Longitudinal association between hemoglobin and lung function with insights into the incidence of airflow obstruction: an observational study
Abstract Background/Aims Evidence regarding the long-term association between hemoglobin (Hb) levels and lung function in individuals from the general population is scarce. This study aimed to determine the longitudinal association between Hb levels and lung function in a community-based population...
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BMC
2025-01-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-025-03505-3 |
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| author | Jihoon Kim Yun Tae Kim Ah Young Leem Ji Ye Jung Young Sam Kim Youngmok Park |
| author_facet | Jihoon Kim Yun Tae Kim Ah Young Leem Ji Ye Jung Young Sam Kim Youngmok Park |
| author_sort | Jihoon Kim |
| collection | DOAJ |
| description | Abstract Background/Aims Evidence regarding the long-term association between hemoglobin (Hb) levels and lung function in individuals from the general population is scarce. This study aimed to determine the longitudinal association between Hb levels and lung function in a community-based population cohort in South Korea. Methods We used linear mixed regression analysis to evaluate the longitudinal associations between Hb levels and lung function parameters, including forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), and FEV1/FVC. Additionally, we used a generalized estimating equation to calculate the odds ratio (OR) of airflow obstruction (AO) according to the Hb level. Results Over an 8-year biennial follow-up of 4,468 individuals (median age, 53.9 years; men, 49.0%), we observed that in men, Hb levels were positively associated with lung function (estimated values of FVC: 16.7 mL, FEV1: 15.5 mL, FEV1/FVC: 0.18%; all P < 0.001) and a decreased incidence of AO (OR = 0.83, P < 0.001). In women, Hb levels were positively associated with FVC but not with FEV1 or FEV1/FVC (estimated values of FVC: 4.7 mL, P = 0.045; FEV1: 3.1 mL, P = 0.142; FEV1/FVC: 0.01%, P = 0.838). The incidence of AO was not significantly different among women (OR = 0.93, P = 0.568). In postmenopausal women, higher Hb levels were associated with increased lung function (estimated values of FVC: 11.8 mL, P < 0.001; FEV1: 9.8 mL, P < 0.001; FEV1/FVC: 0.09%, P = 0.052), but the incidence of AO was not statistically significant (OR = 0.82, P = 0.129). Conclusions A decreased Hb level was associated with reduced lung function and an increased incidence of AO in men. |
| format | Article |
| id | doaj-art-2289882aa06d464aa57e84d29123f25d |
| institution | Kabale University |
| issn | 1471-2466 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj-art-2289882aa06d464aa57e84d29123f25d2025-02-02T12:06:41ZengBMCBMC Pulmonary Medicine1471-24662025-01-012511910.1186/s12890-025-03505-3Longitudinal association between hemoglobin and lung function with insights into the incidence of airflow obstruction: an observational studyJihoon Kim0Yun Tae Kim1Ah Young Leem2Ji Ye Jung3Young Sam Kim4Youngmok Park5Department of Internal Medicine, Severance Hospital, Yonsei University College of MedicineDivision of Biostatistics, Kangbuk Samsung HospitalDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of MedicineDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of MedicineDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of MedicineDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of MedicineAbstract Background/Aims Evidence regarding the long-term association between hemoglobin (Hb) levels and lung function in individuals from the general population is scarce. This study aimed to determine the longitudinal association between Hb levels and lung function in a community-based population cohort in South Korea. Methods We used linear mixed regression analysis to evaluate the longitudinal associations between Hb levels and lung function parameters, including forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), and FEV1/FVC. Additionally, we used a generalized estimating equation to calculate the odds ratio (OR) of airflow obstruction (AO) according to the Hb level. Results Over an 8-year biennial follow-up of 4,468 individuals (median age, 53.9 years; men, 49.0%), we observed that in men, Hb levels were positively associated with lung function (estimated values of FVC: 16.7 mL, FEV1: 15.5 mL, FEV1/FVC: 0.18%; all P < 0.001) and a decreased incidence of AO (OR = 0.83, P < 0.001). In women, Hb levels were positively associated with FVC but not with FEV1 or FEV1/FVC (estimated values of FVC: 4.7 mL, P = 0.045; FEV1: 3.1 mL, P = 0.142; FEV1/FVC: 0.01%, P = 0.838). The incidence of AO was not significantly different among women (OR = 0.93, P = 0.568). In postmenopausal women, higher Hb levels were associated with increased lung function (estimated values of FVC: 11.8 mL, P < 0.001; FEV1: 9.8 mL, P < 0.001; FEV1/FVC: 0.09%, P = 0.052), but the incidence of AO was not statistically significant (OR = 0.82, P = 0.129). Conclusions A decreased Hb level was associated with reduced lung function and an increased incidence of AO in men.https://doi.org/10.1186/s12890-025-03505-3Airflow obstructionHemoglobinSpirometry |
| spellingShingle | Jihoon Kim Yun Tae Kim Ah Young Leem Ji Ye Jung Young Sam Kim Youngmok Park Longitudinal association between hemoglobin and lung function with insights into the incidence of airflow obstruction: an observational study BMC Pulmonary Medicine Airflow obstruction Hemoglobin Spirometry |
| title | Longitudinal association between hemoglobin and lung function with insights into the incidence of airflow obstruction: an observational study |
| title_full | Longitudinal association between hemoglobin and lung function with insights into the incidence of airflow obstruction: an observational study |
| title_fullStr | Longitudinal association between hemoglobin and lung function with insights into the incidence of airflow obstruction: an observational study |
| title_full_unstemmed | Longitudinal association between hemoglobin and lung function with insights into the incidence of airflow obstruction: an observational study |
| title_short | Longitudinal association between hemoglobin and lung function with insights into the incidence of airflow obstruction: an observational study |
| title_sort | longitudinal association between hemoglobin and lung function with insights into the incidence of airflow obstruction an observational study |
| topic | Airflow obstruction Hemoglobin Spirometry |
| url | https://doi.org/10.1186/s12890-025-03505-3 |
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