Antimicrobial Resistance and Novel Alternative Approaches to Conventional Antibiotics
Antimicrobial resistance is a significant public health issue. The unprecedented spread of antimicrobial-resistant organisms has been identified by the World Health Organization as one of the leading healthcare threats. Projections for annual worldwide deaths attributed to antimicrobial resistance a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-07-01
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| Series: | Bacteria |
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| Online Access: | https://www.mdpi.com/2674-1334/3/3/12 |
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| _version_ | 1850258409454043136 |
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| author | Irene Berger Zvi G. Loewy |
| author_facet | Irene Berger Zvi G. Loewy |
| author_sort | Irene Berger |
| collection | DOAJ |
| description | Antimicrobial resistance is a significant public health issue. The unprecedented spread of antimicrobial-resistant organisms has been identified by the World Health Organization as one of the leading healthcare threats. Projections for annual worldwide deaths attributed to antimicrobial resistance approach 10 million by 2050, with an associated economic burden of USD 100 trillion. This paper reviews the mechanisms known to contribute to antimicrobial resistance and provides insight into potential available alternatives to conventional antibiotics. Antimicrobial approaches addressed include dual antibiotic therapy, antimicrobial peptides, monoclonal antibodies, bacteriophages, probiotics, nanomaterials, and cannabinoids. Key pathogens in need of antimicrobials referred to as the ESKAPE pathogens are discussed. |
| format | Article |
| id | doaj-art-22973b8fea84478ca16a21b2efbcf6c3 |
| institution | OA Journals |
| issn | 2674-1334 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bacteria |
| spelling | doaj-art-22973b8fea84478ca16a21b2efbcf6c32025-08-20T01:56:10ZengMDPI AGBacteria2674-13342024-07-013317118210.3390/bacteria3030012Antimicrobial Resistance and Novel Alternative Approaches to Conventional AntibioticsIrene Berger0Zvi G. Loewy1Touro College of Pharmacy, Touro University, New York, NY 10036, USATouro College of Pharmacy, Touro University, New York, NY 10036, USAAntimicrobial resistance is a significant public health issue. The unprecedented spread of antimicrobial-resistant organisms has been identified by the World Health Organization as one of the leading healthcare threats. Projections for annual worldwide deaths attributed to antimicrobial resistance approach 10 million by 2050, with an associated economic burden of USD 100 trillion. This paper reviews the mechanisms known to contribute to antimicrobial resistance and provides insight into potential available alternatives to conventional antibiotics. Antimicrobial approaches addressed include dual antibiotic therapy, antimicrobial peptides, monoclonal antibodies, bacteriophages, probiotics, nanomaterials, and cannabinoids. Key pathogens in need of antimicrobials referred to as the ESKAPE pathogens are discussed.https://www.mdpi.com/2674-1334/3/3/12ntibioticsresistancepeptidebacteriophageprobioticsnanoparticles |
| spellingShingle | Irene Berger Zvi G. Loewy Antimicrobial Resistance and Novel Alternative Approaches to Conventional Antibiotics Bacteria ntibiotics resistance peptide bacteriophage probiotics nanoparticles |
| title | Antimicrobial Resistance and Novel Alternative Approaches to Conventional Antibiotics |
| title_full | Antimicrobial Resistance and Novel Alternative Approaches to Conventional Antibiotics |
| title_fullStr | Antimicrobial Resistance and Novel Alternative Approaches to Conventional Antibiotics |
| title_full_unstemmed | Antimicrobial Resistance and Novel Alternative Approaches to Conventional Antibiotics |
| title_short | Antimicrobial Resistance and Novel Alternative Approaches to Conventional Antibiotics |
| title_sort | antimicrobial resistance and novel alternative approaches to conventional antibiotics |
| topic | ntibiotics resistance peptide bacteriophage probiotics nanoparticles |
| url | https://www.mdpi.com/2674-1334/3/3/12 |
| work_keys_str_mv | AT ireneberger antimicrobialresistanceandnovelalternativeapproachestoconventionalantibiotics AT zvigloewy antimicrobialresistanceandnovelalternativeapproachestoconventionalantibiotics |