Advances in theta-burst transcranial magnetic stimulation for auditory comprehension deficits in post-stroke aphasia

Aphasia is a language network disorder caused by organic brain lesions, which severely affects patients' daily communication and interaction. The therapeutic effect of conventional rehabilitation training alone is limited. Currently, Theta Burst Stimulation (TBS) is a novel therapeutic modality...

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Main Authors: Yuling Jing, Haoyang Duan, Wendong Yang, Hong Zhang, Lianxi Dong, Zhenlan Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Neurology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2025.1610016/full
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author Yuling Jing
Haoyang Duan
Wendong Yang
Hong Zhang
Lianxi Dong
Zhenlan Li
author_facet Yuling Jing
Haoyang Duan
Wendong Yang
Hong Zhang
Lianxi Dong
Zhenlan Li
author_sort Yuling Jing
collection DOAJ
description Aphasia is a language network disorder caused by organic brain lesions, which severely affects patients' daily communication and interaction. The therapeutic effect of conventional rehabilitation training alone is limited. Currently, Theta Burst Stimulation (TBS) is a novel therapeutic modality of repetitive Transcranial Magnetic Stimulation (rTMS) and is a commonly used patterned rTMS. It appears in the form of burst waves and mimics the natural firing pattern of hippocampal neurons under Theta rhythm. Based on rTMS, TBS embeds a pattern in which three 50 Hz pulse bursts are inserted into a 5 Hz pulse train. This stimulation pattern can induce cortical plasticity in a shorter period of time and is gradually being applied in the treatment of aphasia. Auditory comprehension, as the initial component of language input, involves the reception and storage of linguistic signals, as well as the analysis and integration of lexical semantics. The recovery of this ability plays a prerequisite role in the functional improvement of patients with post-stroke aphasia (PSA). In recent years, research on aphasia has mainly focused on speaking, reading, and writing abilities, with relatively less attention paid to auditory comprehension. Therefore, this article reviews the research progress related to the use of TBS in treating auditory comprehension in aphasia, aiming to provide new ideas and references for the clinical selection of TBS stimulation protocols.
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issn 1664-2295
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publisher Frontiers Media S.A.
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series Frontiers in Neurology
spelling doaj-art-22c92a97c82344c5a1ae375ee428515a2025-08-20T02:46:20ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-07-011610.3389/fneur.2025.16100161610016Advances in theta-burst transcranial magnetic stimulation for auditory comprehension deficits in post-stroke aphasiaYuling JingHaoyang DuanWendong YangHong ZhangLianxi DongZhenlan LiAphasia is a language network disorder caused by organic brain lesions, which severely affects patients' daily communication and interaction. The therapeutic effect of conventional rehabilitation training alone is limited. Currently, Theta Burst Stimulation (TBS) is a novel therapeutic modality of repetitive Transcranial Magnetic Stimulation (rTMS) and is a commonly used patterned rTMS. It appears in the form of burst waves and mimics the natural firing pattern of hippocampal neurons under Theta rhythm. Based on rTMS, TBS embeds a pattern in which three 50 Hz pulse bursts are inserted into a 5 Hz pulse train. This stimulation pattern can induce cortical plasticity in a shorter period of time and is gradually being applied in the treatment of aphasia. Auditory comprehension, as the initial component of language input, involves the reception and storage of linguistic signals, as well as the analysis and integration of lexical semantics. The recovery of this ability plays a prerequisite role in the functional improvement of patients with post-stroke aphasia (PSA). In recent years, research on aphasia has mainly focused on speaking, reading, and writing abilities, with relatively less attention paid to auditory comprehension. Therefore, this article reviews the research progress related to the use of TBS in treating auditory comprehension in aphasia, aiming to provide new ideas and references for the clinical selection of TBS stimulation protocols.https://www.frontiersin.org/articles/10.3389/fneur.2025.1610016/fullpost-stroke aphasiatranscranial magnetic stimulationauditory comprehensiontheta burst stimulationstroke
spellingShingle Yuling Jing
Haoyang Duan
Wendong Yang
Hong Zhang
Lianxi Dong
Zhenlan Li
Advances in theta-burst transcranial magnetic stimulation for auditory comprehension deficits in post-stroke aphasia
Frontiers in Neurology
post-stroke aphasia
transcranial magnetic stimulation
auditory comprehension
theta burst stimulation
stroke
title Advances in theta-burst transcranial magnetic stimulation for auditory comprehension deficits in post-stroke aphasia
title_full Advances in theta-burst transcranial magnetic stimulation for auditory comprehension deficits in post-stroke aphasia
title_fullStr Advances in theta-burst transcranial magnetic stimulation for auditory comprehension deficits in post-stroke aphasia
title_full_unstemmed Advances in theta-burst transcranial magnetic stimulation for auditory comprehension deficits in post-stroke aphasia
title_short Advances in theta-burst transcranial magnetic stimulation for auditory comprehension deficits in post-stroke aphasia
title_sort advances in theta burst transcranial magnetic stimulation for auditory comprehension deficits in post stroke aphasia
topic post-stroke aphasia
transcranial magnetic stimulation
auditory comprehension
theta burst stimulation
stroke
url https://www.frontiersin.org/articles/10.3389/fneur.2025.1610016/full
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AT wendongyang advancesinthetabursttranscranialmagneticstimulationforauditorycomprehensiondeficitsinpoststrokeaphasia
AT hongzhang advancesinthetabursttranscranialmagneticstimulationforauditorycomprehensiondeficitsinpoststrokeaphasia
AT lianxidong advancesinthetabursttranscranialmagneticstimulationforauditorycomprehensiondeficitsinpoststrokeaphasia
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