy Opigo, Kylie Hilton, Sarah G. Staedke, Grant Dorsey, Melissa D. Conrad, Bryan Greenhouse, Isaac Ssewanyana, Jessica Briggs
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Malaria Journal
Subjects:
Malaria
Plasmodium falciparum
HRP2/pLDH combination rapid diagnostic test
Performance
Specificity
Sensitivity
Online Access:https://doi.org/10.1186/s12936-025-05379-6
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