Immunohistochemical Profiling of Immune Checkpoints in Chronic Hepatitis B Liver Tissue

Immunohistochemical Profiling of Immune Checkpoints in Chronic Hepatitis B Liver Tissue

Chronic hepatitis B (CHB) remains a significant global health concern due to complications like cirrhosis and liver cancer. Immune cell exhaustion, characterized by increased suppressive molecules and inhibitory receptors, represents a critical feature of CHB. Understanding the mechanisms of hepatic...

Full description

Saved in:

Bibliographic Details
Main Authors:	João Panão-Costa, Rui Caetano Oliveira, Paulo Teixeira, Francisco Caramelo, Maria Augusta Cipriano, Olga Borges, Armando Carvalho
Format:	Article
Language:	English
Published:	MDPI AG 2025-06-01
Series:	Pathogens
Subjects:	chronic hepatitis B immune checkpoint receptors immune checkpoint inhibitors immune checkpoint blockade immune exhaustion immunotherapy
Online Access:	https://www.mdpi.com/2076-0817/14/6/596
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

A landscape of checkpoint blockade resistance in cancer: underlying mechanisms and current strategies to overcome resistance
by: Ginette S. Santiago-Sánchez, et al.
Published: (2024-12-01)

Impact of cannabinoids on cancer outcomes in patients receiving immune checkpoint inhibitor immunotherapy
by: MariaLuisa Vigano, et al.
Published: (2025-03-01)

An immune activator encapsulating PD-L1 siRNA for augmented immune checkpoint blockade immunotherapy through Zn2+ overload triggered pyroptosis
by: Liming Gong, et al.
Published: (2025-06-01)

The mechanisms and clinical significance of CD8+ T cell exhaustion in anti-tumor immunity
by: Tao Zhong, et al.
Published: (2025-05-01)

Cryoablation combined with dual immune checkpoint blockade enhances antitumor efficacy in hepatocellular carcinoma model mice
by: Jun Gu, et al.
Published: (2024-12-01)

Multiple mechanisms and applications of tertiary lymphoid structures and immune checkpoint blockade
by: Zelin Li, et al.
Published: (2025-03-01)

Immunophenotypical characterization of immune checkpoint receptor expression in cynomolgus monkeys and human healthy volunteers in resting and in T-cell stimulatory conditions in vitro
by: Danielle Craig-Meyer, et al.
Published: (2025-12-01)

Reversing NK cell exhaustion: a novel strategy combining immune checkpoint blockade with drug sensitivity enhancement in the treatment of hepatocellular carcinoma
by: Yuxiang Huang, et al.
Published: (2025-01-01)

Mutation of isocitrate dehydrogenase indicates favorable outcomes in pan-cancer immune checkpoint blockade
by: Zhiyang Huang, et al.
Published: (2025-02-01)

The safety and efficacy of immune checkpoint blockade in children, adolescents, and young adults: A systematic review and meta-analysis
by: Pedro C.A. Reis, et al.
Published: (2025-06-01)

Dendritic cell effector mechanisms and tumor immune microenvironment infiltration define TLR8 modulation and PD-1 blockade
by: Daniel A. Ruiz-Torres, et al.
Published: (2024-12-01)

Post-translational modifications of immune checkpoints: unlocking new potentials in cancer immunotherapy
by: Qiongjie Hu, et al.
Published: (2025-03-01)

Immune checkpoint inhibitors for the treatment of solid tumors in HIV-infected patients: is it worth the risk?
by: E. A. Degtiareva, et al.
Published: (2023-02-01)

Overcoming immunosuppression in cancer: how ketogenic diets boost immune checkpoint blockade
by: Victoria E. Stefan, et al.
Published: (2024-11-01)

Potentiation of immune checkpoint blockade with an ITPP radiosensitizer studied with oxygen saturation measurements from photoacoustic imaging
by: Renee L. Tran, et al.
Published: (2025-07-01)

PD-L2 act as an independent immune checkpoint in colorectal cancer beyond PD-L1
by: Lvyun Zhu, et al.
Published: (2024-12-01)

Research progress of immune checkpoint inhibitors in the treatment of glioblastoma
by: JIA Xiaorong, et al.
Published: (2024-05-01)

A PD-L1/EGFR bispecific antibody combines immune checkpoint blockade and direct anti-cancer action for an enhanced anti-tumor response
by: Laura Rubio-Pérez, et al.
Published: (2023-12-01)

Cytokine profile of bronchoalveolar lavage in patients with and without checkpoint inhibitor pneumonitis
by: Michelle Ploch, et al.
Published: (2025-01-01)

Application of Immune Checkpoint Inhibitors in Cancer
by: Zhijun Chen, et al.
Published: (2025-08-01)

The growing potential of tofacitinib in immune checkpoint inhibitor-induced colitis: identifying remaining puzzle pieces
by: Raffaele Pellegrino, et al.
Published: (2024-11-01)

A Comprehensive Analysis of Epoxide Hydrolase 2 (EPHX2) in Pan‐Cancer
by: Weiquan Hu, et al.
Published: (2025-03-01)

Immune checkpoints in immune response to glioma: two sides of the same coin
by: Oxana Musatova, et al.
Published: (2025-08-01)

Hepatotoxicity induced by immune checkpoint inhibitors
by: Flaviu Muresan, et al.
Published: (2024-10-01)

The Role of LAIR1 as a Regulatory Receptor of Antitumor Immune Cell Responses and Tumor Cell Growth and Expansion
by: Alessandro Poggi, et al.
Published: (2025-06-01)

Immune Checkpoints in B Cells: Unlocking New Potentials in Cancer Treatment
by: Xiaoye Shi, et al.
Published: (2024-12-01)

Does Pre-Existing Chronic Obstructive Pulmonary Disease Increase the Risk of Checkpoint Inhibitor Pneumonitis in Advanced/Metastatic Non-Small Cell Lung Cancer Treated with Immune Checkpoint Inhibitors?
by: David Spillane, et al.
Published: (2025-04-01)

Patterns of immune-related adverse events in patients treated with immune checkpoint inhibitors: a Brazilian real-world analysis
by: Maria Paula Furtado Santos, et al.
Published: (2022-12-01)

Recent advances in novel tumor immunotherapy strategies based on regulating the tumor microenvironment and immune checkpoints
by: Hanhui Jing, et al.
Published: (2025-06-01)

Concurrent immune checkpoint blockade for enhanced cancer immunotherapy utilizing engineered hybrid nanovesicles
by: Yuxuan Liu, et al.
Published: (2024-11-01)

Immune checkpoint inhibitor-induced thyroiditis and its potential mechanisms
by: Xueqian Mao, et al.
Published: (2025-06-01)

Enhanced Prediction of Immune Checkpoint Blockade Response in Melanoma Using Ensemble Learning and a Hybrid Feature Selection Technique
by: Basant Badwy, et al.
Published: (2024-01-01)

Immune-checkpoint inhibitors for glioblastoma: what have we learned?
by: Antonio Omuro
Published: (2022-08-01)

Immune Checkpoints Mediate Tumor Immune Regulation  through Metabolic Pathways
by: Weiguang DU, et al.
Published: (2025-03-01)

Integrated multi-omics profiling reveals the role of the DNA methylation landscape in shaping biological heterogeneity and clinical behaviour of metastatic melanoma
by: Andrea Anichini, et al.
Published: (2025-07-01)

Differential distribution of immune checkpoints across molecular subtypes of colorectal cancer
by: Sofia Edin, et al.
Published: (2025-12-01)

iMLGAM: Integrated Machine Learning and Genetic Algorithm‐driven Multiomics analysis for pan‐cancer immunotherapy response prediction
by: Bicheng Ye, et al.
Published: (2025-04-01)

Sequentially Activated Smart DNA Nanospheres for Photoimmunotherapy and Immune Checkpoint Blockade
by: Yu Chen, et al.
Published: (2025-01-01)

Hidradenitis suppurativa in the setting of immune checkpoint inhibitor therapy: A case series
by: Liam M. Dalton, BA, et al.
Published: (2025-05-01)

Reprogramming the immunosuppressive tumor microenvironment results in successful clearance of tumors resistant to radiation therapy and anti-PD-1/PD-L1
by: Debayan Mukherjee, et al.
Published: (2023-12-01)