A Procedural Overview of the Involvement of Small Molecules in the Nervous System in the Regulation of Bone Healing

Xuyan Wei,1,2 Mucong Li,1,2 Jiaqian You,1,2 Jiaxin Luo,1,2 Jingjie Zhai,1,2 Jiameng Zhang,1,2 Jian Feng,1,2 Hanchi Wang,1,2 Yanmin Zhou1,2 1Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin University, Changchun, 130021, People’s Republic of Chi...

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Main Authors: Wei X, Li M, You J, Luo J, Zhai J, Zhang J, Feng J, Wang H, Zhou Y
Format: Article
Language:English
Published: Dove Medical Press 2025-01-01
Series:International Journal of Nanomedicine
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Online Access:https://www.dovepress.com/a-procedural-overview-of-the-involvement-of-small-molecules-in-the-ner-peer-reviewed-fulltext-article-IJN
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author Wei X
Li M
You J
Luo J
Zhai J
Zhang J
Feng J
Wang H
Zhou Y
author_facet Wei X
Li M
You J
Luo J
Zhai J
Zhang J
Feng J
Wang H
Zhou Y
author_sort Wei X
collection DOAJ
description Xuyan Wei,1,2 Mucong Li,1,2 Jiaqian You,1,2 Jiaxin Luo,1,2 Jingjie Zhai,1,2 Jiameng Zhang,1,2 Jian Feng,1,2 Hanchi Wang,1,2 Yanmin Zhou1,2 1Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin University, Changchun, 130021, People’s Republic of China; 2Department of Oral Implantology, Hospital of Stomatology, Jilin University, Changchun, 130021, People’s Republic of ChinaCorrespondence: Hanchi Wang; Yanmin Zhou, Department of Oral Implantology, Hospital of Stomatology, Jilin University, Changchun, 130021, People’s Republic of China, Email whc23@jlu.edu.cn; zhouym@jlu.edu.cnAbstract: Clinically, a multitude of factors can contribute to the development of bone defects. In the process of bone healing, the nervous system plays a vital role in bone regeneration. Small molecules from the nervous system, such as neurotrophic factors and neuropeptides, have been found to stimulate osteoblast proliferation and differentiation by activating signaling pathways associated with bone calcification and angiogenesis. These small molecules play a crucial regulatory role at various stages of bone healing. The systematic release mechanism of small molecules within the nervous system through diverse bone tissue engineering materials holds significant clinical implications for the controlled regulation of the bone healing process. This review provides an overview of the involvement of various nervous system small molecules at different stages of bone healing and discusses their regulatory mechanisms, aiming to establish a theoretical foundation for programmed regulation in bone regeneration and design of replacement materials in bone tissue engineering.Keywords: nervous system, neurotrophin, neuropeptide, bone healing, procedural controlled release
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publisher Dove Medical Press
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series International Journal of Nanomedicine
spelling doaj-art-22ac843adc104f66b69bd5fcbac017842025-02-02T15:59:40ZengDove Medical PressInternational Journal of Nanomedicine1178-20132025-01-01Volume 201263128499760A Procedural Overview of the Involvement of Small Molecules in the Nervous System in the Regulation of Bone HealingWei XLi MYou JLuo JZhai JZhang JFeng JWang HZhou YXuyan Wei,1,2 Mucong Li,1,2 Jiaqian You,1,2 Jiaxin Luo,1,2 Jingjie Zhai,1,2 Jiameng Zhang,1,2 Jian Feng,1,2 Hanchi Wang,1,2 Yanmin Zhou1,2 1Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin University, Changchun, 130021, People’s Republic of China; 2Department of Oral Implantology, Hospital of Stomatology, Jilin University, Changchun, 130021, People’s Republic of ChinaCorrespondence: Hanchi Wang; Yanmin Zhou, Department of Oral Implantology, Hospital of Stomatology, Jilin University, Changchun, 130021, People’s Republic of China, Email whc23@jlu.edu.cn; zhouym@jlu.edu.cnAbstract: Clinically, a multitude of factors can contribute to the development of bone defects. In the process of bone healing, the nervous system plays a vital role in bone regeneration. Small molecules from the nervous system, such as neurotrophic factors and neuropeptides, have been found to stimulate osteoblast proliferation and differentiation by activating signaling pathways associated with bone calcification and angiogenesis. These small molecules play a crucial regulatory role at various stages of bone healing. The systematic release mechanism of small molecules within the nervous system through diverse bone tissue engineering materials holds significant clinical implications for the controlled regulation of the bone healing process. This review provides an overview of the involvement of various nervous system small molecules at different stages of bone healing and discusses their regulatory mechanisms, aiming to establish a theoretical foundation for programmed regulation in bone regeneration and design of replacement materials in bone tissue engineering.Keywords: nervous system, neurotrophin, neuropeptide, bone healing, procedural controlled releasehttps://www.dovepress.com/a-procedural-overview-of-the-involvement-of-small-molecules-in-the-ner-peer-reviewed-fulltext-article-IJNnervous systemneurotrophinneuropeptidebone healingprocedural controlled release
spellingShingle Wei X
Li M
You J
Luo J
Zhai J
Zhang J
Feng J
Wang H
Zhou Y
A Procedural Overview of the Involvement of Small Molecules in the Nervous System in the Regulation of Bone Healing
International Journal of Nanomedicine
nervous system
neurotrophin
neuropeptide
bone healing
procedural controlled release
title A Procedural Overview of the Involvement of Small Molecules in the Nervous System in the Regulation of Bone Healing
title_full A Procedural Overview of the Involvement of Small Molecules in the Nervous System in the Regulation of Bone Healing
title_fullStr A Procedural Overview of the Involvement of Small Molecules in the Nervous System in the Regulation of Bone Healing
title_full_unstemmed A Procedural Overview of the Involvement of Small Molecules in the Nervous System in the Regulation of Bone Healing
title_short A Procedural Overview of the Involvement of Small Molecules in the Nervous System in the Regulation of Bone Healing
title_sort procedural overview of the involvement of small molecules in the nervous system in the regulation of bone healing
topic nervous system
neurotrophin
neuropeptide
bone healing
procedural controlled release
url https://www.dovepress.com/a-procedural-overview-of-the-involvement-of-small-molecules-in-the-ner-peer-reviewed-fulltext-article-IJN
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