A longitudinal cohort study uncovers plasma protein biomarkers predating clinical onset and treatment response of rheumatoid arthritis

A longitudinal cohort study uncovers plasma protein biomarkers predating clinical onset and treatment response of rheumatoid arthritis

Abstract Rheumatoid arthritis (RA) is a systemic inflammatory condition posing challenges in identifying biomarkers for onset, severity and treatment responses. Here we investigate the plasma proteome in a longitudinal cohort of 278 RA patients, alongside 60 at-risk individuals and 99 healthy contro...

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Main Authors: Siyu He, Chenxi Zhu, Yi Liu, Zhiqiang Xu, Rui Sun, Bin Yang, Xin Guo, Martin Herrmann i, Luis E. Muñoz, Inger Gjertsson, Rikard Holmdahl, Lunzhi Dai, Yi Zhao
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62032-1
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