Toward a role for the acoustic field in cells interaction
Nanoscale motility of cells is a fundamental phenomenon, closely associated with biological status and response to environmental solicitations, whose investigation has disclosed new perspectives for the comprehension of cell behavior and fate. To investigate intracellular interactions, we designed a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Systems Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnsys.2025.1484769/full |
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| author | Marco Girasole Pier Francesco Moretti Angela Di Giannatale Virginia Di Paolo Angela Galardi Silvia Lampis Simone Dinarelli Giovanni Longo |
| author_facet | Marco Girasole Pier Francesco Moretti Angela Di Giannatale Virginia Di Paolo Angela Galardi Silvia Lampis Simone Dinarelli Giovanni Longo |
| author_sort | Marco Girasole |
| collection | DOAJ |
| description | Nanoscale motility of cells is a fundamental phenomenon, closely associated with biological status and response to environmental solicitations, whose investigation has disclosed new perspectives for the comprehension of cell behavior and fate. To investigate intracellular interactions, we designed an experiment to monitor movements of clusters of neuroblastoma cells (SH-SY5Y) growing on a nanomechanical oscillator (nanomotion sensor) suspended few hundreds of microns over the surface of a Petri dish where other neuroblastoma cells are freely moving. We observed that the free-to-move cells feel the presence of cells on the nearby nanosensor (at a distance of up to 300 microns) and migrate toward them, even in presence of environmental hampering factors, such as medium microflows. The interaction is bidirectional since, as evidenced by nanomotion sensing, the cells on the sensor enhance their motion when clusters of freely moving cells approach. Considering the geometry and environmental context, our observations extend beyond what can be explained by sensing of chemical trackers, suggesting the presence of other physical mechanisms. We hypothesize that the acoustic field generated by cell vibrations can have a role in the initial recognition between distant clusters. Integrating our findings with a suitable wave propagation model, we show that mechanical waves produced by cellular activity have sufficient energy to trigger mechanotransduction in target cells hundreds of microns away. This interaction can explain the observed distance-dependent patterns of cellular migration and motion alteration. Our results suggest that acoustic fields generated by cells can mediate cell-cell interaction and contribute to signaling and communication. |
| format | Article |
| id | doaj-art-22a4409e1e564495a2f0df9d0e1899d2 |
| institution | Kabale University |
| issn | 1662-5137 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Systems Neuroscience |
| spelling | doaj-art-22a4409e1e564495a2f0df9d0e1899d22025-08-20T03:31:02ZengFrontiers Media S.A.Frontiers in Systems Neuroscience1662-51372025-06-011910.3389/fnsys.2025.14847691484769Toward a role for the acoustic field in cells interactionMarco Girasole0Pier Francesco Moretti1Angela Di Giannatale2Virginia Di Paolo3Angela Galardi4Silvia Lampis5Simone Dinarelli6Giovanni Longo7Institute of Matter Structure, Italian National Research Council, ISM-CNR, Rome, ItalyDepartment of Earth System Sciences and Environmental Technologies, Consiglio Nazionale delle Ricerche, Rome, ItalyHematology/Oncology and Cell and Gene Therapy Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, ItalyHematology/Oncology and Cell and Gene Therapy Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, ItalyHematology/Oncology and Cell and Gene Therapy Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, ItalyHematology/Oncology and Cell and Gene Therapy Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, ItalyInstitute of Matter Structure, Italian National Research Council, ISM-CNR, Rome, ItalyInstitute of Matter Structure, Italian National Research Council, ISM-CNR, Rome, ItalyNanoscale motility of cells is a fundamental phenomenon, closely associated with biological status and response to environmental solicitations, whose investigation has disclosed new perspectives for the comprehension of cell behavior and fate. To investigate intracellular interactions, we designed an experiment to monitor movements of clusters of neuroblastoma cells (SH-SY5Y) growing on a nanomechanical oscillator (nanomotion sensor) suspended few hundreds of microns over the surface of a Petri dish where other neuroblastoma cells are freely moving. We observed that the free-to-move cells feel the presence of cells on the nearby nanosensor (at a distance of up to 300 microns) and migrate toward them, even in presence of environmental hampering factors, such as medium microflows. The interaction is bidirectional since, as evidenced by nanomotion sensing, the cells on the sensor enhance their motion when clusters of freely moving cells approach. Considering the geometry and environmental context, our observations extend beyond what can be explained by sensing of chemical trackers, suggesting the presence of other physical mechanisms. We hypothesize that the acoustic field generated by cell vibrations can have a role in the initial recognition between distant clusters. Integrating our findings with a suitable wave propagation model, we show that mechanical waves produced by cellular activity have sufficient energy to trigger mechanotransduction in target cells hundreds of microns away. This interaction can explain the observed distance-dependent patterns of cellular migration and motion alteration. Our results suggest that acoustic fields generated by cells can mediate cell-cell interaction and contribute to signaling and communication.https://www.frontiersin.org/articles/10.3389/fnsys.2025.1484769/fullcell-cell interactionsnanomotion sensormechanical wavesacoustic fieldneuroblastoma cellcell behavior |
| spellingShingle | Marco Girasole Pier Francesco Moretti Angela Di Giannatale Virginia Di Paolo Angela Galardi Silvia Lampis Simone Dinarelli Giovanni Longo Toward a role for the acoustic field in cells interaction Frontiers in Systems Neuroscience cell-cell interactions nanomotion sensor mechanical waves acoustic field neuroblastoma cell cell behavior |
| title | Toward a role for the acoustic field in cells interaction |
| title_full | Toward a role for the acoustic field in cells interaction |
| title_fullStr | Toward a role for the acoustic field in cells interaction |
| title_full_unstemmed | Toward a role for the acoustic field in cells interaction |
| title_short | Toward a role for the acoustic field in cells interaction |
| title_sort | toward a role for the acoustic field in cells interaction |
| topic | cell-cell interactions nanomotion sensor mechanical waves acoustic field neuroblastoma cell cell behavior |
| url | https://www.frontiersin.org/articles/10.3389/fnsys.2025.1484769/full |
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