Emerging roles of RNA methylation modifications in environmental metalloid or metal pollutants toxicity
The common environmental metalloid or metal pollutants such as arsenic, cadmium, chromium, lead, aluminum, cobalt and manganese have increasingly significant impacts on public health. They have been confirmed to be enriched step by step through the food chain to display serious toxic effects on mult...
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| Language: | English |
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Elsevier
2025-07-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325007201 |
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| author | Rongxian Li Yuan Zhao Jiao Dai Nan Zhang Jiamin Yuan De Liu Zuoshun He Jie Yang Shiyan Gu |
| author_facet | Rongxian Li Yuan Zhao Jiao Dai Nan Zhang Jiamin Yuan De Liu Zuoshun He Jie Yang Shiyan Gu |
| author_sort | Rongxian Li |
| collection | DOAJ |
| description | The common environmental metalloid or metal pollutants such as arsenic, cadmium, chromium, lead, aluminum, cobalt and manganese have increasingly significant impacts on public health. They have been confirmed to be enriched step by step through the food chain to display serious toxic effects on multiple organs and tissues. Recently, emerging studies have indicated that RNA methylation modification plays essential roles in various organs and tissue toxicity under the treatment of environmental metalloid or metal pollutants. In this review, the roles and mechanisms of major RNA methylation modifications such as N6-methyladenosine (m6A), 5-methylcytosine (m5C), N1-methyladenosine (m1A) and 7-methylguanine (m7G) in the regulation of multiple organs and tissues toxic damage caused by environmental metalloid or metal pollutants are summarized. Additionally, we explore potential avenues for future investigation within the realm of RNA methylation as it pertains to the toxicity of environmental metalloid or metal pollutants. The insights presented herein are intended to offer critical research leads and a scientific foundation for the mitigation and advancement of strategies addressing the toxicity of environmental metalloid or metal pollutants. |
| format | Article |
| id | doaj-art-223bfee4d4a841bea7f088a063b0a8b1 |
| institution | OA Journals |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-223bfee4d4a841bea7f088a063b0a8b12025-08-20T02:32:26ZengElsevierEcotoxicology and Environmental Safety0147-65132025-07-0129911838410.1016/j.ecoenv.2025.118384Emerging roles of RNA methylation modifications in environmental metalloid or metal pollutants toxicityRongxian Li0Yuan Zhao1Jiao Dai2Nan Zhang3Jiamin Yuan4De Liu5Zuoshun He6Jie Yang7Shiyan Gu8School of Public Health, Dali University, Dali, Yunnan 671000, China; Institute of Preventive Medicine, Dali University, Dali, Yunnan 671000, ChinaSchool of Public Health, Dali University, Dali, Yunnan 671000, China; Institute of Preventive Medicine, Dali University, Dali, Yunnan 671000, ChinaQujing Medical College, Qujing, Yunnan 655000, ChinaSchool of Public Health, Dali University, Dali, Yunnan 671000, China; Institute of Preventive Medicine, Dali University, Dali, Yunnan 671000, ChinaSchool of Public Health, Dali University, Dali, Yunnan 671000, China; Institute of Preventive Medicine, Dali University, Dali, Yunnan 671000, ChinaSchool of Public Health, Dali University, Dali, Yunnan 671000, China; Institute of Preventive Medicine, Dali University, Dali, Yunnan 671000, ChinaSchool of Public Health, Dali University, Dali, Yunnan 671000, China; Institute of Preventive Medicine, Dali University, Dali, Yunnan 671000, ChinaCollege of Engineering, Dali University, Dali, Yunnan 671000, China; Correspondence to: College of Engineering, Dali University, No. 2, Hongsheng Road, Dali, Yunnan 671003, China.School of Public Health, Dali University, Dali, Yunnan 671000, China; Institute of Preventive Medicine, Dali University, Dali, Yunnan 671000, China; Correspondence to: Institute of Preventive Medicine, School of Public Health, Dali University, No. 22, Wanhua Road, Dali, Yunnan 671000, China.The common environmental metalloid or metal pollutants such as arsenic, cadmium, chromium, lead, aluminum, cobalt and manganese have increasingly significant impacts on public health. They have been confirmed to be enriched step by step through the food chain to display serious toxic effects on multiple organs and tissues. Recently, emerging studies have indicated that RNA methylation modification plays essential roles in various organs and tissue toxicity under the treatment of environmental metalloid or metal pollutants. In this review, the roles and mechanisms of major RNA methylation modifications such as N6-methyladenosine (m6A), 5-methylcytosine (m5C), N1-methyladenosine (m1A) and 7-methylguanine (m7G) in the regulation of multiple organs and tissues toxic damage caused by environmental metalloid or metal pollutants are summarized. Additionally, we explore potential avenues for future investigation within the realm of RNA methylation as it pertains to the toxicity of environmental metalloid or metal pollutants. The insights presented herein are intended to offer critical research leads and a scientific foundation for the mitigation and advancement of strategies addressing the toxicity of environmental metalloid or metal pollutants.http://www.sciencedirect.com/science/article/pii/S0147651325007201RNA methylation modificationsN6-methyladenosine5-methylcytosineArsenicCadmium |
| spellingShingle | Rongxian Li Yuan Zhao Jiao Dai Nan Zhang Jiamin Yuan De Liu Zuoshun He Jie Yang Shiyan Gu Emerging roles of RNA methylation modifications in environmental metalloid or metal pollutants toxicity Ecotoxicology and Environmental Safety RNA methylation modifications N6-methyladenosine 5-methylcytosine Arsenic Cadmium |
| title | Emerging roles of RNA methylation modifications in environmental metalloid or metal pollutants toxicity |
| title_full | Emerging roles of RNA methylation modifications in environmental metalloid or metal pollutants toxicity |
| title_fullStr | Emerging roles of RNA methylation modifications in environmental metalloid or metal pollutants toxicity |
| title_full_unstemmed | Emerging roles of RNA methylation modifications in environmental metalloid or metal pollutants toxicity |
| title_short | Emerging roles of RNA methylation modifications in environmental metalloid or metal pollutants toxicity |
| title_sort | emerging roles of rna methylation modifications in environmental metalloid or metal pollutants toxicity |
| topic | RNA methylation modifications N6-methyladenosine 5-methylcytosine Arsenic Cadmium |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325007201 |
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