Systematic literature review on Calcium Pyrophosphate Deposition (CPPD) nomenclature: condition elements and clinical states— A Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus project
Objectives The Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) has developed a calcium pyrophosphate deposition (CPPD) nomenclature project. This systematic literature review constituted its first step and aimed to provide a state-of-the-art analysis of the medical literature of...
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BMJ Publishing Group
2025-01-01
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| Series: | RMD Open |
| Online Access: | https://rmdopen.bmj.com/content/11/1/e004847.full |
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| author | Georgios Filippou Antonella Adinolfi Emilio Filippucci Nicola Dalbeth Robert Terkeltaub Tristan Pascart Edoardo Cipolletta Silvia Sirotti Charlotte Jauffret Sara Tedeschi Daniele Cirillo Luca Ingrao Alessandro Lucia |
| author_facet | Georgios Filippou Antonella Adinolfi Emilio Filippucci Nicola Dalbeth Robert Terkeltaub Tristan Pascart Edoardo Cipolletta Silvia Sirotti Charlotte Jauffret Sara Tedeschi Daniele Cirillo Luca Ingrao Alessandro Lucia |
| author_sort | Georgios Filippou |
| collection | DOAJ |
| description | Objectives The Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) has developed a calcium pyrophosphate deposition (CPPD) nomenclature project. This systematic literature review constituted its first step and aimed to provide a state-of-the-art analysis of the medical literature of the last 20 years.Methods A systematic literature search was undertaken in the PubMed, Cochrane and Embase databases between 2000 and 2022, restricted to studies on humans and in the English language. Eight reviewers independently and manually extracted labels related to CPPD concepts, according to an a priori list generated by the authors: pathogenic conditions and pathogenic crystal labels, elementary imaging condition elements and asymptomatic and symptomatic condition states. For each concept, labels were analysed to determine their frequency.Results Among the 2375 articles identified, 886 articles were included, of which 394 (44.5%) were case reports and 169 (19.0%) were scoping reviews. Overall, the most common labels used to designate the pathogenic condition were ‘pseudogout’ in 365/783 (46.6%), ‘chondrocalcinosis’ in 207/783 (26.4%) and ‘calcium pyrophosphate deposition disease’ in 181/783 (23.1%) occurrences. The most common abbreviation was ‘CPPD’ in 312/390 (80.0%), but with different meanings. CPPD clinical phenotypes were often described as ‘pseudo-form’ labels.Conclusion Those results demonstrate the heterogeneity of labels used to describe CPPD condition concepts, with wide variation in condition labels in the medical literature. This work provides the rationale and basis to achieve agreement about CPPD technical nomenclature. |
| format | Article |
| id | doaj-art-225f1fdc23494f4ea83b2897329e0aaf |
| institution | Kabale University |
| issn | 2056-5933 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | RMD Open |
| spelling | doaj-art-225f1fdc23494f4ea83b2897329e0aaf2025-01-31T22:10:08ZengBMJ Publishing GroupRMD Open2056-59332025-01-0111110.1136/rmdopen-2024-004847Systematic literature review on Calcium Pyrophosphate Deposition (CPPD) nomenclature: condition elements and clinical states— A Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus projectGeorgios Filippou0Antonella Adinolfi1Emilio Filippucci2Nicola Dalbeth3Robert Terkeltaub4Tristan Pascart5Edoardo Cipolletta6Silvia Sirotti7Charlotte Jauffret8Sara Tedeschi9Daniele Cirillo10Luca Ingrao11Alessandro Lucia12Department of Biomedical and Clinical Sciences, Università degli Studi di Milano, Milano, ItalyRheumatology unit, ASST Grande Ospedale Metropolitano Niguarda, Milano, ItalyRheumatology Unit - Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, ItalyDepartment of Medicine, University of Auckland, Auckland, New ZealandDivision of Rheumatology, Autoimmunity, and Inflammation, University of California San Diego, La Jolla, California, USADepartment of Rheumatology, Lille Catholic University, Saint-Philibert Hospital, Lomme, FranceRheumatology Unit - Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, ItalyRheumatology Department, IRCCS Galeazzi – Sant’Ambrogio Hospital, Milan, ItalyRheumatology Department, Lille Catholic University, Saint Philibert Hospital, EA 7446 - ETHICS, Lille, FranceDivision of Rheumatology, Inflammation and Immunity, Brigham and Women`s Hospital, Boston, Massachusetts, USADepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, Milano, ItalyDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, Milano, ItalyDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, Milano, ItalyObjectives The Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) has developed a calcium pyrophosphate deposition (CPPD) nomenclature project. This systematic literature review constituted its first step and aimed to provide a state-of-the-art analysis of the medical literature of the last 20 years.Methods A systematic literature search was undertaken in the PubMed, Cochrane and Embase databases between 2000 and 2022, restricted to studies on humans and in the English language. Eight reviewers independently and manually extracted labels related to CPPD concepts, according to an a priori list generated by the authors: pathogenic conditions and pathogenic crystal labels, elementary imaging condition elements and asymptomatic and symptomatic condition states. For each concept, labels were analysed to determine their frequency.Results Among the 2375 articles identified, 886 articles were included, of which 394 (44.5%) were case reports and 169 (19.0%) were scoping reviews. Overall, the most common labels used to designate the pathogenic condition were ‘pseudogout’ in 365/783 (46.6%), ‘chondrocalcinosis’ in 207/783 (26.4%) and ‘calcium pyrophosphate deposition disease’ in 181/783 (23.1%) occurrences. The most common abbreviation was ‘CPPD’ in 312/390 (80.0%), but with different meanings. CPPD clinical phenotypes were often described as ‘pseudo-form’ labels.Conclusion Those results demonstrate the heterogeneity of labels used to describe CPPD condition concepts, with wide variation in condition labels in the medical literature. This work provides the rationale and basis to achieve agreement about CPPD technical nomenclature.https://rmdopen.bmj.com/content/11/1/e004847.full |
| spellingShingle | Georgios Filippou Antonella Adinolfi Emilio Filippucci Nicola Dalbeth Robert Terkeltaub Tristan Pascart Edoardo Cipolletta Silvia Sirotti Charlotte Jauffret Sara Tedeschi Daniele Cirillo Luca Ingrao Alessandro Lucia Systematic literature review on Calcium Pyrophosphate Deposition (CPPD) nomenclature: condition elements and clinical states— A Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus project RMD Open |
| title | Systematic literature review on Calcium Pyrophosphate Deposition (CPPD) nomenclature: condition elements and clinical states— A Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus project |
| title_full | Systematic literature review on Calcium Pyrophosphate Deposition (CPPD) nomenclature: condition elements and clinical states— A Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus project |
| title_fullStr | Systematic literature review on Calcium Pyrophosphate Deposition (CPPD) nomenclature: condition elements and clinical states— A Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus project |
| title_full_unstemmed | Systematic literature review on Calcium Pyrophosphate Deposition (CPPD) nomenclature: condition elements and clinical states— A Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus project |
| title_short | Systematic literature review on Calcium Pyrophosphate Deposition (CPPD) nomenclature: condition elements and clinical states— A Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus project |
| title_sort | systematic literature review on calcium pyrophosphate deposition cppd nomenclature condition elements and clinical states a gout hyperuricaemia and crystal associated disease network g can consensus project |
| url | https://rmdopen.bmj.com/content/11/1/e004847.full |
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