Comparison of salivary beta-defensin-1 levels in patients with periodontitis before and after phase I periodontal therapy
Background. This study compared human β-defensin 1 (hBD-1) salivary levels in patients with periodontitis before and after phase I periodontal therapy. Methods. This controlled before-and-after study included 16 patients in the intervention group and 28 participants in the control group. Patients in...
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| Language: | English |
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Tabriz University of Medical Sciences
2024-05-01
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| Series: | Journal of Advanced Periodontology and Implant Dentistry |
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| Online Access: | https://japid.tbzmed.ac.ir/PDF/japid-16-30.pdf |
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| author | Somaye Ansari Moghadam Sina Pishadast Leila Gholami Ebrahim Alijani Alireza Ansari Moghadam Mahdi Hadilou |
| author_facet | Somaye Ansari Moghadam Sina Pishadast Leila Gholami Ebrahim Alijani Alireza Ansari Moghadam Mahdi Hadilou |
| author_sort | Somaye Ansari Moghadam |
| collection | DOAJ |
| description | Background. This study compared human β-defensin 1 (hBD-1) salivary levels in patients with periodontitis before and after phase I periodontal therapy. Methods. This controlled before-and-after study included 16 patients in the intervention group and 28 participants in the control group. Patients in the intervention group had stage 3 grade B periodontitis with no systemic diseases and had not taken any medications in the last six months. The control group included participants with healthy periodontium. Before and after phase I periodontal therapy, salivary samples were collected from the intervention group. ELISA was used to measure hBD-1 levels. Results. Salivary levels of hBD-1 decreased after phase I periodontal treatment in periodontitis patients, approaching those in healthy individuals. However, this reduction was not statistically significant (P=0.389). In patients with a probing depth (PD) of at least 3 mm, salivary levels of hBD-1 decreased significantly (P=0.019) following the intervention. There was no significant correlation between changes in hBD-1 levels and clinical indices, such as clinical attachment loss (CAL), probing depth, or bleeding index (BI) (P˃0.05). Conclusion. The current study demonstrated promising results concerning a probable link between hBD-1 and periodontitis. However, more research with sufficiently large sample sizes and more robust study designs is necessary. |
| format | Article |
| id | doaj-art-22896b61a9c44ae194e8faa87f14e421 |
| institution | DOAJ |
| issn | 2645-5390 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Journal of Advanced Periodontology and Implant Dentistry |
| spelling | doaj-art-22896b61a9c44ae194e8faa87f14e4212025-08-20T02:50:00ZengTabriz University of Medical SciencesJournal of Advanced Periodontology and Implant Dentistry2645-53902024-05-01161303510.34172/japid.2024.002japid-2293Comparison of salivary beta-defensin-1 levels in patients with periodontitis before and after phase I periodontal therapySomaye Ansari Moghadam0Sina Pishadast1Leila Gholami2Ebrahim Alijani3Alireza Ansari Moghadam4Mahdi Hadilou5Department of Periodontology, Oral and Dental Disease Research Center, Zahedan University of Medical Sciences, Zahedan, IranOral and Dental Disease Research Center, Zahedan University of Medical Sciences, Zahedan, IranDepartment of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, CanadaDepartment of Clinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, IranDepartment of Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, IranFaculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, IranBackground. This study compared human β-defensin 1 (hBD-1) salivary levels in patients with periodontitis before and after phase I periodontal therapy. Methods. This controlled before-and-after study included 16 patients in the intervention group and 28 participants in the control group. Patients in the intervention group had stage 3 grade B periodontitis with no systemic diseases and had not taken any medications in the last six months. The control group included participants with healthy periodontium. Before and after phase I periodontal therapy, salivary samples were collected from the intervention group. ELISA was used to measure hBD-1 levels. Results. Salivary levels of hBD-1 decreased after phase I periodontal treatment in periodontitis patients, approaching those in healthy individuals. However, this reduction was not statistically significant (P=0.389). In patients with a probing depth (PD) of at least 3 mm, salivary levels of hBD-1 decreased significantly (P=0.019) following the intervention. There was no significant correlation between changes in hBD-1 levels and clinical indices, such as clinical attachment loss (CAL), probing depth, or bleeding index (BI) (P˃0.05). Conclusion. The current study demonstrated promising results concerning a probable link between hBD-1 and periodontitis. However, more research with sufficiently large sample sizes and more robust study designs is necessary.https://japid.tbzmed.ac.ir/PDF/japid-16-30.pdfbeta-defensinschronic periodontitisenzyme-linked immunosorbent assayroot planing |
| spellingShingle | Somaye Ansari Moghadam Sina Pishadast Leila Gholami Ebrahim Alijani Alireza Ansari Moghadam Mahdi Hadilou Comparison of salivary beta-defensin-1 levels in patients with periodontitis before and after phase I periodontal therapy Journal of Advanced Periodontology and Implant Dentistry beta-defensins chronic periodontitis enzyme-linked immunosorbent assay root planing |
| title | Comparison of salivary beta-defensin-1 levels in patients with periodontitis before and after phase I periodontal therapy |
| title_full | Comparison of salivary beta-defensin-1 levels in patients with periodontitis before and after phase I periodontal therapy |
| title_fullStr | Comparison of salivary beta-defensin-1 levels in patients with periodontitis before and after phase I periodontal therapy |
| title_full_unstemmed | Comparison of salivary beta-defensin-1 levels in patients with periodontitis before and after phase I periodontal therapy |
| title_short | Comparison of salivary beta-defensin-1 levels in patients with periodontitis before and after phase I periodontal therapy |
| title_sort | comparison of salivary beta defensin 1 levels in patients with periodontitis before and after phase i periodontal therapy |
| topic | beta-defensins chronic periodontitis enzyme-linked immunosorbent assay root planing |
| url | https://japid.tbzmed.ac.ir/PDF/japid-16-30.pdf |
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