Association between attention-deficit/hyperactivity disorders and intestinal disorders: A systematic review and Meta-analysis
Abstract Patients with attention-deficit hyperactivity disorder (ADHD) reported significantly more constipation and flatulence than healthy controls. An altered gut microbiome can be associated with gastrointestinal symptoms. However, comprehensive information about associated risk of intestinal dis...
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Nature Portfolio
2025-06-01
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| Online Access: | https://doi.org/10.1038/s41598-025-04303-x |
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| author | Rita W. Y. Ng Zigui Chen Liuyue Yang Oscar W. H. Wong Agnes S.Y. Leung K. W. Tsui Natalie M.W. Kwok Lesley H.Y. Tang Peter M.H. Cheung Paul K. S. Chan Margaret Ip |
| author_facet | Rita W. Y. Ng Zigui Chen Liuyue Yang Oscar W. H. Wong Agnes S.Y. Leung K. W. Tsui Natalie M.W. Kwok Lesley H.Y. Tang Peter M.H. Cheung Paul K. S. Chan Margaret Ip |
| author_sort | Rita W. Y. Ng |
| collection | DOAJ |
| description | Abstract Patients with attention-deficit hyperactivity disorder (ADHD) reported significantly more constipation and flatulence than healthy controls. An altered gut microbiome can be associated with gastrointestinal symptoms. However, comprehensive information about associated risk of intestinal disorders and ADHD remains limited. A systematic review of the literature was therefore conducted to investigate the association between ADHD and different types of intestinal disorders. A total of 11 studies with 3,851,163 unique individuals, including 175 806 individuals with ADHD and 3 675 357 individuals without ADHD were included. The pooled OR of intestinal disorders for individuals with ADHD was 1.25 (95%CI, 0.75–2.07). A significant positive association was found between ADHD and irritable bowel syndrome (IBS) (OR 1.63 [95% CI 1.45–1.83]). Studies conducted in Eastern Mediterranean Region yielded a summary OR estimate that was higher than summary OR estimates in studies conducted in Region of the Americas, European Region and Western Pacific Region (3.03 [1.53–5.99] vs. 2.20 [1.05–4.63], 1.04 [0.44–2.41], 0.68 [0.25–1.87]), with p value 0.053, indicating a trend towards significance. High heterogeneity was observed. Our study supports association between ADHD and increased risk of IBS. Our study suggests an altered gut microbiome is the potential link that bridges gap between ADHD and intestinal disorder. |
| format | Article |
| id | doaj-art-22a80a0740384c0fb14856d75c193669 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-22a80a0740384c0fb14856d75c1936692025-08-20T03:10:28ZengNature PortfolioScientific Reports2045-23222025-06-0115111010.1038/s41598-025-04303-xAssociation between attention-deficit/hyperactivity disorders and intestinal disorders: A systematic review and Meta-analysisRita W. Y. Ng0Zigui Chen1Liuyue Yang2Oscar W. H. Wong3Agnes S.Y. Leung4K. W. Tsui5Natalie M.W. Kwok6Lesley H.Y. Tang7Peter M.H. Cheung8Paul K. S. Chan9Margaret Ip10Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, ShatinDepartment of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, ShatinDepartment of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, ShatinDepartment of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, ShatinDepartment of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, ShatinDepartment of Paediatrics and Adolescent Medicine, Alice Ho Miu Ling Nethersole Hospital, Hospital AuthorityFaculty of Medicine, The Chinese University of Hong Kong, Sha TinFaculty of Medicine, The Chinese University of Hong Kong, Sha TinFaculty of Medicine, The Chinese University of Hong Kong, Sha TinDepartment of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, ShatinDepartment of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, ShatinAbstract Patients with attention-deficit hyperactivity disorder (ADHD) reported significantly more constipation and flatulence than healthy controls. An altered gut microbiome can be associated with gastrointestinal symptoms. However, comprehensive information about associated risk of intestinal disorders and ADHD remains limited. A systematic review of the literature was therefore conducted to investigate the association between ADHD and different types of intestinal disorders. A total of 11 studies with 3,851,163 unique individuals, including 175 806 individuals with ADHD and 3 675 357 individuals without ADHD were included. The pooled OR of intestinal disorders for individuals with ADHD was 1.25 (95%CI, 0.75–2.07). A significant positive association was found between ADHD and irritable bowel syndrome (IBS) (OR 1.63 [95% CI 1.45–1.83]). Studies conducted in Eastern Mediterranean Region yielded a summary OR estimate that was higher than summary OR estimates in studies conducted in Region of the Americas, European Region and Western Pacific Region (3.03 [1.53–5.99] vs. 2.20 [1.05–4.63], 1.04 [0.44–2.41], 0.68 [0.25–1.87]), with p value 0.053, indicating a trend towards significance. High heterogeneity was observed. Our study supports association between ADHD and increased risk of IBS. Our study suggests an altered gut microbiome is the potential link that bridges gap between ADHD and intestinal disorder.https://doi.org/10.1038/s41598-025-04303-xAttention-deficit hyperactivity disorder (ADHD)Intestinal disordersMeta-analysis |
| spellingShingle | Rita W. Y. Ng Zigui Chen Liuyue Yang Oscar W. H. Wong Agnes S.Y. Leung K. W. Tsui Natalie M.W. Kwok Lesley H.Y. Tang Peter M.H. Cheung Paul K. S. Chan Margaret Ip Association between attention-deficit/hyperactivity disorders and intestinal disorders: A systematic review and Meta-analysis Scientific Reports Attention-deficit hyperactivity disorder (ADHD) Intestinal disorders Meta-analysis |
| title | Association between attention-deficit/hyperactivity disorders and intestinal disorders: A systematic review and Meta-analysis |
| title_full | Association between attention-deficit/hyperactivity disorders and intestinal disorders: A systematic review and Meta-analysis |
| title_fullStr | Association between attention-deficit/hyperactivity disorders and intestinal disorders: A systematic review and Meta-analysis |
| title_full_unstemmed | Association between attention-deficit/hyperactivity disorders and intestinal disorders: A systematic review and Meta-analysis |
| title_short | Association between attention-deficit/hyperactivity disorders and intestinal disorders: A systematic review and Meta-analysis |
| title_sort | association between attention deficit hyperactivity disorders and intestinal disorders a systematic review and meta analysis |
| topic | Attention-deficit hyperactivity disorder (ADHD) Intestinal disorders Meta-analysis |
| url | https://doi.org/10.1038/s41598-025-04303-x |
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