Cell Based Autologous Immune Enhancement Therapy (AIET) after Radiotherapy in a Locally Advanced Carcinoma of the Cervix
Radiotherapy is the primary form of treatment in patients with locally advanced cervical carcinoma. However for residual disease in the form of the persistent lymph nodes, surgery or chemotherapy is recommended. As surgery is not acceptable by every patient and chemotherapy has associated side effec...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/903094 |
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| author | Sumana Premkumar Vidyasagar Devaprasad Dedeepiya Hiroshi Terunuma Rajappa Senthilkumar Thangavelu Srinivasan Helen C. Reena Senthilkumar Preethy Samuel J. K. Abraham |
| author_facet | Sumana Premkumar Vidyasagar Devaprasad Dedeepiya Hiroshi Terunuma Rajappa Senthilkumar Thangavelu Srinivasan Helen C. Reena Senthilkumar Preethy Samuel J. K. Abraham |
| author_sort | Sumana Premkumar |
| collection | DOAJ |
| description | Radiotherapy is the primary form of treatment in patients with locally advanced cervical carcinoma. However for residual disease in the form of the persistent lymph nodes, surgery or chemotherapy is recommended. As surgery is not acceptable by every patient and chemotherapy has associated side effects, we hereby report the positive outcome of in vitro expanded natural killer cell and activated T lymphocyte based autologous immune enhancement therapy (AIET) for the residual lymphadenopathy in a patient with locally advanced cervical cancer after radiation. After six transfusions of AIET, there was complete resolution of residual lymph nodes and there was no evidence of local lesion. The patient also reported improvement in quality of life. As AIET has been reported as the least toxic among the available therapies for cancer, combining AIET with conventional forms of therapy in similar patients might not only improve the outcome but may also help the patients achieve a good quality of life. |
| format | Article |
| id | doaj-art-227348745a294c37be04733a691f8bdb |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-227348745a294c37be04733a691f8bdb2025-02-03T01:32:11ZengWileyCase Reports in Oncological Medicine2090-67062090-67142013-01-01201310.1155/2013/903094903094Cell Based Autologous Immune Enhancement Therapy (AIET) after Radiotherapy in a Locally Advanced Carcinoma of the CervixSumana Premkumar0Vidyasagar Devaprasad Dedeepiya1Hiroshi Terunuma2Rajappa Senthilkumar3Thangavelu Srinivasan4Helen C. Reena5Senthilkumar Preethy6Samuel J. K. Abraham7Chennai Meenakshi Multispeciality Hospital Limited, New No. 72, Old No. 148, Luz Church Road, Mylapore, Chennai 600 004, IndiaNichi-In Centre for Regenerative Medicine (NCRM), PB 1262, Nungambakkam, Chennai 600034, IndiaBiotherapy Institute of Japan, No. 8, No. 4 Edagawa 2-chome, Koto-ku, Tokyo 135-0051, JapanNichi-In Centre for Regenerative Medicine (NCRM), PB 1262, Nungambakkam, Chennai 600034, IndiaNichi-In Centre for Regenerative Medicine (NCRM), PB 1262, Nungambakkam, Chennai 600034, IndiaNichi-In Centre for Regenerative Medicine (NCRM), PB 1262, Nungambakkam, Chennai 600034, IndiaNichi-In Centre for Regenerative Medicine (NCRM), PB 1262, Nungambakkam, Chennai 600034, IndiaNichi-In Centre for Regenerative Medicine (NCRM), PB 1262, Nungambakkam, Chennai 600034, IndiaRadiotherapy is the primary form of treatment in patients with locally advanced cervical carcinoma. However for residual disease in the form of the persistent lymph nodes, surgery or chemotherapy is recommended. As surgery is not acceptable by every patient and chemotherapy has associated side effects, we hereby report the positive outcome of in vitro expanded natural killer cell and activated T lymphocyte based autologous immune enhancement therapy (AIET) for the residual lymphadenopathy in a patient with locally advanced cervical cancer after radiation. After six transfusions of AIET, there was complete resolution of residual lymph nodes and there was no evidence of local lesion. The patient also reported improvement in quality of life. As AIET has been reported as the least toxic among the available therapies for cancer, combining AIET with conventional forms of therapy in similar patients might not only improve the outcome but may also help the patients achieve a good quality of life.http://dx.doi.org/10.1155/2013/903094 |
| spellingShingle | Sumana Premkumar Vidyasagar Devaprasad Dedeepiya Hiroshi Terunuma Rajappa Senthilkumar Thangavelu Srinivasan Helen C. Reena Senthilkumar Preethy Samuel J. K. Abraham Cell Based Autologous Immune Enhancement Therapy (AIET) after Radiotherapy in a Locally Advanced Carcinoma of the Cervix Case Reports in Oncological Medicine |
| title | Cell Based Autologous Immune Enhancement Therapy (AIET) after Radiotherapy in a Locally Advanced Carcinoma of the Cervix |
| title_full | Cell Based Autologous Immune Enhancement Therapy (AIET) after Radiotherapy in a Locally Advanced Carcinoma of the Cervix |
| title_fullStr | Cell Based Autologous Immune Enhancement Therapy (AIET) after Radiotherapy in a Locally Advanced Carcinoma of the Cervix |
| title_full_unstemmed | Cell Based Autologous Immune Enhancement Therapy (AIET) after Radiotherapy in a Locally Advanced Carcinoma of the Cervix |
| title_short | Cell Based Autologous Immune Enhancement Therapy (AIET) after Radiotherapy in a Locally Advanced Carcinoma of the Cervix |
| title_sort | cell based autologous immune enhancement therapy aiet after radiotherapy in a locally advanced carcinoma of the cervix |
| url | http://dx.doi.org/10.1155/2013/903094 |
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