Modulation of motor excitability reflects traveling waves of neural oscillations
Summary: Neural traveling waves represent an important endogenous phenomenon with structural and functional relevance in the human brain. These waves, commonly recorded via electroencephalogram (EEG) or electrocorticography (ECoG), are implicated in a range of brain processes. However, it remains un...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124725006357 |
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| author | Zachary J. Haigh Harry Tran Taylor Berger Sina Shirinpour Ivan Alekseichuk Seth Koenig Jan Zimmermann Robert McGovern David Darrow Alexander Herman Miles Wischnewski Alexander Opitz |
| author_facet | Zachary J. Haigh Harry Tran Taylor Berger Sina Shirinpour Ivan Alekseichuk Seth Koenig Jan Zimmermann Robert McGovern David Darrow Alexander Herman Miles Wischnewski Alexander Opitz |
| author_sort | Zachary J. Haigh |
| collection | DOAJ |
| description | Summary: Neural traveling waves represent an important endogenous phenomenon with structural and functional relevance in the human brain. These waves, commonly recorded via electroencephalogram (EEG) or electrocorticography (ECoG), are implicated in a range of brain processes. However, it remains unclear how they influence neural excitability across brain regions. Advancements in real-time control of brain stimulation present opportunities to compare traveling waves and excitation. Here, we investigate how sensorimotor mu (8–13 Hz) and beta (14–30 Hz) traveling waves affect motor cortex excitability using real-time EEG-controlled transcranial magnetic stimulation (TMS). We observed gradients in the mediolateral direction and then validated these findings using ECoG recordings in a human participant and a nonhuman primate. Our results demonstrate that neuronal excitability reflects the natural patterns of sensorimotor traveling waves. This provides important evidence of traveling waves modulating neural excitability in humans. This opens possibilities for more effective stimulation protocols aligned with intrinsic brain dynamics. |
| format | Article |
| id | doaj-art-227b7a9c4e9145eb88afd013f9d8e94f |
| institution | Kabale University |
| issn | 2211-1247 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj-art-227b7a9c4e9145eb88afd013f9d8e94f2025-08-20T03:45:12ZengElsevierCell Reports2211-12472025-06-0144611586410.1016/j.celrep.2025.115864Modulation of motor excitability reflects traveling waves of neural oscillationsZachary J. Haigh0Harry Tran1Taylor Berger2Sina Shirinpour3Ivan Alekseichuk4Seth Koenig5Jan Zimmermann6Robert McGovern7David Darrow8Alexander Herman9Miles Wischnewski10Alexander Opitz11Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USADepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USADepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USADepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USADepartment of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USADepartment of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA; Department of Neurosurgery, University of Minnesota, Minneapolis, MN, USADepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USADepartment of Neurosurgery, University of Minnesota, Minneapolis, MN, USADepartment of Neurosurgery, University of Minnesota, Minneapolis, MN, USADepartment of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USADepartment of Behavioral and Social Sciences, University of Groningen, Groningen, the NetherlandsDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA; Corresponding authorSummary: Neural traveling waves represent an important endogenous phenomenon with structural and functional relevance in the human brain. These waves, commonly recorded via electroencephalogram (EEG) or electrocorticography (ECoG), are implicated in a range of brain processes. However, it remains unclear how they influence neural excitability across brain regions. Advancements in real-time control of brain stimulation present opportunities to compare traveling waves and excitation. Here, we investigate how sensorimotor mu (8–13 Hz) and beta (14–30 Hz) traveling waves affect motor cortex excitability using real-time EEG-controlled transcranial magnetic stimulation (TMS). We observed gradients in the mediolateral direction and then validated these findings using ECoG recordings in a human participant and a nonhuman primate. Our results demonstrate that neuronal excitability reflects the natural patterns of sensorimotor traveling waves. This provides important evidence of traveling waves modulating neural excitability in humans. This opens possibilities for more effective stimulation protocols aligned with intrinsic brain dynamics.http://www.sciencedirect.com/science/article/pii/S2211124725006357CP: Neuroscience |
| spellingShingle | Zachary J. Haigh Harry Tran Taylor Berger Sina Shirinpour Ivan Alekseichuk Seth Koenig Jan Zimmermann Robert McGovern David Darrow Alexander Herman Miles Wischnewski Alexander Opitz Modulation of motor excitability reflects traveling waves of neural oscillations Cell Reports CP: Neuroscience |
| title | Modulation of motor excitability reflects traveling waves of neural oscillations |
| title_full | Modulation of motor excitability reflects traveling waves of neural oscillations |
| title_fullStr | Modulation of motor excitability reflects traveling waves of neural oscillations |
| title_full_unstemmed | Modulation of motor excitability reflects traveling waves of neural oscillations |
| title_short | Modulation of motor excitability reflects traveling waves of neural oscillations |
| title_sort | modulation of motor excitability reflects traveling waves of neural oscillations |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124725006357 |
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