Association between urinary selenium level and early menopause in Zhuang women in Guangxi based on cross-sectional analysis
Objective To analyze the association between urinary selenium (Se) level and early menopause (EM) in Zhuang women in Guangxi, and to provide evidence for preventing the occurrence of EM. Methods Based on the baseline data of the"Prospective Cohort Study of Chronic Diseases in Guangxi Natural Mi...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Guangxi Medical University
2025-04-01
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| Series: | Guangxi Yike Daxue xuebao |
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| Online Access: | https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2025.02.017 |
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| author | LU Peini XU Xuemei WEI Gangjie HUANG Xuanqian SU Li HUANG Dongping ZENG Xiaoyun QIU Xiaoqiang LIU Shun |
| author_facet | LU Peini XU Xuemei WEI Gangjie HUANG Xuanqian SU Li HUANG Dongping ZENG Xiaoyun QIU Xiaoqiang LIU Shun |
| author_sort | LU Peini |
| collection | DOAJ |
| description | Objective To analyze the association between urinary selenium (Se) level and early menopause (EM) in Zhuang women in Guangxi, and to provide evidence for preventing the occurrence of EM. Methods Based on the baseline data of the"Prospective Cohort Study of Chronic Diseases in Guangxi Natural Minority Population", inductively coupled plasma mass spectrometry (ICP-MS) was used to detect the concentration of selenium in urine. According to the self-reported age at menopause, participants were divided into EM group and non-EM group. The association between urinary Se level and EM was analyzed by logistic regression model, and the trend test was used to evaluate the dose-response relationship between urinary Se concentration and EM. Results A total of 2, 394 participants were included in the study, with 155 in the EM group and 2, 239 in the non-EM group. No association was found between urinary Se levels and EM in all subjects (OR=0.98, 95% CI: 0.73-1.31). However, when the participants were restricted to under 55 years old of age, urinary Se concentration was found to be positively associated with the risk of EM occurrence (OR=1.82, 95% CI: 1.10-3.01), and urinary Se concentration in the fourth quantile significantly increased the risk of EM occurrence compared to that in the first quantile (OR=2.61, 95% CI: 1.19-5.68). After propensity score matching, urinary Se concentration in the fourth quantile still significantly increased the risk of EM occurrence (OR=8.29, 95% CI: 1.40-49.01). The trend test was statistically significant (P < 0.05). Conclusion Elevated urinary Se concentration may increase the risk of EM in women. |
| format | Article |
| id | doaj-art-229957ff8bf344cfb26a77ac6c4ec90c |
| institution | Kabale University |
| issn | 1005-930X |
| language | zho |
| publishDate | 2025-04-01 |
| publisher | Editorial Office of Journal of Guangxi Medical University |
| record_format | Article |
| series | Guangxi Yike Daxue xuebao |
| spelling | doaj-art-229957ff8bf344cfb26a77ac6c4ec90c2025-08-20T03:52:48ZzhoEditorial Office of Journal of Guangxi Medical UniversityGuangxi Yike Daxue xuebao1005-930X2025-04-0142228929510.16190/j.cnki.45-1211/r.2025.02.017gxykdxxb-42-2-289Association between urinary selenium level and early menopause in Zhuang women in Guangxi based on cross-sectional analysisLU Peini0XU Xuemei1WEI Gangjie2HUANG Xuanqian3SU Li4HUANG Dongping5ZENG Xiaoyun6QIU Xiaoqiang7LIU Shun8Department of Epidemiology, School of Public Health, Guangxi Medical University, Nanning 530021, ChinaDepartment of Epidemiology, School of Public Health, Guangxi Medical University, Nanning 530021, ChinaDepartment of Epidemiology, School of Public Health, Guangxi Medical University, Nanning 530021, ChinaDepartment of Epidemiology, School of Public Health, Guangxi Medical University, Nanning 530021, ChinaDepartment of Epidemiology, School of Public Health, Guangxi Medical University, Nanning 530021, ChinaDepartment of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning 530021, ChinaDepartment of Epidemiology, School of Public Health, Guangxi Medical University, Nanning 530021, ChinaDepartment of Epidemiology, School of Public Health, Guangxi Medical University, Nanning 530021, ChinaDepartment of Maternal, Child and Adolescent Health, School of Public Health, Guangxi Medical University, Nanning 530021, ChinaObjective To analyze the association between urinary selenium (Se) level and early menopause (EM) in Zhuang women in Guangxi, and to provide evidence for preventing the occurrence of EM. Methods Based on the baseline data of the"Prospective Cohort Study of Chronic Diseases in Guangxi Natural Minority Population", inductively coupled plasma mass spectrometry (ICP-MS) was used to detect the concentration of selenium in urine. According to the self-reported age at menopause, participants were divided into EM group and non-EM group. The association between urinary Se level and EM was analyzed by logistic regression model, and the trend test was used to evaluate the dose-response relationship between urinary Se concentration and EM. Results A total of 2, 394 participants were included in the study, with 155 in the EM group and 2, 239 in the non-EM group. No association was found between urinary Se levels and EM in all subjects (OR=0.98, 95% CI: 0.73-1.31). However, when the participants were restricted to under 55 years old of age, urinary Se concentration was found to be positively associated with the risk of EM occurrence (OR=1.82, 95% CI: 1.10-3.01), and urinary Se concentration in the fourth quantile significantly increased the risk of EM occurrence compared to that in the first quantile (OR=2.61, 95% CI: 1.19-5.68). After propensity score matching, urinary Se concentration in the fourth quantile still significantly increased the risk of EM occurrence (OR=8.29, 95% CI: 1.40-49.01). The trend test was statistically significant (P < 0.05). Conclusion Elevated urinary Se concentration may increase the risk of EM in women.https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2025.02.017zhuang ethnic groupurinary seleniumearly menopause |
| spellingShingle | LU Peini XU Xuemei WEI Gangjie HUANG Xuanqian SU Li HUANG Dongping ZENG Xiaoyun QIU Xiaoqiang LIU Shun Association between urinary selenium level and early menopause in Zhuang women in Guangxi based on cross-sectional analysis Guangxi Yike Daxue xuebao zhuang ethnic group urinary selenium early menopause |
| title | Association between urinary selenium level and early menopause in Zhuang women in Guangxi based on cross-sectional analysis |
| title_full | Association between urinary selenium level and early menopause in Zhuang women in Guangxi based on cross-sectional analysis |
| title_fullStr | Association between urinary selenium level and early menopause in Zhuang women in Guangxi based on cross-sectional analysis |
| title_full_unstemmed | Association between urinary selenium level and early menopause in Zhuang women in Guangxi based on cross-sectional analysis |
| title_short | Association between urinary selenium level and early menopause in Zhuang women in Guangxi based on cross-sectional analysis |
| title_sort | association between urinary selenium level and early menopause in zhuang women in guangxi based on cross sectional analysis |
| topic | zhuang ethnic group urinary selenium early menopause |
| url | https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2025.02.017 |
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