Functional Translational Readthrough: A Systems Biology Perspective.
Translational readthrough (TR) has come into renewed focus because systems biology approaches have identified the first human genes undergoing functional translational readthrough (FTR). FTR creates functional extensions to proteins by continuing translation of the mRNA downstream of the stop codon....
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-08-01
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| Series: | PLoS Genetics |
| Online Access: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1006196&type=printable |
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| _version_ | 1850231302441140224 |
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| author | Fabian Schueren Sven Thoms |
| author_facet | Fabian Schueren Sven Thoms |
| author_sort | Fabian Schueren |
| collection | DOAJ |
| description | Translational readthrough (TR) has come into renewed focus because systems biology approaches have identified the first human genes undergoing functional translational readthrough (FTR). FTR creates functional extensions to proteins by continuing translation of the mRNA downstream of the stop codon. Here we review recent developments in TR research with a focus on the identification of FTR in humans and the systems biology methods that have spurred these discoveries. |
| format | Article |
| id | doaj-art-224b3d2624de4f2582992f5971901034 |
| institution | OA Journals |
| issn | 1553-7390 1553-7404 |
| language | English |
| publishDate | 2016-08-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj-art-224b3d2624de4f2582992f59719010342025-08-20T02:03:35ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042016-08-01128e100619610.1371/journal.pgen.1006196Functional Translational Readthrough: A Systems Biology Perspective.Fabian SchuerenSven ThomsTranslational readthrough (TR) has come into renewed focus because systems biology approaches have identified the first human genes undergoing functional translational readthrough (FTR). FTR creates functional extensions to proteins by continuing translation of the mRNA downstream of the stop codon. Here we review recent developments in TR research with a focus on the identification of FTR in humans and the systems biology methods that have spurred these discoveries.https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1006196&type=printable |
| spellingShingle | Fabian Schueren Sven Thoms Functional Translational Readthrough: A Systems Biology Perspective. PLoS Genetics |
| title | Functional Translational Readthrough: A Systems Biology Perspective. |
| title_full | Functional Translational Readthrough: A Systems Biology Perspective. |
| title_fullStr | Functional Translational Readthrough: A Systems Biology Perspective. |
| title_full_unstemmed | Functional Translational Readthrough: A Systems Biology Perspective. |
| title_short | Functional Translational Readthrough: A Systems Biology Perspective. |
| title_sort | functional translational readthrough a systems biology perspective |
| url | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1006196&type=printable |
| work_keys_str_mv | AT fabianschueren functionaltranslationalreadthroughasystemsbiologyperspective AT sventhoms functionaltranslationalreadthroughasystemsbiologyperspective |