Role of Air Pollution and rs10830963 Polymorphism on the Incidence of Type 2 Diabetes: Tehran Cardiometabolic Genetic Study
Diabetes mellitus (DM) is considered one of the leading health issues that are egregiously threatening human life throughout the world. Several epidemiological studies have examined the relationship of a particular matter<10 μm (PM10) exposure and with type 2 diabetes mellitus (T2DM) prevalence a...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/2928618 |
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| author | Fatemeh Jabbari Anoushiravan Mohseni Bandpei Maryam S. Daneshpour Abbas Shahsavani Seyed Saeed Hashemi Nazari Hassanali Faraji Sabokbar Amir abbas Momenan Fereidoun Azizi |
| author_facet | Fatemeh Jabbari Anoushiravan Mohseni Bandpei Maryam S. Daneshpour Abbas Shahsavani Seyed Saeed Hashemi Nazari Hassanali Faraji Sabokbar Amir abbas Momenan Fereidoun Azizi |
| author_sort | Fatemeh Jabbari |
| collection | DOAJ |
| description | Diabetes mellitus (DM) is considered one of the leading health issues that are egregiously threatening human life throughout the world. Several epidemiological studies have examined the relationship of a particular matter<10 μm (PM10) exposure and with type 2 diabetes mellitus (T2DM) prevalence and incidence. Accordingly, the current study is a study investigating the independent influence of air pollution (AP) and rs10830963 on the incidence of T2DM. A total number of 2428 adults over 20 years of age participated in a prospective cohort (TCGS) during a 9-year follow-up phase. The concentration of AP was measured, and the obtained values were considered the mean level in three previous years since the exposure concentration took the people living in that location. The COX regression model was employed to determine the influence of AP and rs10830963 on the incidence of T2DM in adjustment with covariate factors. Among the 392 T2DM, 230 cases (58.7%) were female diabetics, and 162 (41.3%) were male diabetics. According to the multivariable-adjusted model, exposure to PM10 (per 10 μm/m3), associated with the risk of T2DM, although just a borderline (p=0.07) was found in the multivariable model (HR; 1.50, 95% CI; 1-2.32). The rs10830963 was directly associated with the incidence of diabetes, and the GG genotype increased the T2DM rate by 113% (more than two times) (HR; 2.134, 95% CI; 1.42-3.21, p≤0.001) and GC increased it by 65% (HR; 1.65, 95% CI; 1.24-2.21, p≤0.001). Long-term exposure to PM10 was associated with an increased risk of diabetes. Thus, it is suggested that the individuals with variant rs10830963 genotypes fall within a group susceptible to an increased risk of T2DM arising from AP. |
| format | Article |
| id | doaj-art-226b26fd55e54f5a8de78b7ee5de23df |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-226b26fd55e54f5a8de78b7ee5de23df2025-08-20T03:54:48ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/29286182928618Role of Air Pollution and rs10830963 Polymorphism on the Incidence of Type 2 Diabetes: Tehran Cardiometabolic Genetic StudyFatemeh Jabbari0Anoushiravan Mohseni Bandpei1Maryam S. Daneshpour2Abbas Shahsavani3Seyed Saeed Hashemi Nazari4Hassanali Faraji Sabokbar5Amir abbas Momenan6Fereidoun Azizi7Department of Environmental Health Engineering, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, IranEnvironmental and Occupational Hazards Control Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranCellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranEnvironmental and Occupational Hazards Control Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranPrevention of Cardiovascular Disease Research Center, Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Science, Tehran, IranDepartment of Human Geography, Tehran University of Sciences, Tehran, IranPrevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranEndocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranDiabetes mellitus (DM) is considered one of the leading health issues that are egregiously threatening human life throughout the world. Several epidemiological studies have examined the relationship of a particular matter<10 μm (PM10) exposure and with type 2 diabetes mellitus (T2DM) prevalence and incidence. Accordingly, the current study is a study investigating the independent influence of air pollution (AP) and rs10830963 on the incidence of T2DM. A total number of 2428 adults over 20 years of age participated in a prospective cohort (TCGS) during a 9-year follow-up phase. The concentration of AP was measured, and the obtained values were considered the mean level in three previous years since the exposure concentration took the people living in that location. The COX regression model was employed to determine the influence of AP and rs10830963 on the incidence of T2DM in adjustment with covariate factors. Among the 392 T2DM, 230 cases (58.7%) were female diabetics, and 162 (41.3%) were male diabetics. According to the multivariable-adjusted model, exposure to PM10 (per 10 μm/m3), associated with the risk of T2DM, although just a borderline (p=0.07) was found in the multivariable model (HR; 1.50, 95% CI; 1-2.32). The rs10830963 was directly associated with the incidence of diabetes, and the GG genotype increased the T2DM rate by 113% (more than two times) (HR; 2.134, 95% CI; 1.42-3.21, p≤0.001) and GC increased it by 65% (HR; 1.65, 95% CI; 1.24-2.21, p≤0.001). Long-term exposure to PM10 was associated with an increased risk of diabetes. Thus, it is suggested that the individuals with variant rs10830963 genotypes fall within a group susceptible to an increased risk of T2DM arising from AP.http://dx.doi.org/10.1155/2020/2928618 |
| spellingShingle | Fatemeh Jabbari Anoushiravan Mohseni Bandpei Maryam S. Daneshpour Abbas Shahsavani Seyed Saeed Hashemi Nazari Hassanali Faraji Sabokbar Amir abbas Momenan Fereidoun Azizi Role of Air Pollution and rs10830963 Polymorphism on the Incidence of Type 2 Diabetes: Tehran Cardiometabolic Genetic Study Journal of Diabetes Research |
| title | Role of Air Pollution and rs10830963 Polymorphism on the Incidence of Type 2 Diabetes: Tehran Cardiometabolic Genetic Study |
| title_full | Role of Air Pollution and rs10830963 Polymorphism on the Incidence of Type 2 Diabetes: Tehran Cardiometabolic Genetic Study |
| title_fullStr | Role of Air Pollution and rs10830963 Polymorphism on the Incidence of Type 2 Diabetes: Tehran Cardiometabolic Genetic Study |
| title_full_unstemmed | Role of Air Pollution and rs10830963 Polymorphism on the Incidence of Type 2 Diabetes: Tehran Cardiometabolic Genetic Study |
| title_short | Role of Air Pollution and rs10830963 Polymorphism on the Incidence of Type 2 Diabetes: Tehran Cardiometabolic Genetic Study |
| title_sort | role of air pollution and rs10830963 polymorphism on the incidence of type 2 diabetes tehran cardiometabolic genetic study |
| url | http://dx.doi.org/10.1155/2020/2928618 |
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