Understanding Subgenual Cingulate Functional Connectivity in Major Depressive Disorder Using 7T Fmri
Aims: We aimed to determine differences in subgenual anterior cingulate cortex (sgACC) resting-state functional connectivity (rsFC) in Major Depressive Disorder (MDD) vs. healthy volunteers (HV) using 7-Tesla functional magnetic resonance imaging (fMRI). Abnormalities in the sgACC are linked to MDD,...
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| Language: | English |
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Cambridge University Press
2025-06-01
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| Series: | BJPsych Open |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2056472425101920/type/journal_article |
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| author | Laith Alexander Mu Li James Murrough Laurel Morris |
| author_facet | Laith Alexander Mu Li James Murrough Laurel Morris |
| author_sort | Laith Alexander |
| collection | DOAJ |
| description | Aims: We aimed to determine differences in subgenual anterior cingulate cortex (sgACC) resting-state functional connectivity (rsFC) in Major Depressive Disorder (MDD) vs. healthy volunteers (HV) using 7-Tesla functional magnetic resonance imaging (fMRI). Abnormalities in the sgACC are linked to MDD, but the sgACC is anatomically and functionally diverse, including Brodmann area (BA) 25 (Cg25) and the subgenual portion of area 32 (Cg32). The differences in rsFC between Cg25 and Cg32 in MDD compared with HVs have not been directly examined. High-resolution 7T fMRI offers an unrivalled opportunity to measure differences in rsFC between these two subregions which otherwise suffer from signal dropout. |
| format | Article |
| id | doaj-art-227086dc09e340bdb4d307a05ffe87fb |
| institution | Kabale University |
| issn | 2056-4724 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | BJPsych Open |
| spelling | doaj-art-227086dc09e340bdb4d307a05ffe87fb2025-08-20T03:51:44ZengCambridge University PressBJPsych Open2056-47242025-06-0111S19S2010.1192/bjo.2025.10192Understanding Subgenual Cingulate Functional Connectivity in Major Depressive Disorder Using 7T FmriLaith Alexander0Mu Li1James Murrough2Laurel Morris31King’s College London, London, United Kingdom 2South London and Maudsley NHS Foundation Trust, London, United Kingdom3Mount Sinai School of Medicine, New York, USA3Mount Sinai School of Medicine, New York, USA3Mount Sinai School of Medicine, New York, USA 4Nuffield Department of Clinical Neurosciences, Oxford, United KingdomAims: We aimed to determine differences in subgenual anterior cingulate cortex (sgACC) resting-state functional connectivity (rsFC) in Major Depressive Disorder (MDD) vs. healthy volunteers (HV) using 7-Tesla functional magnetic resonance imaging (fMRI). Abnormalities in the sgACC are linked to MDD, but the sgACC is anatomically and functionally diverse, including Brodmann area (BA) 25 (Cg25) and the subgenual portion of area 32 (Cg32). The differences in rsFC between Cg25 and Cg32 in MDD compared with HVs have not been directly examined. High-resolution 7T fMRI offers an unrivalled opportunity to measure differences in rsFC between these two subregions which otherwise suffer from signal dropout.https://www.cambridge.org/core/product/identifier/S2056472425101920/type/journal_article |
| spellingShingle | Laith Alexander Mu Li James Murrough Laurel Morris Understanding Subgenual Cingulate Functional Connectivity in Major Depressive Disorder Using 7T Fmri BJPsych Open |
| title | Understanding Subgenual Cingulate Functional Connectivity in Major Depressive Disorder Using 7T Fmri |
| title_full | Understanding Subgenual Cingulate Functional Connectivity in Major Depressive Disorder Using 7T Fmri |
| title_fullStr | Understanding Subgenual Cingulate Functional Connectivity in Major Depressive Disorder Using 7T Fmri |
| title_full_unstemmed | Understanding Subgenual Cingulate Functional Connectivity in Major Depressive Disorder Using 7T Fmri |
| title_short | Understanding Subgenual Cingulate Functional Connectivity in Major Depressive Disorder Using 7T Fmri |
| title_sort | understanding subgenual cingulate functional connectivity in major depressive disorder using 7t fmri |
| url | https://www.cambridge.org/core/product/identifier/S2056472425101920/type/journal_article |
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