Impact of HIV Infection and Zidovudine Therapy on RBC Parameters and Urine Methylmalonic Acid Levels
Background. Anaemia is a common complication of human immunodeficiency virus (HIV) infection. The aim of this study was to investigate the impact of HIV infection and zidovudine on red blood cells (RBC) parameters and urine methylmalonic acid (UMMA) levels in patients with HIV infection. Material an...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2016/5210963 |
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| author | Adewumi Adediran Vincent Osunkalu Tamunomieibi Wakama Sarah John-Olabode Akinsegun Akinbami Ebele Uche Sulaimon Akanmu |
| author_facet | Adewumi Adediran Vincent Osunkalu Tamunomieibi Wakama Sarah John-Olabode Akinsegun Akinbami Ebele Uche Sulaimon Akanmu |
| author_sort | Adewumi Adediran |
| collection | DOAJ |
| description | Background. Anaemia is a common complication of human immunodeficiency virus (HIV) infection. The aim of this study was to investigate the impact of HIV infection and zidovudine on red blood cells (RBC) parameters and urine methylmalonic acid (UMMA) levels in patients with HIV infection. Material and Methods. A cross-sectional study involving 114 subjects, 94 of which are HIV-infected nonanaemic and 20 HIV negative subjects (Cg) as control. Full blood count parameters and urine methylmalonic acid (UMMA) level of each subject were determined. Associations were determined by Chi-square test and logistic regression statistics where appropriate. Results. Subjects on zidovudine-based ART had mean MCV (93 fL) higher than that of control group (82.9 fL) and ART-naïve (85.9 fL) subjects and the highest mean RDW. Mean UMMA level, which reflects vitamin B12 level status, was high in all HIV-infected groups but was significantly higher in ART-naïve subjects than in ART-experienced subjects. Conclusion. Although non-zidovudine therapy may be associated with macrocytosis (MCV > 95 fL), zidovudine therapy and ART naivety may not. Suboptimal level of vitamin B12 as measured by high UMMA though highest in ART-naïve subjects was common in all HIV-infected subjects. |
| format | Article |
| id | doaj-art-22b6ca0fa9be4efba07a18a3dea95b40 |
| institution | Kabale University |
| issn | 1687-708X 1687-7098 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-22b6ca0fa9be4efba07a18a3dea95b402025-08-20T03:54:48ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-708X1687-70982016-01-01201610.1155/2016/52109635210963Impact of HIV Infection and Zidovudine Therapy on RBC Parameters and Urine Methylmalonic Acid LevelsAdewumi Adediran0Vincent Osunkalu1Tamunomieibi Wakama2Sarah John-Olabode3Akinsegun Akinbami4Ebele Uche5Sulaimon Akanmu6Department of Haematology and Blood Transfusion, College of Medicine, University of Lagos, Idi-Araba, Lagos 100254, NigeriaDepartment of Haematology and Blood Transfusion, College of Medicine, University of Lagos, Idi-Araba, Lagos 100254, NigeriaDepartment of Haematology and Blood Transfusion, National Hospital, Abuja 900241, NigeriaDepartment of Haematology and Blood Transfusion, College of Medicine, University of Lagos, Idi-Araba, Lagos 100254, NigeriaDepartment of Haematology and Blood Transfusion, Lagos State University Teaching Hospital, Ikeja, Lagos 100271, NigeriaDepartment of Haematology and Blood Transfusion, Lagos State University Teaching Hospital, Ikeja, Lagos 100271, NigeriaDepartment of Haematology and Blood Transfusion, College of Medicine, University of Lagos, Idi-Araba, Lagos 100254, NigeriaBackground. Anaemia is a common complication of human immunodeficiency virus (HIV) infection. The aim of this study was to investigate the impact of HIV infection and zidovudine on red blood cells (RBC) parameters and urine methylmalonic acid (UMMA) levels in patients with HIV infection. Material and Methods. A cross-sectional study involving 114 subjects, 94 of which are HIV-infected nonanaemic and 20 HIV negative subjects (Cg) as control. Full blood count parameters and urine methylmalonic acid (UMMA) level of each subject were determined. Associations were determined by Chi-square test and logistic regression statistics where appropriate. Results. Subjects on zidovudine-based ART had mean MCV (93 fL) higher than that of control group (82.9 fL) and ART-naïve (85.9 fL) subjects and the highest mean RDW. Mean UMMA level, which reflects vitamin B12 level status, was high in all HIV-infected groups but was significantly higher in ART-naïve subjects than in ART-experienced subjects. Conclusion. Although non-zidovudine therapy may be associated with macrocytosis (MCV > 95 fL), zidovudine therapy and ART naivety may not. Suboptimal level of vitamin B12 as measured by high UMMA though highest in ART-naïve subjects was common in all HIV-infected subjects.http://dx.doi.org/10.1155/2016/5210963 |
| spellingShingle | Adewumi Adediran Vincent Osunkalu Tamunomieibi Wakama Sarah John-Olabode Akinsegun Akinbami Ebele Uche Sulaimon Akanmu Impact of HIV Infection and Zidovudine Therapy on RBC Parameters and Urine Methylmalonic Acid Levels Interdisciplinary Perspectives on Infectious Diseases |
| title | Impact of HIV Infection and Zidovudine Therapy on RBC Parameters and Urine Methylmalonic Acid Levels |
| title_full | Impact of HIV Infection and Zidovudine Therapy on RBC Parameters and Urine Methylmalonic Acid Levels |
| title_fullStr | Impact of HIV Infection and Zidovudine Therapy on RBC Parameters and Urine Methylmalonic Acid Levels |
| title_full_unstemmed | Impact of HIV Infection and Zidovudine Therapy on RBC Parameters and Urine Methylmalonic Acid Levels |
| title_short | Impact of HIV Infection and Zidovudine Therapy on RBC Parameters and Urine Methylmalonic Acid Levels |
| title_sort | impact of hiv infection and zidovudine therapy on rbc parameters and urine methylmalonic acid levels |
| url | http://dx.doi.org/10.1155/2016/5210963 |
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