Fecal microbiota transplantation through colonoscopy for the management of severe refractory irritable bowel syndrome: Preliminary results

Fecal microbiota transplantation through colonoscopy for the management of severe refractory irritable bowel syndrome: Preliminary results

Recent studies have explored the role of the microbiota in disorders of gut-brain interaction, opening pathways for therapies, such as dietary adjustments, probiotics, and fecal microbiota transplantation (FMT). We present herein a pilot study on 4 patients with severe irritable bowel syndrome (IBS)...

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Bibliographic Details
Main Authors: C. von Muhlenbrock, P. Núñez, K. Herrera, N. Pacheco, R. Quera
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Revista de Gastroenterología de México (English Edition)
Subjects:
Trasplante microbiota fecal
Síndrome de intestino irritable
Colonoscopia
Tratamiento
Microbiota
Online Access:http://www.sciencedirect.com/science/article/pii/S2255534X25000647
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Summary:Recent studies have explored the role of the microbiota in disorders of gut-brain interaction, opening pathways for therapies, such as dietary adjustments, probiotics, and fecal microbiota transplantation (FMT). We present herein a pilot study on 4 patients with severe irritable bowel syndrome (IBS), refractory to conventional treatment, in which FMT through colonoscopy showed improvement in pain, bloating, and stool consistency that was maintained during the 6-month follow-up. To establish the broader clinical application of FMT, more research on its efficacy according to instillation site and patient results is needed. Resumen: En estudios recientes se ha investigado el rol de la microbiota en los trastornos del eje cerebro-intestino, abriendo posibilidades para terapias como ajustes dietéticos, probióticos y el trasplante de microbiota fecal (TMF). Presentamos aquí un estudio piloto de 4 pacientes con síndrome de intestino irritable (SII) severo y refractario a tratamiento convencional, donde el TMF mediante colonoscopia mostró mejoría en el dolor, la distensión y la consistencia de las heces, mantenidas durante 6 meses de seguimiento. Es necesario realizar más investigaciones sobre la eficacia según el sitio de instilación y los resultados en pacientes para establecer su aplicación clínica más amplia.
ISSN:2255-534X

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