Associations between MRI radiomics analysis and tumor-micro milieu in uterine cervical cancer
Abstract Purpose The complex interactions of the tumor micromilieu could be reflected by magnetic resonance imaging (MRI) when analyzed with the radiomics approach. For several tumor entities, it has been shown that radiomics derived from MRI can reflect important characteristics of the tumors. The...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2025-07-01
|
| Series: | Journal of Cancer Research and Clinical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s00432-025-06253-3 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849767195284865024 |
|---|---|
| author | Hans-Jonas Meyer Jakob Leonhardi Anne-Kathrin Höhn Noura Kabbani Silke Zimmermann Jan Borggrefe Alexey Surov |
| author_facet | Hans-Jonas Meyer Jakob Leonhardi Anne-Kathrin Höhn Noura Kabbani Silke Zimmermann Jan Borggrefe Alexey Surov |
| author_sort | Hans-Jonas Meyer |
| collection | DOAJ |
| description | Abstract Purpose The complex interactions of the tumor micromilieu could be reflected by magnetic resonance imaging (MRI) when analyzed with the radiomics approach. For several tumor entities, it has been shown that radiomics derived from MRI can reflect important characteristics of the tumors. The present study investigated the association radiomics derived from MRI images and histopathological features in uterine cervical cancer. Methods The MRI before any treatment was used to extract the radiomics features of T1- and T2-weighted images. The biopsy specimens were stained for Ki 67, e-cadherin, vimentin, programmed-death ligand 1, and tumor-infiltrating lymphocytes (TIL, all CD45 positive cells). Tumor-stroma ratio (TSR) was calculated on routine H&E specimen. Spearman’s correlation analysis and discrimination analyses were performed as statistical analyses. Results The patient sample was comprised of 89 female patients with a mean age of 49.3 years ± 14.6 (range 27–77 years) with squamous cell cervical carcinoma. “Kurtosis” derived from T1-weighted images after contrast media application correlated with the Ki-67 index (r = 0.28, p = 0.02). “WavEnHL_s-4” derived from T2-weighted images and “S(1.0)Contrast” derived from T1-weighted images after contrast media application showed correlations with TSR (r = − 0.24, p = 0.04, each). Several associations were identified between the radiomics features with immune scores defined by programmed-death ligand 1, the highest correlation showed Teta1 derived from T2-weighted images with the combined positive score (r = − 0.38, p < 0.01). There were several associations with vimentin expression, the highest showed “Variance” derived from T1-weighted images after contrast media application (r = 0.46, p < 0.01). Conclusions Radiomics features derived from MRI can reflect tumor characteristics of UCC. Especially immune-related features were reflected by the MRI texture features. Proliferation potential, composition of the extracellular matrix and tumor-stroma ratio were also significantly associated with radiomics features. These presented results need to be evaluated in an independent cohort to test their stability. |
| format | Article |
| id | doaj-art-22b19ed3a36242eba0d0ca1a5d40fac4 |
| institution | DOAJ |
| issn | 1432-1335 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Cancer Research and Clinical Oncology |
| spelling | doaj-art-22b19ed3a36242eba0d0ca1a5d40fac42025-08-20T03:04:18ZengSpringerJournal of Cancer Research and Clinical Oncology1432-13352025-07-01151711010.1007/s00432-025-06253-3Associations between MRI radiomics analysis and tumor-micro milieu in uterine cervical cancerHans-Jonas Meyer0Jakob Leonhardi1Anne-Kathrin Höhn2Noura Kabbani3Silke Zimmermann4Jan Borggrefe5Alexey Surov6Department of Diagnostic and Interventional Radiology, University Hospital LeipzigDepartment of Diagnostic and Interventional Radiology, University Hospital LeipzigInstitute of Pathology, University Hospital of LeipzigDepartment of Gynecology, University Hospital of LeipzigInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of LeipzigInstitute for Radiology, Neuroradiology and Nuclear Medicine, Johannes Wesling Hospital, Ruhr University BochumInstitute for Radiology, Neuroradiology and Nuclear Medicine, Johannes Wesling Hospital, Ruhr University BochumAbstract Purpose The complex interactions of the tumor micromilieu could be reflected by magnetic resonance imaging (MRI) when analyzed with the radiomics approach. For several tumor entities, it has been shown that radiomics derived from MRI can reflect important characteristics of the tumors. The present study investigated the association radiomics derived from MRI images and histopathological features in uterine cervical cancer. Methods The MRI before any treatment was used to extract the radiomics features of T1- and T2-weighted images. The biopsy specimens were stained for Ki 67, e-cadherin, vimentin, programmed-death ligand 1, and tumor-infiltrating lymphocytes (TIL, all CD45 positive cells). Tumor-stroma ratio (TSR) was calculated on routine H&E specimen. Spearman’s correlation analysis and discrimination analyses were performed as statistical analyses. Results The patient sample was comprised of 89 female patients with a mean age of 49.3 years ± 14.6 (range 27–77 years) with squamous cell cervical carcinoma. “Kurtosis” derived from T1-weighted images after contrast media application correlated with the Ki-67 index (r = 0.28, p = 0.02). “WavEnHL_s-4” derived from T2-weighted images and “S(1.0)Contrast” derived from T1-weighted images after contrast media application showed correlations with TSR (r = − 0.24, p = 0.04, each). Several associations were identified between the radiomics features with immune scores defined by programmed-death ligand 1, the highest correlation showed Teta1 derived from T2-weighted images with the combined positive score (r = − 0.38, p < 0.01). There were several associations with vimentin expression, the highest showed “Variance” derived from T1-weighted images after contrast media application (r = 0.46, p < 0.01). Conclusions Radiomics features derived from MRI can reflect tumor characteristics of UCC. Especially immune-related features were reflected by the MRI texture features. Proliferation potential, composition of the extracellular matrix and tumor-stroma ratio were also significantly associated with radiomics features. These presented results need to be evaluated in an independent cohort to test their stability.https://doi.org/10.1007/s00432-025-06253-3MRIRadiomicsCervical cancerTumor-stroma ratio |
| spellingShingle | Hans-Jonas Meyer Jakob Leonhardi Anne-Kathrin Höhn Noura Kabbani Silke Zimmermann Jan Borggrefe Alexey Surov Associations between MRI radiomics analysis and tumor-micro milieu in uterine cervical cancer Journal of Cancer Research and Clinical Oncology MRI Radiomics Cervical cancer Tumor-stroma ratio |
| title | Associations between MRI radiomics analysis and tumor-micro milieu in uterine cervical cancer |
| title_full | Associations between MRI radiomics analysis and tumor-micro milieu in uterine cervical cancer |
| title_fullStr | Associations between MRI radiomics analysis and tumor-micro milieu in uterine cervical cancer |
| title_full_unstemmed | Associations between MRI radiomics analysis and tumor-micro milieu in uterine cervical cancer |
| title_short | Associations between MRI radiomics analysis and tumor-micro milieu in uterine cervical cancer |
| title_sort | associations between mri radiomics analysis and tumor micro milieu in uterine cervical cancer |
| topic | MRI Radiomics Cervical cancer Tumor-stroma ratio |
| url | https://doi.org/10.1007/s00432-025-06253-3 |
| work_keys_str_mv | AT hansjonasmeyer associationsbetweenmriradiomicsanalysisandtumormicromilieuinuterinecervicalcancer AT jakobleonhardi associationsbetweenmriradiomicsanalysisandtumormicromilieuinuterinecervicalcancer AT annekathrinhohn associationsbetweenmriradiomicsanalysisandtumormicromilieuinuterinecervicalcancer AT nourakabbani associationsbetweenmriradiomicsanalysisandtumormicromilieuinuterinecervicalcancer AT silkezimmermann associationsbetweenmriradiomicsanalysisandtumormicromilieuinuterinecervicalcancer AT janborggrefe associationsbetweenmriradiomicsanalysisandtumormicromilieuinuterinecervicalcancer AT alexeysurov associationsbetweenmriradiomicsanalysisandtumormicromilieuinuterinecervicalcancer |