Development of binary technologies of radiotherapy of malignant neoplasms: condition and problems
The review is devoted to the problems of the development of binary technologies of radiation therapy - neutron and photon-capture therapy of malignant neoplasms. These technologies are based on the principle of “biological” targeting: irradiation of a tumor with pre-delivered special preparations in...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2017-10-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/970 |
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| author | Igor N. Sheino Pavel V. Izhevskij Alexey A. Lipengolts Victor N. Kulakov Alexander A. Wagner Evgeniya S. Sukhikh Valery A. Varlachev |
| author_facet | Igor N. Sheino Pavel V. Izhevskij Alexey A. Lipengolts Victor N. Kulakov Alexander A. Wagner Evgeniya S. Sukhikh Valery A. Varlachev |
| author_sort | Igor N. Sheino |
| collection | DOAJ |
| description | The review is devoted to the problems of the development of binary technologies of radiation therapy - neutron and photon-capture therapy of malignant neoplasms. These technologies are based on the principle of “biological” targeting: irradiation of a tumor with pre-delivered special preparations increasing energy release and the relative biological efficiency of primary radiation. The basis of methods, characteristics of sources of external irradiation and used preparations, and stages of development of technologies are described. The development and implementation of binary technologies attract a great number of researchers but are restrained by the shortage of operating sources of epithermal neutrons (reactors, neutron generators based on accelerators) and the lack of accurate radiation dosimetry planning systems that takes into account the dynamics and accumulation of drugs in tumors. |
| format | Article |
| id | doaj-art-22add4e964e942fdb48335a759a4f0a1 |
| institution | Kabale University |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2017-10-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-22add4e964e942fdb48335a759a4f0a12025-08-20T04:00:12ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842017-10-0116319220910.20538/1682-0363-2017-3-192-209722Development of binary technologies of radiotherapy of malignant neoplasms: condition and problemsIgor N. Sheino0Pavel V. Izhevskij1Alexey A. Lipengolts2Victor N. Kulakov3Alexander A. Wagner4Evgeniya S. Sukhikh5Valery A. Varlachev6A.I. Burnazian Federal Medical Biophysical CenterA.I. Burnazian Federal Medical Biophysical CenterA.I. Burnazian Federal Medical Biophysical CenterA.I. Burnazian Federal Medical Biophysical CenterNational Research Tomsk Polytechnic UniversityNational Research Tomsk Polytechnic University; Tomsk Regional Oncology CenterNational Research Tomsk Polytechnic UniversityThe review is devoted to the problems of the development of binary technologies of radiation therapy - neutron and photon-capture therapy of malignant neoplasms. These technologies are based on the principle of “biological” targeting: irradiation of a tumor with pre-delivered special preparations increasing energy release and the relative biological efficiency of primary radiation. The basis of methods, characteristics of sources of external irradiation and used preparations, and stages of development of technologies are described. The development and implementation of binary technologies attract a great number of researchers but are restrained by the shortage of operating sources of epithermal neutrons (reactors, neutron generators based on accelerators) and the lack of accurate radiation dosimetry planning systems that takes into account the dynamics and accumulation of drugs in tumors.https://bulletin.ssmu.ru/jour/article/view/970malignant neoplasmsneutron-capture therapyphoton-capture therapybinary technologies of radiotherapyboron-10gadoliniumgoldplatinum |
| spellingShingle | Igor N. Sheino Pavel V. Izhevskij Alexey A. Lipengolts Victor N. Kulakov Alexander A. Wagner Evgeniya S. Sukhikh Valery A. Varlachev Development of binary technologies of radiotherapy of malignant neoplasms: condition and problems Бюллетень сибирской медицины malignant neoplasms neutron-capture therapy photon-capture therapy binary technologies of radiotherapy boron-10 gadolinium gold platinum |
| title | Development of binary technologies of radiotherapy of malignant neoplasms: condition and problems |
| title_full | Development of binary technologies of radiotherapy of malignant neoplasms: condition and problems |
| title_fullStr | Development of binary technologies of radiotherapy of malignant neoplasms: condition and problems |
| title_full_unstemmed | Development of binary technologies of radiotherapy of malignant neoplasms: condition and problems |
| title_short | Development of binary technologies of radiotherapy of malignant neoplasms: condition and problems |
| title_sort | development of binary technologies of radiotherapy of malignant neoplasms condition and problems |
| topic | malignant neoplasms neutron-capture therapy photon-capture therapy binary technologies of radiotherapy boron-10 gadolinium gold platinum |
| url | https://bulletin.ssmu.ru/jour/article/view/970 |
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