The Effect of Adipose-Derived Stem Cells on Wound Healing: Comparison of Methods of Application
Impaired wound healing is a significant medical problem. Recently, cell-based therapy focused on stem cells has been developed to overcome the challenges of defective wound healing. In this study, we aimed to evaluate the effectiveness of adipose-derived stem cells (ASCs) in promoting wound healing,...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2019/2745640 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849307274386866176 |
|---|---|
| author | Hyeonwoo Kim Mi Ri Hyun Sang Wha Kim |
| author_facet | Hyeonwoo Kim Mi Ri Hyun Sang Wha Kim |
| author_sort | Hyeonwoo Kim |
| collection | DOAJ |
| description | Impaired wound healing is a significant medical problem. Recently, cell-based therapy focused on stem cells has been developed to overcome the challenges of defective wound healing. In this study, we aimed to evaluate the effectiveness of adipose-derived stem cells (ASCs) in promoting wound healing, using different techniques for administering them. Dorsal full-thickness skin defects (1×1 cm) were created in three groups of mice that received intravenous ASCs by intravenous injection, intramuscular injection, and topical application, respectively. Three control groups received saline in the same ways. Wound healing was assessed clinically, wounds were examined histologically, and GFP-labelled ASCs were detected with an IVIS imaging system. The results revealed that ASCs accelerated wound healing independent of their mode of administration. Histological examination showed that the ASCs accelerated reepithelialization, and IVIS analysis indicated that many ASCs were present in the wound area and disappeared after wound healing. |
| format | Article |
| id | doaj-art-2291a69defd642b48b1196f0a67c09df |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-2291a69defd642b48b1196f0a67c09df2025-08-20T03:54:48ZengWileyStem Cells International1687-966X1687-96782019-01-01201910.1155/2019/27456402745640The Effect of Adipose-Derived Stem Cells on Wound Healing: Comparison of Methods of ApplicationHyeonwoo Kim0Mi Ri Hyun1Sang Wha Kim2Department of Plastic and Reconstructive Surgery, Seoul National University Hospital, Seoul, Republic of KoreaDepartment of Plastic and Reconstructive Surgery, Seoul National University Hospital, Seoul, Republic of KoreaDepartment of Plastic and Reconstructive Surgery, Seoul National University Hospital, Seoul, Republic of KoreaImpaired wound healing is a significant medical problem. Recently, cell-based therapy focused on stem cells has been developed to overcome the challenges of defective wound healing. In this study, we aimed to evaluate the effectiveness of adipose-derived stem cells (ASCs) in promoting wound healing, using different techniques for administering them. Dorsal full-thickness skin defects (1×1 cm) were created in three groups of mice that received intravenous ASCs by intravenous injection, intramuscular injection, and topical application, respectively. Three control groups received saline in the same ways. Wound healing was assessed clinically, wounds were examined histologically, and GFP-labelled ASCs were detected with an IVIS imaging system. The results revealed that ASCs accelerated wound healing independent of their mode of administration. Histological examination showed that the ASCs accelerated reepithelialization, and IVIS analysis indicated that many ASCs were present in the wound area and disappeared after wound healing.http://dx.doi.org/10.1155/2019/2745640 |
| spellingShingle | Hyeonwoo Kim Mi Ri Hyun Sang Wha Kim The Effect of Adipose-Derived Stem Cells on Wound Healing: Comparison of Methods of Application Stem Cells International |
| title | The Effect of Adipose-Derived Stem Cells on Wound Healing: Comparison of Methods of Application |
| title_full | The Effect of Adipose-Derived Stem Cells on Wound Healing: Comparison of Methods of Application |
| title_fullStr | The Effect of Adipose-Derived Stem Cells on Wound Healing: Comparison of Methods of Application |
| title_full_unstemmed | The Effect of Adipose-Derived Stem Cells on Wound Healing: Comparison of Methods of Application |
| title_short | The Effect of Adipose-Derived Stem Cells on Wound Healing: Comparison of Methods of Application |
| title_sort | effect of adipose derived stem cells on wound healing comparison of methods of application |
| url | http://dx.doi.org/10.1155/2019/2745640 |
| work_keys_str_mv | AT hyeonwookim theeffectofadiposederivedstemcellsonwoundhealingcomparisonofmethodsofapplication AT mirihyun theeffectofadiposederivedstemcellsonwoundhealingcomparisonofmethodsofapplication AT sangwhakim theeffectofadiposederivedstemcellsonwoundhealingcomparisonofmethodsofapplication AT hyeonwookim effectofadiposederivedstemcellsonwoundhealingcomparisonofmethodsofapplication AT mirihyun effectofadiposederivedstemcellsonwoundhealingcomparisonofmethodsofapplication AT sangwhakim effectofadiposederivedstemcellsonwoundhealingcomparisonofmethodsofapplication |