Pharmacogenetic associations of MMP9 and MMP12 variants with cardiovascular disease in patients with hypertension.

Pharmacogenetic associations of MMP9 and MMP12 variants with cardiovascular disease in patients with hypertension.

<h4>Objectives</h4>MMP-9 and -12 function in tissue remodeling and may play roles in cardiovascular disease (CVD). We assessed associations of four MMP polymorphisms and three antihypertensive drugs with cardiovascular outcomes.<h4>Methods</h4>Hypertensives (n = 42,418) from...

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Main Authors: Rikki M Tanner, Amy I Lynch, Victoria H Brophy, John H Eckfeldt, Barry R Davis, Charles E Ford, Eric Boerwinkle, Donna K Arnett
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0023609&type=printable
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