Synthesis, <i>In Vitro</i> and <i>In Silico</i> Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents
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| Format: | Article |
| Language: | English |
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Georg Thieme Verlag KG
2025-02-01
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| Series: | SynOpen |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1775424 |
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| author | Wael Shehta Norah A. Alsaiari Basant Farag Marwa M. Abdel-Aziz Shaker Youssif Sherin M Elfeky Samar El-Kalyoubi Nermine A. Osman |
| author_facet | Wael Shehta Norah A. Alsaiari Basant Farag Marwa M. Abdel-Aziz Shaker Youssif Sherin M Elfeky Samar El-Kalyoubi Nermine A. Osman |
| author_sort | Wael Shehta |
| collection | DOAJ |
| format | Article |
| id | doaj-art-22bf4ef0c85340128673e4dc2715e5a7 |
| institution | Kabale University |
| issn | 2509-9396 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Georg Thieme Verlag KG |
| record_format | Article |
| series | SynOpen |
| spelling | doaj-art-22bf4ef0c85340128673e4dc2715e5a72025-02-11T00:08:18ZengGeorg Thieme Verlag KGSynOpen2509-93962025-02-010901738310.1055/s-0043-1775424Synthesis, <i>In Vitro</i> and <i>In Silico</i> Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular AgentsWael Shehta0Norah A. Alsaiari1Basant Farag2Marwa M. Abdel-Aziz3Shaker Youssif4https://orcid.org/0000-0003-2623-0261Sherin M Elfeky5Samar El-Kalyoubi6Nermine A. Osman7Department of Chemistry, Faculty of Science, Zagazig UniversityDepartment of Chemistry, Faculty of Science and Arts at Sharurah, Najran UniversityDepartment of Chemistry, Faculty of Science, Zagazig UniversityMedical Microbiology at the Regional Center for Mycology and Biotechnology, Al-Azhar UniversityDepartment of Chemistry, Faculty of Science, Zagazig UniversityPharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura UniversityPharmaceutical Organic Chemistry, Faculty of Pharmacy, Port Said UniversityPharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig Universityhttp://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1775424 Mycobacterium tuberculosis ADMET studiesdocking simulationenzyme inhibitionphthalimide–pyrimidine hybrids |
| spellingShingle | Wael Shehta Norah A. Alsaiari Basant Farag Marwa M. Abdel-Aziz Shaker Youssif Sherin M Elfeky Samar El-Kalyoubi Nermine A. Osman Synthesis, <i>In Vitro</i> and <i>In Silico</i> Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents SynOpen Mycobacterium tuberculosis ADMET studies docking simulation enzyme inhibition phthalimide–pyrimidine hybrids |
| title | Synthesis, <i>In Vitro</i> and <i>In Silico</i> Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents |
| title_full | Synthesis, <i>In Vitro</i> and <i>In Silico</i> Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents |
| title_fullStr | Synthesis, <i>In Vitro</i> and <i>In Silico</i> Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents |
| title_full_unstemmed | Synthesis, <i>In Vitro</i> and <i>In Silico</i> Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents |
| title_short | Synthesis, <i>In Vitro</i> and <i>In Silico</i> Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents |
| title_sort | synthesis i in vitro i and i in silico i molecular docking studies of novel phthalimide pyrimidine hybrid analogues to thalidomide as potent antitubercular agents |
| topic | Mycobacterium tuberculosis ADMET studies docking simulation enzyme inhibition phthalimide–pyrimidine hybrids |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1775424 |
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