Factors affecting postural instability after more than one-year bilateral subthalamic stimulation in Parkinson's disease: A cross-sectional study.
<h4>Background</h4>Balance impairment in Parkinson's disease is multifactorial and its changes due to subthalamic stimulation vary in different studies.<h4>Objective</h4>We aimed to analyze the combination of predictive clinical factors of balance impairment in patients...
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0264114&type=printable |
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| author | Andrea Kelemen László Halász Loránd Erőss Gábor Rudas Muthuraman Muthuraman Dénes Zádori Bence Laczó Dávid Kis Péter Klivényi Gábor Fekete László Bognár Dániel Bereczki Gertrúd Tamás |
| author_facet | Andrea Kelemen László Halász Loránd Erőss Gábor Rudas Muthuraman Muthuraman Dénes Zádori Bence Laczó Dávid Kis Péter Klivényi Gábor Fekete László Bognár Dániel Bereczki Gertrúd Tamás |
| author_sort | Andrea Kelemen |
| collection | DOAJ |
| description | <h4>Background</h4>Balance impairment in Parkinson's disease is multifactorial and its changes due to subthalamic stimulation vary in different studies.<h4>Objective</h4>We aimed to analyze the combination of predictive clinical factors of balance impairment in patients with Parkinson's disease treated with bilateral subthalamic stimulation for at least one year.<h4>Methods</h4>We recruited 24 patients with Parkinson's disease treated with bilateral subthalamic stimulation and 24 healthy controls. They wore an Opal monitor (APDM Inc.) consisting of three-dimensional gyroscopes and accelerometers in the lumbar region. We investigated four stimulation conditions (bilateral stimulation OFF, bilateral stimulation ON, and unilateral right- and left-sided stimulation ON) with four tests: stance on a plain ground with eyes open and closed, stance on a foam platform with eyes open and closed. Age, disease duration, the time elapsed after implantation, levodopa, and stimulation responsiveness were analyzed. The distance of stimulation location from the subthalamic motor center was calculated individually in each plane of the three dimensions. We analyzed the sway values in the four stimulation conditions in the patient group and compared them with the control values. We explored factor combinations (with age as confounder) in the patient group predictive for imbalance with cluster analysis and a machine-learning-based multiple regression method.<h4>Results</h4>Sway combined from the four tasks did not differ in the patients and controls on a group level. The combination of the disease duration, the preoperative levodopa responsiveness, and the stimulation responsiveness predicted individual stimulation-induced static imbalance. The more affected patients had more severe motor symptoms; primarily, the proprioceptive followed by visual sensory feedback loss provoked imbalance in them when switching on the stimulation.<h4>Conclusions</h4>The duration of the disease, the severity of motor symptoms, the levodopa responsiveness, and additional sensory deficits should be carefully considered during preoperative evaluation to predict subthalamic stimulation-induced imbalance in Parkinson's disease. |
| format | Article |
| id | doaj-art-22b31418bbac4fbd98860f5fc059fa65 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-22b31418bbac4fbd98860f5fc059fa652025-08-20T03:15:48ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01172e026411410.1371/journal.pone.0264114Factors affecting postural instability after more than one-year bilateral subthalamic stimulation in Parkinson's disease: A cross-sectional study.Andrea KelemenLászló HalászLoránd ErőssGábor RudasMuthuraman MuthuramanDénes ZádoriBence LaczóDávid KisPéter KlivényiGábor FeketeLászló BognárDániel BereczkiGertrúd Tamás<h4>Background</h4>Balance impairment in Parkinson's disease is multifactorial and its changes due to subthalamic stimulation vary in different studies.<h4>Objective</h4>We aimed to analyze the combination of predictive clinical factors of balance impairment in patients with Parkinson's disease treated with bilateral subthalamic stimulation for at least one year.<h4>Methods</h4>We recruited 24 patients with Parkinson's disease treated with bilateral subthalamic stimulation and 24 healthy controls. They wore an Opal monitor (APDM Inc.) consisting of three-dimensional gyroscopes and accelerometers in the lumbar region. We investigated four stimulation conditions (bilateral stimulation OFF, bilateral stimulation ON, and unilateral right- and left-sided stimulation ON) with four tests: stance on a plain ground with eyes open and closed, stance on a foam platform with eyes open and closed. Age, disease duration, the time elapsed after implantation, levodopa, and stimulation responsiveness were analyzed. The distance of stimulation location from the subthalamic motor center was calculated individually in each plane of the three dimensions. We analyzed the sway values in the four stimulation conditions in the patient group and compared them with the control values. We explored factor combinations (with age as confounder) in the patient group predictive for imbalance with cluster analysis and a machine-learning-based multiple regression method.<h4>Results</h4>Sway combined from the four tasks did not differ in the patients and controls on a group level. The combination of the disease duration, the preoperative levodopa responsiveness, and the stimulation responsiveness predicted individual stimulation-induced static imbalance. The more affected patients had more severe motor symptoms; primarily, the proprioceptive followed by visual sensory feedback loss provoked imbalance in them when switching on the stimulation.<h4>Conclusions</h4>The duration of the disease, the severity of motor symptoms, the levodopa responsiveness, and additional sensory deficits should be carefully considered during preoperative evaluation to predict subthalamic stimulation-induced imbalance in Parkinson's disease.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0264114&type=printable |
| spellingShingle | Andrea Kelemen László Halász Loránd Erőss Gábor Rudas Muthuraman Muthuraman Dénes Zádori Bence Laczó Dávid Kis Péter Klivényi Gábor Fekete László Bognár Dániel Bereczki Gertrúd Tamás Factors affecting postural instability after more than one-year bilateral subthalamic stimulation in Parkinson's disease: A cross-sectional study. PLoS ONE |
| title | Factors affecting postural instability after more than one-year bilateral subthalamic stimulation in Parkinson's disease: A cross-sectional study. |
| title_full | Factors affecting postural instability after more than one-year bilateral subthalamic stimulation in Parkinson's disease: A cross-sectional study. |
| title_fullStr | Factors affecting postural instability after more than one-year bilateral subthalamic stimulation in Parkinson's disease: A cross-sectional study. |
| title_full_unstemmed | Factors affecting postural instability after more than one-year bilateral subthalamic stimulation in Parkinson's disease: A cross-sectional study. |
| title_short | Factors affecting postural instability after more than one-year bilateral subthalamic stimulation in Parkinson's disease: A cross-sectional study. |
| title_sort | factors affecting postural instability after more than one year bilateral subthalamic stimulation in parkinson s disease a cross sectional study |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0264114&type=printable |
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