Last Decade Insights in Exploiting Marine Microorganisms as Sources of New Bioactive Natural Products
Marine microorganisms have emerged as prolific sources of bioactive natural products, offering a large chemical diversity and a broad spectrum of biological activities. Over the past decade, significant progress has been made in discovering and characterizing these compounds, pushed by technological...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-03-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/23/3/116 |
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| author | Costanza Ragozzino Vincenza Casella Alessandro Coppola Silvia Scarpato Carmine Buonocore Antonella Consiglio Fortunato Palma Esposito Christian Galasso Pietro Tedesco Gerardo Della Sala Donatella de Pascale Laura Vitale Daniela Coppola |
| author_facet | Costanza Ragozzino Vincenza Casella Alessandro Coppola Silvia Scarpato Carmine Buonocore Antonella Consiglio Fortunato Palma Esposito Christian Galasso Pietro Tedesco Gerardo Della Sala Donatella de Pascale Laura Vitale Daniela Coppola |
| author_sort | Costanza Ragozzino |
| collection | DOAJ |
| description | Marine microorganisms have emerged as prolific sources of bioactive natural products, offering a large chemical diversity and a broad spectrum of biological activities. Over the past decade, significant progress has been made in discovering and characterizing these compounds, pushed by technological innovations in genomics, metabolomics, and bioinformatics. Furthermore, innovative isolation and cultivation approaches have improved the isolation of rare and difficult-to-culture marine microbes, leading to the identification of novel secondary metabolites. Advances in synthetic biology and metabolic engineering have further optimized natural product yields and the generation of novel compounds with improved bioactive properties. This review highlights key developments in the exploitation of marine bacteria, fungi, and microalgae for the discovery of novel natural products with potential applications in diverse fields, underscoring the immense potential of marine microorganisms in the growing Blue Economy sector. |
| format | Article |
| id | doaj-art-226ea1a6b74442cca40dbc3a0de8bb55 |
| institution | DOAJ |
| issn | 1660-3397 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj-art-226ea1a6b74442cca40dbc3a0de8bb552025-08-20T02:42:26ZengMDPI AGMarine Drugs1660-33972025-03-0123311610.3390/md23030116Last Decade Insights in Exploiting Marine Microorganisms as Sources of New Bioactive Natural ProductsCostanza Ragozzino0Vincenza Casella1Alessandro Coppola2Silvia Scarpato3Carmine Buonocore4Antonella Consiglio5Fortunato Palma Esposito6Christian Galasso7Pietro Tedesco8Gerardo Della Sala9Donatella de Pascale10Laura Vitale11Daniela Coppola12Department of Ecosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Via Ammiraglio, Ferdinando Acton 55, 80133 Naples, ItalyDepartment of Ecosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Via Ammiraglio, Ferdinando Acton 55, 80133 Naples, ItalyDepartment of Ecosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Via Ammiraglio, Ferdinando Acton 55, 80133 Naples, ItalyDepartment of Ecosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Via Ammiraglio, Ferdinando Acton 55, 80133 Naples, ItalyDepartment of Ecosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Via Ammiraglio, Ferdinando Acton 55, 80133 Naples, ItalyDepartment of Ecosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Via Ammiraglio, Ferdinando Acton 55, 80133 Naples, ItalyDepartment of Ecosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Via Ammiraglio, Ferdinando Acton 55, 80133 Naples, ItalyDepartment of Ecosustainable Marine Biotechnology, Calabria Marine Centre, CRIMAC, Stazione Zoologica Anton Dohrn, C. da Torre Spaccata, 87071 Amendolara, ItalyDepartment of Ecosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Via Ammiraglio, Ferdinando Acton 55, 80133 Naples, ItalyDepartment of Ecosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Via Ammiraglio, Ferdinando Acton 55, 80133 Naples, ItalyDepartment of Ecosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Via Ammiraglio, Ferdinando Acton 55, 80133 Naples, ItalyDepartment of Ecosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Via Ammiraglio, Ferdinando Acton 55, 80133 Naples, ItalyDepartment of Ecosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Via Ammiraglio, Ferdinando Acton 55, 80133 Naples, ItalyMarine microorganisms have emerged as prolific sources of bioactive natural products, offering a large chemical diversity and a broad spectrum of biological activities. Over the past decade, significant progress has been made in discovering and characterizing these compounds, pushed by technological innovations in genomics, metabolomics, and bioinformatics. Furthermore, innovative isolation and cultivation approaches have improved the isolation of rare and difficult-to-culture marine microbes, leading to the identification of novel secondary metabolites. Advances in synthetic biology and metabolic engineering have further optimized natural product yields and the generation of novel compounds with improved bioactive properties. This review highlights key developments in the exploitation of marine bacteria, fungi, and microalgae for the discovery of novel natural products with potential applications in diverse fields, underscoring the immense potential of marine microorganisms in the growing Blue Economy sector.https://www.mdpi.com/1660-3397/23/3/116natural productsmarine microorganismsmetabologenomicshigh-throughput screeningbioinformatic toolsbioactivity |
| spellingShingle | Costanza Ragozzino Vincenza Casella Alessandro Coppola Silvia Scarpato Carmine Buonocore Antonella Consiglio Fortunato Palma Esposito Christian Galasso Pietro Tedesco Gerardo Della Sala Donatella de Pascale Laura Vitale Daniela Coppola Last Decade Insights in Exploiting Marine Microorganisms as Sources of New Bioactive Natural Products Marine Drugs natural products marine microorganisms metabologenomics high-throughput screening bioinformatic tools bioactivity |
| title | Last Decade Insights in Exploiting Marine Microorganisms as Sources of New Bioactive Natural Products |
| title_full | Last Decade Insights in Exploiting Marine Microorganisms as Sources of New Bioactive Natural Products |
| title_fullStr | Last Decade Insights in Exploiting Marine Microorganisms as Sources of New Bioactive Natural Products |
| title_full_unstemmed | Last Decade Insights in Exploiting Marine Microorganisms as Sources of New Bioactive Natural Products |
| title_short | Last Decade Insights in Exploiting Marine Microorganisms as Sources of New Bioactive Natural Products |
| title_sort | last decade insights in exploiting marine microorganisms as sources of new bioactive natural products |
| topic | natural products marine microorganisms metabologenomics high-throughput screening bioinformatic tools bioactivity |
| url | https://www.mdpi.com/1660-3397/23/3/116 |
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