Research advances of pericytes in renal interstitial fibrosis
Pericytes are mesenchymal cells in contact with endothelial cells and partially embedded in the basement membrane of blood vessels.Pericytes possess the capability of differentiating and their surface markers change according to different tissues，various developmental stages and diverse pathophysiol...
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| Format: | Article |
| Language: | zho |
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Editorial Department of Journal of Clinical Nephrology
2022-01-01
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| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.01.013 |
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| _version_ | 1850040052648771584 |
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| author | Feng Yi-duo Diao Zong-li Liu Wen-hu |
| author_facet | Feng Yi-duo Diao Zong-li Liu Wen-hu |
| author_sort | Feng Yi-duo |
| collection | DOAJ |
| description | Pericytes are mesenchymal cells in contact with endothelial cells and partially embedded in the basement membrane of blood vessels.Pericytes possess the capability of differentiating and their surface markers change according to different tissues，various developmental stages and diverse pathophysiological environments.Numerous studies have demonstrated that pericytes are a major source of kidney myofibroblasts and multiple signal pathways are involved in the process of pericytes/fibroblasts transdifferentiation into myofibroblasts.Pericyte-endothelial cell interaction also plays an important role in the development of renal fibrosis.This review summarized the latest advances of pericytes in the pathogenesis of renal intestitial fibrosis and targeted therapy for pericytes may be an effective anti-kidney fibrosis strategy. |
| format | Article |
| id | doaj-art-2280da221ecc4e80a8bbd56ce39a7766 |
| institution | DOAJ |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2022-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-2280da221ecc4e80a8bbd56ce39a77662025-08-20T02:56:11ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902022-01-0122677123110679Research advances of pericytes in renal interstitial fibrosisFeng Yi-duoDiao Zong-liLiu Wen-huPericytes are mesenchymal cells in contact with endothelial cells and partially embedded in the basement membrane of blood vessels.Pericytes possess the capability of differentiating and their surface markers change according to different tissues，various developmental stages and diverse pathophysiological environments.Numerous studies have demonstrated that pericytes are a major source of kidney myofibroblasts and multiple signal pathways are involved in the process of pericytes/fibroblasts transdifferentiation into myofibroblasts.Pericyte-endothelial cell interaction also plays an important role in the development of renal fibrosis.This review summarized the latest advances of pericytes in the pathogenesis of renal intestitial fibrosis and targeted therapy for pericytes may be an effective anti-kidney fibrosis strategy.http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.01.013PericytesRenal interstitial fibrosisMyofibroblastTransdifferentiation |
| spellingShingle | Feng Yi-duo Diao Zong-li Liu Wen-hu Research advances of pericytes in renal interstitial fibrosis Linchuang shenzangbing zazhi Pericytes Renal interstitial fibrosis Myofibroblast Transdifferentiation |
| title | Research advances of pericytes in renal interstitial fibrosis |
| title_full | Research advances of pericytes in renal interstitial fibrosis |
| title_fullStr | Research advances of pericytes in renal interstitial fibrosis |
| title_full_unstemmed | Research advances of pericytes in renal interstitial fibrosis |
| title_short | Research advances of pericytes in renal interstitial fibrosis |
| title_sort | research advances of pericytes in renal interstitial fibrosis |
| topic | Pericytes Renal interstitial fibrosis Myofibroblast Transdifferentiation |
| url | http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.01.013 |
| work_keys_str_mv | AT fengyiduo researchadvancesofpericytesinrenalinterstitialfibrosis AT diaozongli researchadvancesofpericytesinrenalinterstitialfibrosis AT liuwenhu researchadvancesofpericytesinrenalinterstitialfibrosis |