Toll-Like Receptors, Tissue Injury, and Tumourigenesis
Toll-like receptors (TLRs) belong to a class of molecules known as pattern recognition receptors, and they are part of the innate immune system, although they modulate mechanisms that impact the development of adaptive immune responses. Several studies have shown that TLRs, and their intracellular s...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2010/581837 |
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| _version_ | 1850228202069295104 |
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| author | Savvas Ioannou Michael Voulgarelis |
| author_facet | Savvas Ioannou Michael Voulgarelis |
| author_sort | Savvas Ioannou |
| collection | DOAJ |
| description | Toll-like receptors (TLRs) belong to a class of molecules known as pattern recognition receptors, and they are part of the innate immune system, although they modulate mechanisms that impact the development of adaptive immune responses. Several studies have shown that TLRs, and their intracellular signalling components, constitute an important cellular pathway mediating the inflammatory process. Moreover, their critical role in the regulation of tissue injury and wound healing process as well as in the regulation of apoptosis is well established. However, interest in the role of these receptors in cancer development and progression has been increasing over the last years. TLRs are likely candidates to mediate effects of the innate immune system within the tumour microenvironment. A rapidly expanding area of research regarding the expression and function of TLRs in cancer cells and its association with chemoresistance and tumourigenesis, and TLR-based therapy as potential immunotherapy in cancer treatment is taking place over the last years. |
| format | Article |
| id | doaj-art-2283f752376d497fbb1118aaab19a809 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-2283f752376d497fbb1118aaab19a8092025-08-20T02:04:36ZengWileyMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/581837581837Toll-Like Receptors, Tissue Injury, and TumourigenesisSavvas Ioannou0Michael Voulgarelis1Department of Pathophysiology, Medical School, National University of Athens, 75 Mikras Asias Street, 11527 Athens, GreeceDepartment of Pathophysiology, Medical School, National University of Athens, 75 Mikras Asias Street, 11527 Athens, GreeceToll-like receptors (TLRs) belong to a class of molecules known as pattern recognition receptors, and they are part of the innate immune system, although they modulate mechanisms that impact the development of adaptive immune responses. Several studies have shown that TLRs, and their intracellular signalling components, constitute an important cellular pathway mediating the inflammatory process. Moreover, their critical role in the regulation of tissue injury and wound healing process as well as in the regulation of apoptosis is well established. However, interest in the role of these receptors in cancer development and progression has been increasing over the last years. TLRs are likely candidates to mediate effects of the innate immune system within the tumour microenvironment. A rapidly expanding area of research regarding the expression and function of TLRs in cancer cells and its association with chemoresistance and tumourigenesis, and TLR-based therapy as potential immunotherapy in cancer treatment is taking place over the last years.http://dx.doi.org/10.1155/2010/581837 |
| spellingShingle | Savvas Ioannou Michael Voulgarelis Toll-Like Receptors, Tissue Injury, and Tumourigenesis Mediators of Inflammation |
| title | Toll-Like Receptors, Tissue Injury, and Tumourigenesis |
| title_full | Toll-Like Receptors, Tissue Injury, and Tumourigenesis |
| title_fullStr | Toll-Like Receptors, Tissue Injury, and Tumourigenesis |
| title_full_unstemmed | Toll-Like Receptors, Tissue Injury, and Tumourigenesis |
| title_short | Toll-Like Receptors, Tissue Injury, and Tumourigenesis |
| title_sort | toll like receptors tissue injury and tumourigenesis |
| url | http://dx.doi.org/10.1155/2010/581837 |
| work_keys_str_mv | AT savvasioannou tolllikereceptorstissueinjuryandtumourigenesis AT michaelvoulgarelis tolllikereceptorstissueinjuryandtumourigenesis |