Electrophysiological Markers of Chemotherapy-Induced Polyneuropathy
Introduction. Electrophysiological testing is the gold standard for diagnosing polyneuropathy. However, its use in oncology practice for patients with chemotherapy-induced polyneuropathy (CIPN) remains limited and the value of its findings is not fully understood. The study was aimed at identifyi...
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Research Center of Neurology
2025-06-01
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| Series: | Анналы клинической и экспериментальной неврологии |
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| Online Access: | https://annaly-nevrologii.com/pathID/article/viewFile/1283/pdf |
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| author | Olga A. Tikhonova Evgeniia S. Druzhinina Dmitry S. Druzhinin |
| author_facet | Olga A. Tikhonova Evgeniia S. Druzhinina Dmitry S. Druzhinin |
| author_sort | Olga A. Tikhonova |
| collection | DOAJ |
| description | Introduction. Electrophysiological testing is the gold standard for diagnosing polyneuropathy. However, its use in oncology practice for patients with chemotherapy-induced polyneuropathy (CIPN) remains limited and the value of its findings is not fully understood.
The study was aimed at identifying electrophysiological CIPN markers and evaluting their sensitivity and specificity.
Materials and methods. The study included patients (n = 71) over 18 years of age with solid tumor presenting with polyneuritic complaints following neurotoxic therapy with platinum-based agents and taxanes. Patients with known risk factors for polyneuropathy were excluded. Electrophysiological and clinical patient data were evaluated no earlier than 3 months following chemotherapy initiation.
Results. The study identified electromyographic markers: SRAR index (sural/radial ratio — the ratio between the action potential amplitudes of the sural and radial nerves) and the sural nerve action potential (SNAP), demonstrating equal sensitivity (73.7%) and high specificity (75% and 84.6%, respectively).
Conclusion. Electromyographic parameters such as SRAR and SNAP sural nerve can be utilized for the diagnosis and monitoring of CIPN in daily practice. |
| format | Article |
| id | doaj-art-22b3d026007e4975ae0db85e9c19b67c |
| institution | Kabale University |
| issn | 2075-5473 2409-2533 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Research Center of Neurology |
| record_format | Article |
| series | Анналы клинической и экспериментальной неврологии |
| spelling | doaj-art-22b3d026007e4975ae0db85e9c19b67c2025-08-20T03:40:50ZengResearch Center of NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-25332025-06-01192344010.17816/ACEN.1283742Electrophysiological Markers of Chemotherapy-Induced PolyneuropathyOlga A. Tikhonova0https://orcid.org/0000-0002-1796-0193Evgeniia S. Druzhinina1https://orcid.org/0000-0002-1004-992XDmitry S. Druzhinin2https://orcid.org/0000-0002-6244-0867Immanuel Kant Baltic Federal UniversityPirogov Russian National Research Medical UniversityYaroslavl State Medical UniversityIntroduction. Electrophysiological testing is the gold standard for diagnosing polyneuropathy. However, its use in oncology practice for patients with chemotherapy-induced polyneuropathy (CIPN) remains limited and the value of its findings is not fully understood. The study was aimed at identifying electrophysiological CIPN markers and evaluting their sensitivity and specificity. Materials and methods. The study included patients (n = 71) over 18 years of age with solid tumor presenting with polyneuritic complaints following neurotoxic therapy with platinum-based agents and taxanes. Patients with known risk factors for polyneuropathy were excluded. Electrophysiological and clinical patient data were evaluated no earlier than 3 months following chemotherapy initiation. Results. The study identified electromyographic markers: SRAR index (sural/radial ratio — the ratio between the action potential amplitudes of the sural and radial nerves) and the sural nerve action potential (SNAP), demonstrating equal sensitivity (73.7%) and high specificity (75% and 84.6%, respectively). Conclusion. Electromyographic parameters such as SRAR and SNAP sural nerve can be utilized for the diagnosis and monitoring of CIPN in daily practice.https://annaly-nevrologii.com/pathID/article/viewFile/1283/pdfelectroneuromyographychemotherapy-induced polyneuropathymarkerssrarcancer |
| spellingShingle | Olga A. Tikhonova Evgeniia S. Druzhinina Dmitry S. Druzhinin Electrophysiological Markers of Chemotherapy-Induced Polyneuropathy Анналы клинической и экспериментальной неврологии electroneuromyography chemotherapy-induced polyneuropathy markers srar cancer |
| title | Electrophysiological Markers of Chemotherapy-Induced Polyneuropathy |
| title_full | Electrophysiological Markers of Chemotherapy-Induced Polyneuropathy |
| title_fullStr | Electrophysiological Markers of Chemotherapy-Induced Polyneuropathy |
| title_full_unstemmed | Electrophysiological Markers of Chemotherapy-Induced Polyneuropathy |
| title_short | Electrophysiological Markers of Chemotherapy-Induced Polyneuropathy |
| title_sort | electrophysiological markers of chemotherapy induced polyneuropathy |
| topic | electroneuromyography chemotherapy-induced polyneuropathy markers srar cancer |
| url | https://annaly-nevrologii.com/pathID/article/viewFile/1283/pdf |
| work_keys_str_mv | AT olgaatikhonova electrophysiologicalmarkersofchemotherapyinducedpolyneuropathy AT evgeniiasdruzhinina electrophysiologicalmarkersofchemotherapyinducedpolyneuropathy AT dmitrysdruzhinin electrophysiologicalmarkersofchemotherapyinducedpolyneuropathy |