ASGR1 deficiency improves atherosclerosis but alters liver metabolism in ApoE-/- mice

ASGR1 deficiency improves atherosclerosis but alters liver metabolism in ApoE-/- mice

Abstract Abstract The asialoglycoprotein receptor 1 (ASGR1), a multivalent carbohydrate-binding receptor that primarily is responsible for recognizing and eliminating circulating glycoproteins with exposed galactose (Gal) or N-acetylgalactosamine (GalNAc) as terminal glycan residues, has been implic...

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Main Authors: Monika Svecla, Annalisa Moregola, Lorenzo Da Dalt, Jasmine Nour, Andrea Baragetti, Patrizia Uboldi, Alessandra Idini, Manfred Wuhrer, Giangiacomo Beretta, David Falck, Fabrizia Bonacina, Giuseppe Danilo Norata
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Cardiovascular Diabetology
Subjects:
Atherosclerosis
Asialoglycoprotein receptor 1
Cholesterol
Plaque composition
Liver metabolism
Online Access:https://doi.org/10.1186/s12933-024-02507-5
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