Evaluation of insulin-like growth factor-1 in apparently healthy infants and prepubertal Egyptian children with different nutritional statuses
Abstract Objectives to estimate insulin-like growth factor-1 (IGF-1) levels in apparently healthy infants and prepubertal children and compare results among different nutritional statuses. Methods Our cross-sectional work is a sub-study of a screening project for anemia and nutritional status. We in...
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BMC
2024-10-01
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| Series: | BMC Pediatrics |
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| Online Access: | https://doi.org/10.1186/s12887-024-05118-x |
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| author | Hanan Mina Fouad Amal Ahmed Mohamed Nashwa Adel Mohamed Abdulhay Iman Khalifa Randa Ibrahim Naglaa Elsalway Ghada Maher Thabet Karima Nasraldin Ingy Maher El-Hefny Marwa S. Abd El-raouf Dalia Ghareeb |
| author_facet | Hanan Mina Fouad Amal Ahmed Mohamed Nashwa Adel Mohamed Abdulhay Iman Khalifa Randa Ibrahim Naglaa Elsalway Ghada Maher Thabet Karima Nasraldin Ingy Maher El-Hefny Marwa S. Abd El-raouf Dalia Ghareeb |
| author_sort | Hanan Mina Fouad |
| collection | DOAJ |
| description | Abstract Objectives to estimate insulin-like growth factor-1 (IGF-1) levels in apparently healthy infants and prepubertal children and compare results among different nutritional statuses. Methods Our cross-sectional work is a sub-study of a screening project for anemia and nutritional status. We included 252 apparently healthy infants and children with a mean age of 3.7 ± 1.3 years (1.1–6.6), with equal gender distribution. Data retrieved included breastfeeding and anthropometric measures. We tested the stored blood samples for IGF-1 levels. The sample size was reached when all kits were consumed. Results abnormal anthropometric measures were detected in 32.9%, either a single or multiple, and 86.5% were breastfed. Girls had significantly higher serum IGF-1 levels than boys (P: <0.001), which was noticeable in girls with abnormal nutritional status detected with anthropometry. Breastfeeding showed no significant association with IGF-1 levels. No significant difference was observed between IGF-1 levels between children with normal versus those with abnormal growth measures. Children with overweight or obesity had significantly lower IGF-1 than children with other body mass index (BMI) categories. Serum IGF-1 levels correlated positively with arm muscle area Z scores in infants and toddlers and weight and BMI Z scores in children between three and four. Also, IGF-1 correlated positively with the triceps skinfold Z score and arm muscle area Z score between four and five. Conclusions Among studied infants and prepubertal children, serum IGF-1 was significantly higher in girls than boys and was considerably lower in children with overweight or obesity. Breastfeeding showed no association with IGF-1 levels. |
| format | Article |
| id | doaj-art-227cb43af0fc405394dade5c19c2943f |
| institution | OA Journals |
| issn | 1471-2431 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj-art-227cb43af0fc405394dade5c19c2943f2025-08-20T02:11:54ZengBMCBMC Pediatrics1471-24312024-10-012411810.1186/s12887-024-05118-xEvaluation of insulin-like growth factor-1 in apparently healthy infants and prepubertal Egyptian children with different nutritional statusesHanan Mina Fouad0Amal Ahmed Mohamed1Nashwa Adel2Mohamed Abdulhay3Iman Khalifa4Randa Ibrahim5Naglaa Elsalway6Ghada Maher Thabet7Karima Nasraldin8Ingy Maher El-Hefny9Marwa S. Abd El-raouf10Dalia Ghareeb11Pediatrics department, Faculty of Medicine, Helwan UniversityDepartment of Biochemistry & Molecular Biology, National Hepatology & Tropical Medicine Research institute, GOTHIPediatrics department, Faculty of Medicine, Helwan UniversityPediatrics department, Faculty of Medicine, Helwan UniversityPediatrics department, Faculty of Medicine, Helwan UniversityClinical and Chemical Pathology Department, National Nutrition institute GOTHIDepartment of Clinical and Chemical pathology, Faculty of Medicine, Cairo UniversityDepartment of Clinical and Chemical pathology, Faculty of Medicine, Cairo UniversityFaculty of Biotechnology, Modern Sciences and Arts UniversityFaculty of Biotechnology, Modern Sciences and Arts UniversityDepartment of Public Health, Faculty of Medicine, Benha UniversityDepartment of Clinical Pathology, Faculty of Medicine, Suez UniversityAbstract Objectives to estimate insulin-like growth factor-1 (IGF-1) levels in apparently healthy infants and prepubertal children and compare results among different nutritional statuses. Methods Our cross-sectional work is a sub-study of a screening project for anemia and nutritional status. We included 252 apparently healthy infants and children with a mean age of 3.7 ± 1.3 years (1.1–6.6), with equal gender distribution. Data retrieved included breastfeeding and anthropometric measures. We tested the stored blood samples for IGF-1 levels. The sample size was reached when all kits were consumed. Results abnormal anthropometric measures were detected in 32.9%, either a single or multiple, and 86.5% were breastfed. Girls had significantly higher serum IGF-1 levels than boys (P: <0.001), which was noticeable in girls with abnormal nutritional status detected with anthropometry. Breastfeeding showed no significant association with IGF-1 levels. No significant difference was observed between IGF-1 levels between children with normal versus those with abnormal growth measures. Children with overweight or obesity had significantly lower IGF-1 than children with other body mass index (BMI) categories. Serum IGF-1 levels correlated positively with arm muscle area Z scores in infants and toddlers and weight and BMI Z scores in children between three and four. Also, IGF-1 correlated positively with the triceps skinfold Z score and arm muscle area Z score between four and five. Conclusions Among studied infants and prepubertal children, serum IGF-1 was significantly higher in girls than boys and was considerably lower in children with overweight or obesity. Breastfeeding showed no association with IGF-1 levels.https://doi.org/10.1186/s12887-024-05118-xAnthropometric measuresBreastfeedingGenderIGF-1ObesityShort stature |
| spellingShingle | Hanan Mina Fouad Amal Ahmed Mohamed Nashwa Adel Mohamed Abdulhay Iman Khalifa Randa Ibrahim Naglaa Elsalway Ghada Maher Thabet Karima Nasraldin Ingy Maher El-Hefny Marwa S. Abd El-raouf Dalia Ghareeb Evaluation of insulin-like growth factor-1 in apparently healthy infants and prepubertal Egyptian children with different nutritional statuses BMC Pediatrics Anthropometric measures Breastfeeding Gender IGF-1 Obesity Short stature |
| title | Evaluation of insulin-like growth factor-1 in apparently healthy infants and prepubertal Egyptian children with different nutritional statuses |
| title_full | Evaluation of insulin-like growth factor-1 in apparently healthy infants and prepubertal Egyptian children with different nutritional statuses |
| title_fullStr | Evaluation of insulin-like growth factor-1 in apparently healthy infants and prepubertal Egyptian children with different nutritional statuses |
| title_full_unstemmed | Evaluation of insulin-like growth factor-1 in apparently healthy infants and prepubertal Egyptian children with different nutritional statuses |
| title_short | Evaluation of insulin-like growth factor-1 in apparently healthy infants and prepubertal Egyptian children with different nutritional statuses |
| title_sort | evaluation of insulin like growth factor 1 in apparently healthy infants and prepubertal egyptian children with different nutritional statuses |
| topic | Anthropometric measures Breastfeeding Gender IGF-1 Obesity Short stature |
| url | https://doi.org/10.1186/s12887-024-05118-x |
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