COMBINATION THERAPY WITH ATENOLOL AND AMLODIPINE AND CORRECTION OF CARDIOVASCULAR AUTONOMIC DYSFUNCTION IN PATIENTS WITH ARTERIAL HYPERTENSION
Aim. To assess the effects of the combination therapy with atenolol and amlodipine on the synchronisation of 0,1-Hz rhythms of heart rate variability (HRV) and distal vessel filling (DVF). Material and methods. The study included 25 patients with Stage 1–2 arterial hypertension (AH), aged 58±8 years...
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«FIRMA «SILICEA» LLC
2012-12-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/1306 |
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| author | A. R. Kiselev V. I. Gridnev A. S. Karavaev O. M. Posnenkova V. A. Shvartz V. I. Ponomarenko M. D. Prokhorov B. P. Bezruchko |
| author_facet | A. R. Kiselev V. I. Gridnev A. S. Karavaev O. M. Posnenkova V. A. Shvartz V. I. Ponomarenko M. D. Prokhorov B. P. Bezruchko |
| author_sort | A. R. Kiselev |
| collection | DOAJ |
| description | Aim. To assess the effects of the combination therapy with atenolol and amlodipine on the synchronisation of 0,1-Hz rhythms of heart rate variability (HRV) and distal vessel filling (DVF). Material and methods. The study included 25 patients with Stage 1–2 arterial hypertension (AH), aged 58±8 years. The registration of 0,1-Hz oscillations in HRV and DVF was performed during the passive tilt test with spontaneous breathing; each test stage lasted for 10 minutes. Synchronisation was assessed by the phase difference between 0.1 Hz-rhythms in HRV and DVF. Frequency values of the HRV spectrum in LF and HF-ranges were also assessed. The duration of combination therapy was 8 weeks. Results. In patients with AH and a markedly manifested autonomic dysfunction, the therapy with atenolol and amlodipine was associated with some improvement in the functional interaction between HRV and DVF 0,1-Hz rhythms. In the rest of AH patients, the treatment was linked to stable levels of cardiac 0,1-Hz regulation and slightly decreased synchronisation levels. All participants demonstrated an increase in the influence of respiratory parasympathetic effects. Conclusion. The combination therapy with atenolol and amlodipine effectively corrected autonomic cardiovascular dysfunction in patients with Stage 1–2 AH. |
| format | Article |
| id | doaj-art-22c3cfd3e56f405ea1073a4abb596c7f |
| institution | DOAJ |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2012-12-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-22c3cfd3e56f405ea1073a4abb596c7f2025-08-20T02:59:39Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202012-12-010666711098COMBINATION THERAPY WITH ATENOLOL AND AMLODIPINE AND CORRECTION OF CARDIOVASCULAR AUTONOMIC DYSFUNCTION IN PATIENTS WITH ARTERIAL HYPERTENSIONA. R. Kiselev0V. I. Gridnev1A. S. Karavaev2O. M. Posnenkova3V. A. Shvartz4V. I. Ponomarenko5M. D. Prokhorov6B. P. Bezruchko7Saratov Research Institute of CardiologySaratov Research Institute of CardiologyN. G. Chernyshevskyi Saratov State University, Faculty of Nano- and Biomedical TechnologySaratov Research Institute of CardiologySaratov Research Institute of CardiologySaratov Branch, Institute of Radio Engineering and Electronics, Russian Academy of Sciences, SaratovSaratov Branch, Institute of Radio Engineering and Electronics, Russian Academy of Sciences, SaratovN. G. Chernyshevskyi Saratov State University, Faculty of Nano- and Biomedical TechnologyAim. To assess the effects of the combination therapy with atenolol and amlodipine on the synchronisation of 0,1-Hz rhythms of heart rate variability (HRV) and distal vessel filling (DVF). Material and methods. The study included 25 patients with Stage 1–2 arterial hypertension (AH), aged 58±8 years. The registration of 0,1-Hz oscillations in HRV and DVF was performed during the passive tilt test with spontaneous breathing; each test stage lasted for 10 minutes. Synchronisation was assessed by the phase difference between 0.1 Hz-rhythms in HRV and DVF. Frequency values of the HRV spectrum in LF and HF-ranges were also assessed. The duration of combination therapy was 8 weeks. Results. In patients with AH and a markedly manifested autonomic dysfunction, the therapy with atenolol and amlodipine was associated with some improvement in the functional interaction between HRV and DVF 0,1-Hz rhythms. In the rest of AH patients, the treatment was linked to stable levels of cardiac 0,1-Hz regulation and slightly decreased synchronisation levels. All participants demonstrated an increase in the influence of respiratory parasympathetic effects. Conclusion. The combination therapy with atenolol and amlodipine effectively corrected autonomic cardiovascular dysfunction in patients with Stage 1–2 AH.https://russjcardiol.elpub.ru/jour/article/view/1306autonomic regulationsynchronization0,1-hz rhythmtherapyatenololamlodipine |
| spellingShingle | A. R. Kiselev V. I. Gridnev A. S. Karavaev O. M. Posnenkova V. A. Shvartz V. I. Ponomarenko M. D. Prokhorov B. P. Bezruchko COMBINATION THERAPY WITH ATENOLOL AND AMLODIPINE AND CORRECTION OF CARDIOVASCULAR AUTONOMIC DYSFUNCTION IN PATIENTS WITH ARTERIAL HYPERTENSION Российский кардиологический журнал autonomic regulation synchronization 0,1-hz rhythm therapy atenolol amlodipine |
| title | COMBINATION THERAPY WITH ATENOLOL AND AMLODIPINE AND CORRECTION OF CARDIOVASCULAR AUTONOMIC DYSFUNCTION IN PATIENTS WITH ARTERIAL HYPERTENSION |
| title_full | COMBINATION THERAPY WITH ATENOLOL AND AMLODIPINE AND CORRECTION OF CARDIOVASCULAR AUTONOMIC DYSFUNCTION IN PATIENTS WITH ARTERIAL HYPERTENSION |
| title_fullStr | COMBINATION THERAPY WITH ATENOLOL AND AMLODIPINE AND CORRECTION OF CARDIOVASCULAR AUTONOMIC DYSFUNCTION IN PATIENTS WITH ARTERIAL HYPERTENSION |
| title_full_unstemmed | COMBINATION THERAPY WITH ATENOLOL AND AMLODIPINE AND CORRECTION OF CARDIOVASCULAR AUTONOMIC DYSFUNCTION IN PATIENTS WITH ARTERIAL HYPERTENSION |
| title_short | COMBINATION THERAPY WITH ATENOLOL AND AMLODIPINE AND CORRECTION OF CARDIOVASCULAR AUTONOMIC DYSFUNCTION IN PATIENTS WITH ARTERIAL HYPERTENSION |
| title_sort | combination therapy with atenolol and amlodipine and correction of cardiovascular autonomic dysfunction in patients with arterial hypertension |
| topic | autonomic regulation synchronization 0,1-hz rhythm therapy atenolol amlodipine |
| url | https://russjcardiol.elpub.ru/jour/article/view/1306 |
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