Global bone cancer incidence and death rate analysis at 40 years
Abstract Background Bone cancer exhibits significant global disparities in incidence and mortality. Understanding these trends is essential for identifying high-risk populations and informing targeted interventions. Methods Using data from the Global Burden of Disease Study 2021 (GBD 2021) and the C...
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| Format: | Article |
| Language: | English |
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Springer
2025-06-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-02917-1 |
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| author | Peiran Liu Hang Lv Yongji Li Zelin Liu Xiangjun Yang Hai Hu |
| author_facet | Peiran Liu Hang Lv Yongji Li Zelin Liu Xiangjun Yang Hai Hu |
| author_sort | Peiran Liu |
| collection | DOAJ |
| description | Abstract Background Bone cancer exhibits significant global disparities in incidence and mortality. Understanding these trends is essential for identifying high-risk populations and informing targeted interventions. Methods Using data from the Global Burden of Disease Study 2021 (GBD 2021) and the Cancer Incidence in Five Continents (CI5) database, this study analyzed bone cancer incidence (1993–2017) and mortality (1980–2021) trends. Age-standardized incidence rates (ASRs, per 100,000) and mortality rates were assessed across regions, countries, income levels, and health systems, focusing on gender differences and healthcare capacity. Results Bone cancer ASRs (1993–2017) ranged from 0.53 to 2.72 for females (China: Yunmeng County, 2.72 [2.16–3.28]) and 0.90–4.28 for males (China: Xiangfu District, 4.28 [3.25–5.31], p < 0.0001), with minimal rates near zero like Brazil: Jau and USA: Hawaii Chinese. Mortality rates (1980–2021) peaked in Eastern Europe and Central Asia, with male rates up to 2.90 (Romania, 2.90 [1.89–3.90], 1980) and female rates up to 2.34 (Greece, 2.34 [2.11–2.58], 1980), while high-income regions like Western Europe declined to 0.84 (males, 0.84 [0.76–0.90], 2021). By 2021, Upper Middle-Income countries (1.26 [0.85–1.62] for males) and Basic Health Systems (1.27 [0.85–1.59] for males) showed rising mortality, surpassing Advanced Health Systems (0.76 [0.71–0.81] for males), reflecting healthcare disparities. Thailand (males, 2.06 [1.18–3.01], 2021) and China saw increasing rates, unlike stable low rates in the USA (males, 0.71 [0.67–0.74], 2021). Conclusions Bone cancer incidence and mortality are heavily influenced by healthcare system capacity and socioeconomic factors. |
| format | Article |
| id | doaj-art-2252c7ffeb6e4d49b4ecce78d4c18238 |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-2252c7ffeb6e4d49b4ecce78d4c182382025-08-20T03:45:11ZengSpringerDiscover Oncology2730-60112025-06-0116112410.1007/s12672-025-02917-1Global bone cancer incidence and death rate analysis at 40 yearsPeiran Liu0Hang Lv1Yongji Li2Zelin Liu3Xiangjun Yang4Hai Hu5Department of Bone Injuries, Hanan Branch of the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese medicineDepartment of Bone Injuries, Hanan Branch of the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese medicineDepartment of Bone Injuries, Hanan Branch of the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese medicineDepartment of Medical Services Division, The Second Affiliated Hospital of Heilongjiang University of Traditional Chinese medicineDepartment of Bone Injuries, Hanan Branch of the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese medicineDepartment of Bone Injuries, Hanan Branch of the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese medicineAbstract Background Bone cancer exhibits significant global disparities in incidence and mortality. Understanding these trends is essential for identifying high-risk populations and informing targeted interventions. Methods Using data from the Global Burden of Disease Study 2021 (GBD 2021) and the Cancer Incidence in Five Continents (CI5) database, this study analyzed bone cancer incidence (1993–2017) and mortality (1980–2021) trends. Age-standardized incidence rates (ASRs, per 100,000) and mortality rates were assessed across regions, countries, income levels, and health systems, focusing on gender differences and healthcare capacity. Results Bone cancer ASRs (1993–2017) ranged from 0.53 to 2.72 for females (China: Yunmeng County, 2.72 [2.16–3.28]) and 0.90–4.28 for males (China: Xiangfu District, 4.28 [3.25–5.31], p < 0.0001), with minimal rates near zero like Brazil: Jau and USA: Hawaii Chinese. Mortality rates (1980–2021) peaked in Eastern Europe and Central Asia, with male rates up to 2.90 (Romania, 2.90 [1.89–3.90], 1980) and female rates up to 2.34 (Greece, 2.34 [2.11–2.58], 1980), while high-income regions like Western Europe declined to 0.84 (males, 0.84 [0.76–0.90], 2021). By 2021, Upper Middle-Income countries (1.26 [0.85–1.62] for males) and Basic Health Systems (1.27 [0.85–1.59] for males) showed rising mortality, surpassing Advanced Health Systems (0.76 [0.71–0.81] for males), reflecting healthcare disparities. Thailand (males, 2.06 [1.18–3.01], 2021) and China saw increasing rates, unlike stable low rates in the USA (males, 0.71 [0.67–0.74], 2021). Conclusions Bone cancer incidence and mortality are heavily influenced by healthcare system capacity and socioeconomic factors.https://doi.org/10.1007/s12672-025-02917-1ChondrosarcomaGlobal burdenHealthcare infrastructureOsteosarcomaRegional health disparities |
| spellingShingle | Peiran Liu Hang Lv Yongji Li Zelin Liu Xiangjun Yang Hai Hu Global bone cancer incidence and death rate analysis at 40 years Discover Oncology Chondrosarcoma Global burden Healthcare infrastructure Osteosarcoma Regional health disparities |
| title | Global bone cancer incidence and death rate analysis at 40 years |
| title_full | Global bone cancer incidence and death rate analysis at 40 years |
| title_fullStr | Global bone cancer incidence and death rate analysis at 40 years |
| title_full_unstemmed | Global bone cancer incidence and death rate analysis at 40 years |
| title_short | Global bone cancer incidence and death rate analysis at 40 years |
| title_sort | global bone cancer incidence and death rate analysis at 40 years |
| topic | Chondrosarcoma Global burden Healthcare infrastructure Osteosarcoma Regional health disparities |
| url | https://doi.org/10.1007/s12672-025-02917-1 |
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