A young adult patient with Philadelphia positive acute lymphoblastic leukemia presenting with extreme hyperleukocytosis
Key Clinical Message Extreme hyperleukocytosis (Leukocyte count >200 × 109/L) in an adolescent young adult (AYA) patient with B‐ALL could result in mild symptoms of leukostasis. Hyperleukocytosis requires prompt initiation of therapy with adequate hydration, cytoreduction and prevention of tumor...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Clinical Case Reports |
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| Online Access: | https://doi.org/10.1002/ccr3.9512 |
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| author | Gulten Tikit Elif Yucesu Aliye Serpil Sarıfakıoglu Imdat Dilek Sule Mine Bakanay |
| author_facet | Gulten Tikit Elif Yucesu Aliye Serpil Sarıfakıoglu Imdat Dilek Sule Mine Bakanay |
| author_sort | Gulten Tikit |
| collection | DOAJ |
| description | Key Clinical Message Extreme hyperleukocytosis (Leukocyte count >200 × 109/L) in an adolescent young adult (AYA) patient with B‐ALL could result in mild symptoms of leukostasis. Hyperleukocytosis requires prompt initiation of therapy with adequate hydration, cytoreduction and prevention of tumor lysis. Ph + B‐ALL may present with extreme hyperleukocytosis and may be resistant to initial pre‐phase therapy. In such cases, leukocytapheresis is beneficial in reducing the leukocyte count as well as controlling the symptoms. |
| format | Article |
| id | doaj-art-22c0bde7ad724cff8057f1c0dffd3790 |
| institution | Kabale University |
| issn | 2050-0904 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj-art-22c0bde7ad724cff8057f1c0dffd37902025-01-24T05:08:45ZengWileyClinical Case Reports2050-09042025-01-01131n/an/a10.1002/ccr3.9512A young adult patient with Philadelphia positive acute lymphoblastic leukemia presenting with extreme hyperleukocytosisGulten Tikit0Elif Yucesu1Aliye Serpil Sarıfakıoglu2Imdat Dilek3Sule Mine Bakanay4Department of Hematology, Ankara Yıldırım Beyazıt University Faculty of Medicine Ankara Bilkent City Hospital Ankara TurkeyAnkara Bilkent City Hospital Hematology Clinics Ankara TurkeyAnkara Bilkent City Hospital Hematology Clinics Ankara TurkeyDepartment of Hematology, Ankara Yıldırım Beyazıt University Faculty of Medicine Ankara Bilkent City Hospital Ankara TurkeyDepartment of Hematology, Ankara Yıldırım Beyazıt University Faculty of Medicine Ankara Bilkent City Hospital Ankara TurkeyKey Clinical Message Extreme hyperleukocytosis (Leukocyte count >200 × 109/L) in an adolescent young adult (AYA) patient with B‐ALL could result in mild symptoms of leukostasis. Hyperleukocytosis requires prompt initiation of therapy with adequate hydration, cytoreduction and prevention of tumor lysis. Ph + B‐ALL may present with extreme hyperleukocytosis and may be resistant to initial pre‐phase therapy. In such cases, leukocytapheresis is beneficial in reducing the leukocyte count as well as controlling the symptoms.https://doi.org/10.1002/ccr3.9512acute lymphoblastic leukemia (ALL)case reporthyperleukocytosisleukocytapheresisleukostasisPhiladelphia (Ph+) |
| spellingShingle | Gulten Tikit Elif Yucesu Aliye Serpil Sarıfakıoglu Imdat Dilek Sule Mine Bakanay A young adult patient with Philadelphia positive acute lymphoblastic leukemia presenting with extreme hyperleukocytosis Clinical Case Reports acute lymphoblastic leukemia (ALL) case report hyperleukocytosis leukocytapheresis leukostasis Philadelphia (Ph+) |
| title | A young adult patient with Philadelphia positive acute lymphoblastic leukemia presenting with extreme hyperleukocytosis |
| title_full | A young adult patient with Philadelphia positive acute lymphoblastic leukemia presenting with extreme hyperleukocytosis |
| title_fullStr | A young adult patient with Philadelphia positive acute lymphoblastic leukemia presenting with extreme hyperleukocytosis |
| title_full_unstemmed | A young adult patient with Philadelphia positive acute lymphoblastic leukemia presenting with extreme hyperleukocytosis |
| title_short | A young adult patient with Philadelphia positive acute lymphoblastic leukemia presenting with extreme hyperleukocytosis |
| title_sort | young adult patient with philadelphia positive acute lymphoblastic leukemia presenting with extreme hyperleukocytosis |
| topic | acute lymphoblastic leukemia (ALL) case report hyperleukocytosis leukocytapheresis leukostasis Philadelphia (Ph+) |
| url | https://doi.org/10.1002/ccr3.9512 |
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