Inhibition of miMOMP-induced SASP to combat age-related disease
Cellular senescence, first described in 1961, was initially observed in normal human fibroblasts that ceased proliferating after a finite number of divisions in culture. This process is triggered by various stimuli, including oxidative stress, chromatin modifications and oncogene activation, charact...
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| Format: | Article |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Aging |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fragi.2025.1505063/full |
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| author | Xiaoli Liao Zhennan Guo Zhennan Guo Mouhai He Yichun Zhang |
| author_facet | Xiaoli Liao Zhennan Guo Zhennan Guo Mouhai He Yichun Zhang |
| author_sort | Xiaoli Liao |
| collection | DOAJ |
| description | Cellular senescence, first described in 1961, was initially observed in normal human fibroblasts that ceased proliferating after a finite number of divisions in culture. This process is triggered by various stimuli, including oxidative stress, chromatin modifications and oncogene activation, characterized by irreversible cell-cycle arrest, resistance to apoptosis and the induction of a complex senescent associated secretory phenotype (SASP). Over the past decade, emerging evidence has linked cellular senescence to the aging process and a wide range of chronic age-related diseases. Consequently, research focused on targeting senescence to alleviate or delay age-related disease, referred to as senotherapy, has been conducted rapidly. Therefore, elucidating the mechanisms of cellular senescence is essential for providing practical strategies aimed at addressing this condition. |
| format | Article |
| id | doaj-art-224ce9e37e814e1fb007ffe3f913f626 |
| institution | Kabale University |
| issn | 2673-6217 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging |
| spelling | doaj-art-224ce9e37e814e1fb007ffe3f913f6262025-01-29T06:46:14ZengFrontiers Media S.A.Frontiers in Aging2673-62172025-01-01610.3389/fragi.2025.15050631505063Inhibition of miMOMP-induced SASP to combat age-related diseaseXiaoli Liao0Zhennan Guo1Zhennan Guo2Mouhai He3Yichun Zhang4School of Medical Technology and Nursing, Hunan institute of traffic engineering, Hengyang, ChinaSchool of Medical Technology and Nursing, Hunan institute of traffic engineering, Hengyang, ChinaHengyang Xin Yahan Medical Beauty Clinic, Hengyang, ChinaSchool of Medical Technology and Nursing, Hunan institute of traffic engineering, Hengyang, ChinaSchool of Medical Technology and Nursing, Hunan institute of traffic engineering, Hengyang, ChinaCellular senescence, first described in 1961, was initially observed in normal human fibroblasts that ceased proliferating after a finite number of divisions in culture. This process is triggered by various stimuli, including oxidative stress, chromatin modifications and oncogene activation, characterized by irreversible cell-cycle arrest, resistance to apoptosis and the induction of a complex senescent associated secretory phenotype (SASP). Over the past decade, emerging evidence has linked cellular senescence to the aging process and a wide range of chronic age-related diseases. Consequently, research focused on targeting senescence to alleviate or delay age-related disease, referred to as senotherapy, has been conducted rapidly. Therefore, elucidating the mechanisms of cellular senescence is essential for providing practical strategies aimed at addressing this condition.https://www.frontiersin.org/articles/10.3389/fragi.2025.1505063/fullmiMOMPSASP (senescence-associated secretory phenotype)age-related diseasecGAS-STINGmtDNA |
| spellingShingle | Xiaoli Liao Zhennan Guo Zhennan Guo Mouhai He Yichun Zhang Inhibition of miMOMP-induced SASP to combat age-related disease Frontiers in Aging miMOMP SASP (senescence-associated secretory phenotype) age-related disease cGAS-STING mtDNA |
| title | Inhibition of miMOMP-induced SASP to combat age-related disease |
| title_full | Inhibition of miMOMP-induced SASP to combat age-related disease |
| title_fullStr | Inhibition of miMOMP-induced SASP to combat age-related disease |
| title_full_unstemmed | Inhibition of miMOMP-induced SASP to combat age-related disease |
| title_short | Inhibition of miMOMP-induced SASP to combat age-related disease |
| title_sort | inhibition of mimomp induced sasp to combat age related disease |
| topic | miMOMP SASP (senescence-associated secretory phenotype) age-related disease cGAS-STING mtDNA |
| url | https://www.frontiersin.org/articles/10.3389/fragi.2025.1505063/full |
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