Single-cell immunopathology of recurrent acute generalized exanthematous pustulosis associated with vancomycin

Single-cell immunopathology of recurrent acute generalized exanthematous pustulosis associated with vancomycin

Background: Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction to medication that presents within 72 hours of exposure with erythematous papules and plaques with overlying pustules. The immunopathogenesis and predisposing factors of AGEP are not well characteriz...

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Main Authors: Eric M. Mukherjee, MD, PhD, Andrew Gibson, PhD, Matthew S. Krantz, MD, Rama Gangula, MS, Amy M. Palubinsky, PhD, Alan S. Boyd, MD, Jeffrey P. Zwerner, MD, PhD, Anna K. Dewan, MD, MS, Nontaya Nakkam, PhD, Katherine C. Konvinse, MD, PhD, Yueran Li, PhD, Ramesh Ram, PhD, Abha Chopra, PhD, Elizabeth J. Phillips, MD
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Journal of Allergy and Clinical Immunology: Global
Subjects:
Acute generalized exanthematous pustulosis
vancomycin
drug reaction analysis
multiomic analysis
T-cell response
Online Access:http://www.sciencedirect.com/science/article/pii/S277282932500027X
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