Oxidative stress in viral hepatitis
Viral hepatitis, primarily caused by hepatitis B virus (HBV) and hepatitis C virus (HCV), is a leading cause of chronic liver disease worldwide. Accumulating evidence suggests that oxidative stress (OS) plays a pivotal role in the pathogenesis and progression of viral hepatitis. OS occurs due to a...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Society of Turaz Bilim
2024-04-01
|
| Series: | Medicine Science |
| Subjects: | |
| Online Access: | https://www.medicinescience.org/?mno=217705 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825206461915987968 |
|---|---|
| author | Huseyin Erdal Hacer Ozlem Kalayci |
| author_facet | Huseyin Erdal Hacer Ozlem Kalayci |
| author_sort | Huseyin Erdal |
| collection | DOAJ |
| description | Viral hepatitis, primarily caused by hepatitis B virus (HBV) and hepatitis C virus (HCV), is a leading cause of chronic liver disease worldwide. Accumulating evidence suggests that oxidative stress (OS) plays a pivotal role in the pathogenesis and progression of viral hepatitis. OS occurs due to a disproportion between reactive oxygen species (ROS) generation and antioxidant protection, resulting in damage to cells and tissues. In viral hepatitis, viral proteins and immune-mediated inflammatory responses contribute to excessive ROS generation, resulting in oxidative damage to hepatocytes. This damage manifests as lipid peroxidation, DNA damage, and protein oxidation, which in turn promote hepatic inflammation, fibrosis, and hepatocellular carcinoma. Furthermore, OS has been implicated in the resistance to antiviral therapy observed in some patients. This review highlights the molecular mechanisms underlying OS in viral hepatitis, its contribution to liver disease progression, and its impact on treatment outcomes. Understanding these mechanisms may open new avenues for therapeutic strategies targeting OS, thereby improving the management of viral hepatitis and associated liver diseases. [Med-Science 2024; 13(4.000): 1027-9] |
| format | Article |
| id | doaj-art-22bd533ee2f74fbaa79ef1cf3bdd3be7 |
| institution | Kabale University |
| issn | 2147-0634 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Society of Turaz Bilim |
| record_format | Article |
| series | Medicine Science |
| spelling | doaj-art-22bd533ee2f74fbaa79ef1cf3bdd3be72025-02-07T08:49:24ZengSociety of Turaz BilimMedicine Science2147-06342024-04-011341027910.5455/medscience.2024.08.104217705Oxidative stress in viral hepatitisHuseyin Erdal0Hacer Ozlem Kalayci1Department of Medical Genetics, Aksaray University, Faculty of Medicine, Aksaray, Turkiye Department of Medical Microbiology, Ordu University, Faculty of Medicine, Ordu, TürkiyeViral hepatitis, primarily caused by hepatitis B virus (HBV) and hepatitis C virus (HCV), is a leading cause of chronic liver disease worldwide. Accumulating evidence suggests that oxidative stress (OS) plays a pivotal role in the pathogenesis and progression of viral hepatitis. OS occurs due to a disproportion between reactive oxygen species (ROS) generation and antioxidant protection, resulting in damage to cells and tissues. In viral hepatitis, viral proteins and immune-mediated inflammatory responses contribute to excessive ROS generation, resulting in oxidative damage to hepatocytes. This damage manifests as lipid peroxidation, DNA damage, and protein oxidation, which in turn promote hepatic inflammation, fibrosis, and hepatocellular carcinoma. Furthermore, OS has been implicated in the resistance to antiviral therapy observed in some patients. This review highlights the molecular mechanisms underlying OS in viral hepatitis, its contribution to liver disease progression, and its impact on treatment outcomes. Understanding these mechanisms may open new avenues for therapeutic strategies targeting OS, thereby improving the management of viral hepatitis and associated liver diseases. [Med-Science 2024; 13(4.000): 1027-9]https://www.medicinescience.org/?mno=217705oxidative stress; viral hepatitis; hepatitis c |
| spellingShingle | Huseyin Erdal Hacer Ozlem Kalayci Oxidative stress in viral hepatitis Medicine Science oxidative stress; viral hepatitis; hepatitis c |
| title | Oxidative stress in viral hepatitis |
| title_full | Oxidative stress in viral hepatitis |
| title_fullStr | Oxidative stress in viral hepatitis |
| title_full_unstemmed | Oxidative stress in viral hepatitis |
| title_short | Oxidative stress in viral hepatitis |
| title_sort | oxidative stress in viral hepatitis |
| topic | oxidative stress; viral hepatitis; hepatitis c |
| url | https://www.medicinescience.org/?mno=217705 |
| work_keys_str_mv | AT huseyinerdal oxidativestressinviralhepatitis AT hacerozlemkalayci oxidativestressinviralhepatitis |