Local depletion of large molecule drugs due to target binding in tissue interstitial space
Abstract Drug–target binding determines a drug's pharmacodynamics but can also have a profound impact on a drug's pharmacokinetics, known as target‐mediated drug disposition (TMDD). TMDD models describe the influence of drug–target binding and target turnover on unbound drug concentrations...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-12-01
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| Series: | CPT: Pharmacometrics & Systems Pharmacology |
| Online Access: | https://doi.org/10.1002/psp4.13262 |
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