Advancements in Clinical Utilization of Recombinant Human Collagen: An Extensive Review
Introduction: Recombinant human collagen, developed through advanced recombinant DNA technology, has emerged as a cutting-edge biomaterial with diverse applications in medicine. It addresses significant limitations of animal-derived collagens, such as immunogenicity and the risk of zoonotic diseases...
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MDPI AG
2025-04-01
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| author | Isaac Wong Kai Jie Kar Wai Alvin Lee Song Eun Yoon Jong Keun Song Lisa Kwin Wah Chan Cheuk Hung Lee Eunji Jeong Jin-Hyun Kim Kyu-Ho Yi |
| author_facet | Isaac Wong Kai Jie Kar Wai Alvin Lee Song Eun Yoon Jong Keun Song Lisa Kwin Wah Chan Cheuk Hung Lee Eunji Jeong Jin-Hyun Kim Kyu-Ho Yi |
| author_sort | Isaac Wong Kai Jie |
| collection | DOAJ |
| description | Introduction: Recombinant human collagen, developed through advanced recombinant DNA technology, has emerged as a cutting-edge biomaterial with diverse applications in medicine. It addresses significant limitations of animal-derived collagens, such as immunogenicity and the risk of zoonotic diseases. Objective: This review evaluates the clinical applications, benefits, and challenges associated with recombinant human collagen, focusing on its potential to transform medical and surgical practices. Methods: A comprehensive search was conducted in MEDLINE, PubMed, and Ovid databases using keywords such as “Recombinant Human Collagen”, “Collagen-Based Biomaterials”, “Clinical Applications”, “Tissue Repair”, and “Wound Healing”. Relevant studies, including clinical trials and diagnostic applications, were analyzed and classified according to the Oxford Centre for Evidence-Based Medicine evidence hierarchy. Findings: Recombinant human collagen demonstrates superior mechanical properties and controlled degradation rates compared to traditional collagen sources. Clinical studies highlight its effectiveness in accelerating wound closure, promoting dermal regeneration, and minimizing scarring, making it particularly valuable in chronic wound management and surgical interventions. In tissue engineering, recombinant human collagen scaffolds have shown potential for regenerating cartilage, bone, and cardiovascular tissues by supporting cell proliferation, differentiation, and matrix deposition. Additionally, its adaptability for forming hydrogels and matrices enhances its suitability for drug delivery systems, enabling controlled and sustained release of therapeutic agents. Conclusion: Recombinant human collagen represents a transformative advancement in clinical practice, providing a safer and more effective alternative to traditional collagen sources. Its demonstrated success in wound healing, tissue engineering, and drug delivery highlights its potential to significantly improve patient outcomes. However, challenges such as high production costs, regulatory complexities, and long-term biocompatibility remain barriers to widespread clinical adoption. Further research and collaboration between biotechnology developers and regulatory authorities are essential to fully realize its clinical potential. |
| format | Article |
| id | doaj-art-22d857c8462b44eb9e331c92efaa1eeb |
| institution | DOAJ |
| issn | 2075-1729 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj-art-22d857c8462b44eb9e331c92efaa1eeb2025-08-20T03:13:45ZengMDPI AGLife2075-17292025-04-0115458210.3390/life15040582Advancements in Clinical Utilization of Recombinant Human Collagen: An Extensive ReviewIsaac Wong Kai Jie0Kar Wai Alvin Lee1Song Eun Yoon2Jong Keun Song3Lisa Kwin Wah Chan4Cheuk Hung Lee5Eunji Jeong6Jin-Hyun Kim7Kyu-Ho Yi8The Artisan Clinic, 435 Orchard Road, #20-03, Singapore 238877, SingaporeEverKeen Medical Centre, Hong KongBrandnew Aesthetic Surgery Clinic, Seoul, Republic of KoreaPixelab Plastic Surgery Clinic, Seoul, Republic of KoreaEverKeen Medical Centre, Hong KongEverKeen Medical Centre, Hong KongCollege of Medicine, Central Michigan University, Saginaw, MI, USAYou & I Clinic, Seoul, Republic of KoreaYou & I Clinic, Seoul, Republic of KoreaIntroduction: Recombinant human collagen, developed through advanced recombinant DNA technology, has emerged as a cutting-edge biomaterial with diverse applications in medicine. It addresses significant limitations of animal-derived collagens, such as immunogenicity and the risk of zoonotic diseases. Objective: This review evaluates the clinical applications, benefits, and challenges associated with recombinant human collagen, focusing on its potential to transform medical and surgical practices. Methods: A comprehensive search was conducted in MEDLINE, PubMed, and Ovid databases using keywords such as “Recombinant Human Collagen”, “Collagen-Based Biomaterials”, “Clinical Applications”, “Tissue Repair”, and “Wound Healing”. Relevant studies, including clinical trials and diagnostic applications, were analyzed and classified according to the Oxford Centre for Evidence-Based Medicine evidence hierarchy. Findings: Recombinant human collagen demonstrates superior mechanical properties and controlled degradation rates compared to traditional collagen sources. Clinical studies highlight its effectiveness in accelerating wound closure, promoting dermal regeneration, and minimizing scarring, making it particularly valuable in chronic wound management and surgical interventions. In tissue engineering, recombinant human collagen scaffolds have shown potential for regenerating cartilage, bone, and cardiovascular tissues by supporting cell proliferation, differentiation, and matrix deposition. Additionally, its adaptability for forming hydrogels and matrices enhances its suitability for drug delivery systems, enabling controlled and sustained release of therapeutic agents. Conclusion: Recombinant human collagen represents a transformative advancement in clinical practice, providing a safer and more effective alternative to traditional collagen sources. Its demonstrated success in wound healing, tissue engineering, and drug delivery highlights its potential to significantly improve patient outcomes. However, challenges such as high production costs, regulatory complexities, and long-term biocompatibility remain barriers to widespread clinical adoption. Further research and collaboration between biotechnology developers and regulatory authorities are essential to fully realize its clinical potential.https://www.mdpi.com/2075-1729/15/4/582recombinant human collagentissue engineeringwound healing |
| spellingShingle | Isaac Wong Kai Jie Kar Wai Alvin Lee Song Eun Yoon Jong Keun Song Lisa Kwin Wah Chan Cheuk Hung Lee Eunji Jeong Jin-Hyun Kim Kyu-Ho Yi Advancements in Clinical Utilization of Recombinant Human Collagen: An Extensive Review Life recombinant human collagen tissue engineering wound healing |
| title | Advancements in Clinical Utilization of Recombinant Human Collagen: An Extensive Review |
| title_full | Advancements in Clinical Utilization of Recombinant Human Collagen: An Extensive Review |
| title_fullStr | Advancements in Clinical Utilization of Recombinant Human Collagen: An Extensive Review |
| title_full_unstemmed | Advancements in Clinical Utilization of Recombinant Human Collagen: An Extensive Review |
| title_short | Advancements in Clinical Utilization of Recombinant Human Collagen: An Extensive Review |
| title_sort | advancements in clinical utilization of recombinant human collagen an extensive review |
| topic | recombinant human collagen tissue engineering wound healing |
| url | https://www.mdpi.com/2075-1729/15/4/582 |
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