Radiosensitization of the Gold, Silver, and Gadolinium Nanoparticles in 177Lu Radionuclide Radiation Field in Microscopic and Macroscopic Scales in the Liver Radionuclide Therapy
Purpose: The purpose of this study was to estimate the dose enhancement of Gold, Silver, and Gadolinium on both microscopic and macroscopic scales in liver 177Lu nano-radionuclide therapy. Materials and Methods: The 177Lu radionuclide at the nano-scale was simulated using the MCNP 6.1 Monte Carl...
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Tehran University of Medical Sciences
2025-07-01
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| Series: | Frontiers in Biomedical Technologies |
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| Online Access: | https://fbt.tums.ac.ir/index.php/fbt/article/view/935 |
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| author | Wrya Parwaie Mikaeil Molazadeh Tohid Mortezazadeh Hosein Ghiasi |
| author_facet | Wrya Parwaie Mikaeil Molazadeh Tohid Mortezazadeh Hosein Ghiasi |
| author_sort | Wrya Parwaie |
| collection | DOAJ |
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Purpose: The purpose of this study was to estimate the dose enhancement of Gold, Silver, and Gadolinium on both microscopic and macroscopic scales in liver 177Lu nano-radionuclide therapy.
Materials and Methods: The 177Lu radionuclide at the nano-scale was simulated using the MCNP 6.1 Monte Carlo (MC) simulation method. The emitted radiation characteristics, such as type and energy of emitted radiation, were modeled at the center of the tumor. The tumor cell (phantom liver) was filled with cubic voxels with sides of 1µm. These cubic voxels were then filled with GNP, AgNP, and GdNP spherical nanoparticles with a diameter of 30 nm each, and in a concentration of 10 mg/g of tissue.
Results: The DEF was estimated at 5µm, 20µm, 50µm, 70µm, and 100µm from a single 177Lu nano-radionuclide radiation source at the center of the phantom liver cell, emitting both γ-ray and β- particles. A significant γ-ray DEF of up to 89% was observed at some µm around the source. Additionally, high DEF was derived for β- rays at some µm around the simulated radionuclides compared to greater distances. Estimated DEF in tumoral tissue including GNP was 89%, 78%, 72%, 47%, and 25% at 5µm, 20µm, 50µm, 70µm, and 100µm respectively from the center. DEF for the other nanoparticles was also derived.
Conclusion: A dramatic DEF was observed in the close vicinity of NPs around 177Lu as the radiation source, possibly due to the great gradient in dose and dominance of the photo-electric phenomenon.
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| format | Article |
| id | doaj-art-2298aee4d0174131a0b3af78c7e5f671 |
| institution | Kabale University |
| issn | 2345-5837 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Frontiers in Biomedical Technologies |
| spelling | doaj-art-2298aee4d0174131a0b3af78c7e5f6712025-08-20T04:02:32ZengTehran University of Medical SciencesFrontiers in Biomedical Technologies2345-58372025-07-0112310.18502/fbt.v12i3.19173Radiosensitization of the Gold, Silver, and Gadolinium Nanoparticles in 177Lu Radionuclide Radiation Field in Microscopic and Macroscopic Scales in the Liver Radionuclide TherapyWrya Parwaie0Mikaeil Molazadeh1Tohid Mortezazadeh2Hosein Ghiasi3Department of Medical Physics, Faculty of Paramedical Sciences, Ilam University of Medical Sciences, Ilam, IranDepartment of Medical Physics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Medical Physics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IranMedical Radiation Research Team, Tabriz University of Medical Sciences. Tabriz. Iran. Purpose: The purpose of this study was to estimate the dose enhancement of Gold, Silver, and Gadolinium on both microscopic and macroscopic scales in liver 177Lu nano-radionuclide therapy. Materials and Methods: The 177Lu radionuclide at the nano-scale was simulated using the MCNP 6.1 Monte Carlo (MC) simulation method. The emitted radiation characteristics, such as type and energy of emitted radiation, were modeled at the center of the tumor. The tumor cell (phantom liver) was filled with cubic voxels with sides of 1µm. These cubic voxels were then filled with GNP, AgNP, and GdNP spherical nanoparticles with a diameter of 30 nm each, and in a concentration of 10 mg/g of tissue. Results: The DEF was estimated at 5µm, 20µm, 50µm, 70µm, and 100µm from a single 177Lu nano-radionuclide radiation source at the center of the phantom liver cell, emitting both γ-ray and β- particles. A significant γ-ray DEF of up to 89% was observed at some µm around the source. Additionally, high DEF was derived for β- rays at some µm around the simulated radionuclides compared to greater distances. Estimated DEF in tumoral tissue including GNP was 89%, 78%, 72%, 47%, and 25% at 5µm, 20µm, 50µm, 70µm, and 100µm respectively from the center. DEF for the other nanoparticles was also derived. Conclusion: A dramatic DEF was observed in the close vicinity of NPs around 177Lu as the radiation source, possibly due to the great gradient in dose and dominance of the photo-electric phenomenon. https://fbt.tums.ac.ir/index.php/fbt/article/view/935Monte CarloRadionuclideDose EnhancementNanoparticle |
| spellingShingle | Wrya Parwaie Mikaeil Molazadeh Tohid Mortezazadeh Hosein Ghiasi Radiosensitization of the Gold, Silver, and Gadolinium Nanoparticles in 177Lu Radionuclide Radiation Field in Microscopic and Macroscopic Scales in the Liver Radionuclide Therapy Frontiers in Biomedical Technologies Monte Carlo Radionuclide Dose Enhancement Nanoparticle |
| title | Radiosensitization of the Gold, Silver, and Gadolinium Nanoparticles in 177Lu Radionuclide Radiation Field in Microscopic and Macroscopic Scales in the Liver Radionuclide Therapy |
| title_full | Radiosensitization of the Gold, Silver, and Gadolinium Nanoparticles in 177Lu Radionuclide Radiation Field in Microscopic and Macroscopic Scales in the Liver Radionuclide Therapy |
| title_fullStr | Radiosensitization of the Gold, Silver, and Gadolinium Nanoparticles in 177Lu Radionuclide Radiation Field in Microscopic and Macroscopic Scales in the Liver Radionuclide Therapy |
| title_full_unstemmed | Radiosensitization of the Gold, Silver, and Gadolinium Nanoparticles in 177Lu Radionuclide Radiation Field in Microscopic and Macroscopic Scales in the Liver Radionuclide Therapy |
| title_short | Radiosensitization of the Gold, Silver, and Gadolinium Nanoparticles in 177Lu Radionuclide Radiation Field in Microscopic and Macroscopic Scales in the Liver Radionuclide Therapy |
| title_sort | radiosensitization of the gold silver and gadolinium nanoparticles in 177lu radionuclide radiation field in microscopic and macroscopic scales in the liver radionuclide therapy |
| topic | Monte Carlo Radionuclide Dose Enhancement Nanoparticle |
| url | https://fbt.tums.ac.ir/index.php/fbt/article/view/935 |
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